{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T01:40:10Z","timestamp":1783388410919,"version":"3.54.6"},"reference-count":7,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2015,10,26]]},"abstract":"<jats:p>A 47-year-old man presented with persistent diarrhoea and hypokalaemia. CT revealed 4 pancreatic tumours that appeared to be VIPomas, because the patient had an elevated plasma vasoactive intestinal polypeptide level. MRI showed a low-intensity area in the pituitary suggestive of a pituitary tumour, and a parathyroid tumour was detected by ultrasonography and 99Tc-MIBI scintigraphy. Given these results, the patient was diagnosed with multiple endocrine neoplasia type 1 (MEN1) and scheduled for surgery. MEN1 is an autosomal dominant disorder associated with <jats:italic>MEN1<\/jats:italic> mutations. Genetic testing indicated that the patient had a <jats:italic>MEN1<\/jats:italic> gene mutation; his 2 sons had the same mutations. Most MEN1 tumours are benign, but some pancreatic and thymic tumours could become malignant. Without treatment, such tumours would result in earlier mortality. Despite its rarity, we should perform genetic testing for family members of patients with MEN1 to identify mutation carriers and improve the patients\u2019 prognosis.<\/jats:p>","DOI":"10.1136\/bcr-2015-213016","type":"journal-article","created":{"date-parts":[[2015,11,12]],"date-time":"2015-11-12T10:17:32Z","timestamp":1447323452000},"page":"bcr2015213016","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["VIPoma with multiple endocrine neoplasia type 1 identified as an atypical gene mutation"],"prefix":"10.1136","volume":"2015","author":[{"given":"Atsushi","family":"Fujiya","sequence":"first","affiliation":[{"name":"Department of Diabetology and Nephrology, Ogaki Municipal Hospital, Ogaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Diabetology and Nephrology, Ogaki Municipal Hospital, Ogaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiga","family":"Shibata","sequence":"additional","affiliation":[{"name":"Department of Diabetology and Nephrology, Ogaki Municipal Hospital, Ogaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Sobajima","sequence":"additional","affiliation":[{"name":"Department of Diabetology and Nephrology, Ogaki Municipal Hospital, Ogaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2015,11,12]]},"reference":[{"key":"2025082803280584000_2015.nov12_1.bcr2015213016.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(57)92051-2"},{"key":"2025082803280584000_2015.nov12_1.bcr2015213016.2","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-007-0177-0"},{"key":"2025082803280584000_2015.nov12_1.bcr2015213016.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61217-9"},{"key":"2025082803280584000_2015.nov12_1.bcr2015213016.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2015.04.005"},{"key":"2025082803280584000_2015.nov12_1.bcr2015213016.5","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.44.841"},{"key":"2025082803280584000_2015.nov12_1.bcr2015213016.6","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20605"},{"key":"2025082803280584000_2015.nov12_1.bcr2015213016.7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2011.04227.x"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2015-213016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T10:28:13Z","timestamp":1756376893000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2015-213016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,12]]},"references-count":7,"alternative-id":["10.1136\/bcr-2015-213016"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2015-213016","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,12]]}}}