{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T14:40:01Z","timestamp":1756305601385,"version":"3.44.0"},"reference-count":25,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2015,11,28]]},"abstract":"<jats:p>Abacavir hypersensitivity is a rare, yet significant adverse reaction that results in a spectrum of physical and laboratory abnormalities, and has been postulated to stem from a variety of aetiological factors. The major histocompatibility complex haplotype human leucocyte antigen (HLA)-B5701 is a significant risk factor in development of hypersensitivity reactions, yet only 55% of HLA-B5701+ individuals develop such reactions, suggesting a multifactorial aetiology. Nevertheless, prospective screening and avoidance of abacavir in these patients has limited adverse events. Within this spectrum of adverse events, abacavir-induced liver toxicity is exceedingly rare and reported events have ranged from mild elevations of aminotransferases to fulminant hepatic failure. We report the case of a 50-year-old Caucasian woman with a history significant for HIV, hepatitis C virus and a HLA-B5701+ status, transferred to our emergency department in a hypotensive state and found to have acute liver failure, acute renal failure and significant rhabdomyolysis following a change of highly active antiretroviral therapy regimen.<\/jats:p>","DOI":"10.1136\/bcr-2015-212566","type":"journal-article","created":{"date-parts":[[2015,12,15]],"date-time":"2015-12-15T07:57:57Z","timestamp":1450166277000},"page":"bcr2015212566","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Abacavir-induced fulminant hepatic failure in a HIV\/HCV co-infected patient"],"prefix":"10.1136","volume":"2015","author":[{"given":"Christopher","family":"Haas","sequence":"first","affiliation":[{"name":"Drexel Medicine, Philadelphia, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Rodriguez","family":"Ziccardi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Einstein Medical Center, Philadelphia, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jody","family":"Borgman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine\/Infectious Disease, Einstein Medical Center, Philadelphia, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2015,12,15]]},"reference":[{"key":"2025082707191542000_2015.dec15_1.bcr2015212566.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(01)80132-6"},{"key":"2025082707191542000_2015.dec15_1.bcr2015212566.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)07873-X"},{"key":"2025082707191542000_2015.dec15_1.bcr2015212566.3","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0307067101"},{"key":"2025082707191542000_2015.dec15_1.bcr2015212566.4","doi-asserted-by":"publisher","DOI":"10.1002\/phar.1278"},{"key":"2025082707191542000_2015.dec15_1.bcr2015212566.5","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199907300-00026"},{"key":"2025082707191542000_2015.dec15_1.bcr2015212566.6","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199905280-00022"},{"key":"2025082707191542000_2015.dec15_1.bcr2015212566.7","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200208160-00022"},{"key":"2025082707191542000_2015.dec15_1.bcr2015212566.8","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199816000-00002"},{"key":"2025082707191542000_2015.dec15_1.bcr2015212566.9","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.3.716-723.2002"},{"key":"2025082707191542000_2015.dec15_1.bcr2015212566.10","doi-asserted-by":"publisher","DOI":"10.1021\/tx200337b"},{"key":"2025082707191542000_2015.dec15_1.bcr2015212566.11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2012.02079.x"},{"key":"2025082707191542000_2015.dec15_1.bcr2015212566.12","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1038\/nature11147","article-title":"Immune self-reactivity triggered by drug-modified HLA-peptide repertoire","volume":"486","author":"Illing","year":"2012","journal-title":"Nature"},{"key":"2025082707191542000_2015.dec15_1.bcr2015212566.13","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1207934109"},{"key":"2025082707191542000_2015.dec15_1.bcr2015212566.14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0117160"},{"key":"2025082707191542000_2015.dec15_1.bcr2015212566.15","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08158-8"},{"key":"2025082707191542000_2015.dec15_1.bcr2015212566.16","doi-asserted-by":"publisher","DOI":"10.1086\/504874"},{"key":"2025082707191542000_2015.dec15_1.bcr2015212566.17","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328273bc07"},{"key":"2025082707191542000_2015.dec15_1.bcr2015212566.18","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0706135"},{"key":"2025082707191542000_2015.dec15_1.bcr2015212566.19","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000139"},{"key":"2025082707191542000_2015.dec15_1.bcr2015212566.20","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32831c8af4"},{"key":"2025082707191542000_2015.dec15_1.bcr2015212566.21","unstructured":"Medicines C.o.S.o. 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