{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T06:59:39Z","timestamp":1785394779903,"version":"3.55.0"},"reference-count":14,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2016,1,27]]},"abstract":"<jats:p>Kearns-Sayre syndrome (KSS) is a mitochondrial myopathy resulting from mitochondrial DNA deletion. This syndrome primarily involves the central nervous system, eyes, skeletal muscles and the heart. The most well-known cardiac complications involve the conduction system; however, there have been case reports describing cardiomyopathy. We describe a case of a child with KSS who presented with decompensated cardiac failure from dilated cardiomyopathy representing cardiomyocyte involvement of KSS. Our patient had a rapidly progressing course, despite maximal medical management, requiring emergent institution of extracorporeal membrane oxygenation and transition to a ventricular assist device. To the best of our knowledge, this is the youngest patient in the literature to have dilated cardiomyopathy in KSS.<\/jats:p>","DOI":"10.1136\/bcr-2015-213813","type":"journal-article","created":{"date-parts":[[2016,2,16]],"date-time":"2016-02-16T07:50:27Z","timestamp":1455609027000},"page":"bcr2015213813","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Dilated cardiomyopathy with cardiogenic shock in a child with Kearns-Sayre syndrome"],"prefix":"10.1136","volume":"2016","author":[{"given":"Swati","family":"Sehgal","sequence":"first","affiliation":[{"name":"Department of Pediatric Cardiology, Children's Hospital of Michigan, Detroit Medical Center, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swati","family":"Choudhry","sequence":"additional","affiliation":[{"name":"Children's Hospital of Michigan, Detroit Medical Center and Washington University School of Medicine, St Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larisa","family":"Debelenko","sequence":"additional","affiliation":[{"name":"Department of Pathology, Children's Hospital of Michigan, Detroit Medical Center, Detroit, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"L'Ecuyer","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Children's Hospital of Michigan, Detroit Medical Center, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2016,2,16]]},"reference":[{"key":"2025082701560475000_2016.feb16_1.bcr2015213813.1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1958.00940080296016"},{"key":"2025082701560475000_2016.feb16_1.bcr2015213813.2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.91.4.955"},{"key":"2025082701560475000_2016.feb16_1.bcr2015213813.3","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410010104"},{"key":"2025082701560475000_2016.feb16_1.bcr2015213813.4","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.63.1.214"},{"key":"2025082701560475000_2016.feb16_1.bcr2015213813.5","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.1998.1057"},{"key":"2025082701560475000_2016.feb16_1.bcr2015213813.6","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1093\/oxfordjournals.eurheartj.a059477","article-title":"Indications for pacemaker implantation in the Kearns-Sayre syndrome","volume":"10","author":"Polak","year":"1989","journal-title":"Eur Heart J"},{"key":"2025082701560475000_2016.feb16_1.bcr2015213813.7","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.1540-8159.2007.00590.x","article-title":"Torsades de pointes in a patient with Kearns-Sayre syndrome: a fortunate finding","volume":"30","author":"Subbiah","year":"2007","journal-title":"Pacing Clin Electrophysiol"},{"issue":"(4 part II)","key":"2025082701560475000_2016.feb16_1.bcr2015213813.8","first-page":"576","article-title":"Incidence of conduction system disease and need for permanent pacemaker in patients with Kearns Sayre syndrome. (abstract 149)","volume":"24","author":"Hayes","year":"2001","journal-title":"PACE"},{"key":"2025082701560475000_2016.feb16_1.bcr2015213813.9","first-page":"65","article-title":"Progression of conduction system disease in a paced patient with Kearns-Sayre syndrome","volume":"32","author":"Yesil","year":"2007","journal-title":"Clin Cardiol"},{"key":"2025082701560475000_2016.feb16_1.bcr2015213813.10","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfp186"},{"key":"2025082701560475000_2016.feb16_1.bcr2015213813.11","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.59.4.486"},{"key":"2025082701560475000_2016.feb16_1.bcr2015213813.12","doi-asserted-by":"publisher","DOI":"10.1016\/0960-8966(93)90116-2"},{"key":"2025082701560475000_2016.feb16_1.bcr2015213813.13","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2007.11.024"},{"key":"2025082701560475000_2016.feb16_1.bcr2015213813.14","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-668X(02)00694-2"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2015-213813","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T08:56:13Z","timestamp":1756284973000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2015-213813"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,16]]},"references-count":14,"alternative-id":["10.1136\/bcr-2015-213813"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2015-213813","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,16]]}}}