{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T02:28:59Z","timestamp":1789007339526,"version":"build-2803163510"},"reference-count":25,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2016,5,4]]},"abstract":"<jats:p>Gonadal dysgenesis and Mayer-Rokitansky-K\u00fcster-Hauser syndrome (MRKHS) are the most common causes of primary amenorrhoea. Patients with gonadal dysgenesis present with primary amenorrhoea and lack of secondary sexual characteristics, which, in contrast, are present in patients with MRKHS. The coexistence of the 2 syndromes has been reported in only a few studies so far. We describe a case of a 15-year-old girl who presented with short stature and primary amenorrhoea. Investigations revealed hypergonadotropic hypogonadism, and absence of the uterus, and upper two-thirds of the vagina, with presence of the rudimentary lower third of the vagina and non-visualised bilateral ovaries on imaging. Karyotyping obtained by lymphocyte culture GTG banding revealed 45X\/46XX. The patient was diagnosed as having a rare case of gonadal dysgenesis with MRKH. She was started on growth hormone therapy. The association of these syndromes is uncommon, and has further implications on fertility and pregnancy, affecting the quality of life.<\/jats:p>","DOI":"10.1136\/bcr-2015-212634","type":"journal-article","created":{"date-parts":[[2016,5,21]],"date-time":"2016-05-21T17:45:23Z","timestamp":1463852723000},"page":"bcr2015212634","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Unusual association of Turner syndrome and Mayer-Rokitansky-K\u00fcster-Hauser syndrome"],"prefix":"10.1136","volume":"2016","author":[{"given":"Alpana","family":"Meena","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mradul Kumar","family":"Daga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashmi","family":"Dixit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2016,5,20]]},"reference":[{"key":"2025042703265715000_2016.may20_1.bcr2015212634.1","doi-asserted-by":"crossref","first-page":"S387","DOI":"10.4103\/2230-8210.104103","article-title":"Contemporary issues in primary amenorrhea: an experience from a tertiary care center","volume":"16","author":"Bhuyan","year":"2012","journal-title":"Indian J Endocrinol Metab"},{"key":"2025042703265715000_2016.may20_1.bcr2015212634.2","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1002\/ajmg.a.32645","article-title":"Primary hypogonadism, partial alopecia, and Mullerian hypoplasia: report of a third family and review","volume":"149A","author":"Tatar","year":"2009","journal-title":"Am J Med Genet A"},{"key":"2025042703265715000_2016.may20_1.bcr2015212634.3","doi-asserted-by":"crossref","first-page":"847370","DOI":"10.1155\/2010\/847370","article-title":"Gonadal dysgenesis 46, XX Associated with Mayer-Rokitansky-Kuster-Hauser Syndrome: one case report","volume":"2010","author":"Bousfiha","year":"2010","journal-title":"Obstet Gynecol Int"},{"key":"2025042703265715000_2016.may20_1.bcr2015212634.4","doi-asserted-by":"crossref","first-page":"246","DOI":"10.18203\/2349-3291.ijcp20150537","article-title":"Gonadal dysgenesis and the Mayer-Rokitansky-Kuster- Hauser syndrome in a girl with a 46, XX karyotype: a case report","volume":"2","author":"Bhandari","year":"2015","journal-title":"Int J Contemp Pediatr"},{"key":"2025042703265715000_2016.may20_1.bcr2015212634.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpag.2015.10.019"},{"key":"2025042703265715000_2016.may20_1.bcr2015212634.6","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8210.111663"},{"key":"2025042703265715000_2016.may20_1.bcr2015212634.7","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8210.119605"},{"key":"2025042703265715000_2016.may20_1.bcr2015212634.8","first-page":"571","article-title":"Primary hypergonadotrophic hypogonadism, alopecia totalis, and m\u00fcllerian hypoplasia: a clinical study","volume":"59","author":"Zaman","year":"2009","journal-title":"J Pak Med Assoc"},{"key":"2025042703265715000_2016.may20_1.bcr2015212634.9","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/ajmg.a.32048","article-title":"The Mayer-Rokitansky-Kuster-Hauser and gonadal dysgenesis anomaly in a girl with 45, X\/46, X, del (X) (p11.21)","volume":"146A","author":"G\u00fcven","year":"2008","journal-title":"Am J Med Genet A"},{"key":"2025042703265715000_2016.may20_1.bcr2015212634.10","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-006-0238-z"},{"key":"2025042703265715000_2016.may20_1.bcr2015212634.11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2007.00404.x"},{"key":"2025042703265715000_2016.may20_1.bcr2015212634.12","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4266(04)95953-7"},{"key":"2025042703265715000_2016.may20_1.bcr2015212634.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2003.07.029"},{"key":"2025042703265715000_2016.may20_1.bcr2015212634.14","first-page":"902","article-title":"Mayer-Rokitansky-K\u00fcster-Hauser syndrome associated with unilateral gonadal agenesis. 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