{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T05:40:23Z","timestamp":1756359623200,"version":"3.44.0"},"reference-count":28,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2015,11,30]]},"abstract":"<jats:p>\n                  <jats:italic>Clostridium perfringens<\/jats:italic> bacteraemia is a potentially fatal condition, and its early identification is paramount to maximise chances of survival. Prompt recognition of intravascular haemolysis, a known complication of <jats:italic>C. perfringens<\/jats:italic> bacteraemia, can help guide clinical decision-making before microbiology data becomes available. We present a novel finding of severe hypertension in a fatal case of <jats:italic>Clostridial<\/jats:italic> bacteraemia with massive haemolysis. A 58-year-old man with no known medical history presented to the emergency department with malaise, fever and hypertension. He developed abdominal pain and a hepatic abscess was identified on CT imaging. Within 4\u2005h of presentation, he developed massive intravascular haemolysis, extreme hypertension, pulmonary oedema and respiratory failure. He died less than 8\u2005h after presentation. His blood cultures subsequently grew <jats:italic>C. perfringens<\/jats:italic>. This case underscores the importance of early recognition of intravascular haemolysis complicating <jats:italic>C. perfringens<\/jats:italic> bacteraemia, and discusses the rare complication of hypertensive emergency in this setting.<\/jats:p>","DOI":"10.1136\/bcr-2015-213253","type":"journal-article","created":{"date-parts":[[2016,1,28]],"date-time":"2016-01-28T11:30:21Z","timestamp":1453980621000},"page":"bcr2015213253","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Hepatic abscess-associated <i>Clostridial<\/i> bacteraemia presenting with intravascular haemolysis and severe hypertension"],"prefix":"10.1136","volume":"2016","author":[{"given":"Andrew George","family":"Lim","sequence":"first","affiliation":[{"name":"Division of Emergency Medicine, Department of Medicine, University of Washington, Seattle, Washington, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina 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