{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T08:04:30Z","timestamp":1792137870943,"version":"4.4.0"},"reference-count":14,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2016,2,10]]},"abstract":"<jats:p>A 25-year-old woman presented with unilateral red eye and visual blur, and was found to have panuveitis with an inflammatory white mass at the macula, initially presumed to be<jats:italic>Toxoplasma<\/jats:italic>retinitis. After failure to respond, she underwent vitrectomy, which produced<jats:italic>Candida albicans<\/jats:italic>. Despite intraocular and systemic antifungal treatment, she lost all vision in that eye. Two years later, she developed unilateral hip osteomyelitis leading to total hip replacement and also revealing<jats:italic>Candida<\/jats:italic>infection. By clinical exome sequencing, she was then found to have caspase recruitment domain 9 (CARD9) deficiency, an autosomal recessive disorder that causes a specific susceptibility to candidal infections. She remains otherwise well but on lifelong fluconazole prophylaxis.<\/jats:p>","DOI":"10.1136\/bcr-2015-214117","type":"journal-article","created":{"date-parts":[[2016,3,3]],"date-time":"2016-03-03T15:58:59Z","timestamp":1457020739000},"page":"bcr2015214117","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":31,"title":["Endogenous<i>Candida<\/i>endophthalmitis and osteomyelitis associated with CARD9 deficiency"],"prefix":"10.1136","volume":"2016","author":[{"given":"Nicholas","family":"Jones","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomaz","family":"Garcez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Newman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Denning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2016,3,3]]},"reference":[{"key":"2025042702515122000_2016.mar03_1.bcr2015214117.1","doi-asserted-by":"publisher","DOI":"10.1177\/014107689208501204"},{"key":"2025042702515122000_2016.mar03_1.bcr2015214117.2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04926"},{"key":"2025042702515122000_2016.mar03_1.bcr2015214117.3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0810719"},{"key":"2025042702515122000_2016.mar03_1.bcr2015214117.4","doi-asserted-by":"publisher","DOI":"10.1002\/emmm.201201678"},{"key":"2025042702515122000_2016.mar03_1.bcr2015214117.5","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20082818"},{"key":"2025042702515122000_2016.mar03_1.bcr2015214117.6","doi-asserted-by":"publisher","DOI":"10.1038\/ni1460"},{"key":"2025042702515122000_2016.mar03_1.bcr2015214117.7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1208487"},{"key":"2025042702515122000_2016.mar03_1.bcr2015214117.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.12.1930"},{"key":"2025042702515122000_2016.mar03_1.bcr2015214117.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2009.08.020"},{"key":"2025042702515122000_2016.mar03_1.bcr2015214117.10","doi-asserted-by":"crossref","first-page":"118","DOI":"10.3109\/09273948.2013.855799","article-title":"The Manchester Uveitis Clinic: the first 3000 patients\u2014epidemiology and casemix","volume":"23","author":"Jones","year":"2013","journal-title":"J Ocular Immunol Inflammation"},{"key":"2025042702515122000_2016.mar03_1.bcr2015214117.11","doi-asserted-by":"publisher","DOI":"10.1186\/1869-5760-3-60"},{"key":"2025042702515122000_2016.mar03_1.bcr2015214117.12","doi-asserted-by":"publisher","DOI":"10.1038\/eye.1998.75"},{"key":"2025042702515122000_2016.mar03_1.bcr2015214117.13","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.120.4.518"},{"key":"2025042702515122000_2016.mar03_1.bcr2015214117.14","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e31822d3a34"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2015-214117","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T09:52:00Z","timestamp":1745747520000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2015-214117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,3]]},"references-count":14,"alternative-id":["10.1136\/bcr-2015-214117"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2015-214117","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,3]]}}}