{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T08:10:19Z","timestamp":1756282219583,"version":"3.44.0"},"reference-count":10,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2016,1,16]]},"abstract":"<jats:p>Acute leukaemias occur as the result of clonal expansion subsequent to transformation and arrest at a normal differentiation stage of haematopoietic precursors, which commit to a single lineage, such as myeloid or B-lymphoid or T-lymphoid cells. Biphenotypic acute leukaemia (BAL) constitutes a biologically different group of leukaemia arising from a precursor stem cell and co-expressing more than one lineage specific marker. The present report describes a child with unusual co-occurrence of biphenotypic (B-precursor cell and Myeloid) acute leukaemia, haemoglobin E trait and glucose 6-phosphate dehydrogenase (G6-PD) deficiency. To the best of our knowledge, this constellation of haematological conditions in a single child has never been described before.<\/jats:p>","DOI":"10.1136\/bcr-2015-212714","type":"journal-article","created":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T06:27:32Z","timestamp":1454308052000},"page":"bcr2015212714","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Co-occurrence of biphenotypic acute leukaemia, glucose 6-phosphate dehydrogenase deficiency and haemoglobin E trait in a single child"],"prefix":"10.1136","volume":"2016","author":[{"given":"Debkrishna","family":"Mallick","sequence":"first","affiliation":[{"name":"Department of Paediatric Medicine, HEEM, Boston, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajoo","family":"Thapa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Golisano Children's Hospital, Syracuse, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biswajit","family":"Biswas","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Institute of Child Health, Kolkata, West Bengal, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2016,2,1]]},"reference":[{"key":"2025082700372088000_2016.jan31_1.bcr2015212714.1","unstructured":"Tubergen DG , Bleyer A . 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