{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:08:49Z","timestamp":1783037329464,"version":"3.54.6"},"reference-count":11,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2016,6,6]]},"abstract":"<jats:p>Cytomegalovirus (CMV) infection is the most common viral opportunistic infection in immunocompromised patients and is a rare cause of bowel perforation. It invariably requires surgical intervention and is often fatal. We report a 50-year-old Caucasian man with AIDS, presented 3\u2005weeks after developing abdominal pain and distension. He was treated for CMV retinitis in the past. His adherence to antiretroviral therapy was poor. Examination revealed a recurrence of active CMV retinitis. His abdomen was tender and distended. The plain X-ray of the abdomen revealed a double wall sign (Rigler's sign), indicating pneumoperitoneum due to the bowel perforation. The upper endoscopy was normal. His CD4 count was 30\u2005cells\/mm<jats:sup>3<\/jats:sup>. He was treated with cidofovir infusion. He made a full recovery, without requiring any form of surgery. However, he died of adult respiratory distress syndrome 14\u2005months later, due to iatrogenic acute pancreatitis.<\/jats:p>","DOI":"10.1136\/bcr-2015-214196","type":"journal-article","created":{"date-parts":[[2016,7,20]],"date-time":"2016-07-20T14:53:25Z","timestamp":1469026405000},"page":"bcr2015214196","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Perforation of the bowel due to cytomegalovirus infection in a man with AIDS: surgery is not always necessary!"],"prefix":"10.1136","volume":"2016","author":[{"given":"Katie Tharshana","family":"Yoganathan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew Roger","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathir G","family":"Yoganathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2016,7,20]]},"reference":[{"key":"2025042703463046000_2016.jul20_1.bcr2015214196.1","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-200006000-00016"},{"key":"2025042703463046000_2016.jul20_1.bcr2015214196.2","doi-asserted-by":"publisher","DOI":"10.1136\/emj.2006.039651"},{"key":"2025042703463046000_2016.jul20_1.bcr2015214196.3","doi-asserted-by":"publisher","DOI":"10.1258\/ijsa.2008.008341"},{"key":"2025042703463046000_2016.jul20_1.bcr2015214196.4","doi-asserted-by":"crossref","first-page":"237","DOI":"10.2147\/OPTH.S2449","article-title":"Ischaemic maculopathy in zidovudine-induced anemia in an HIV-positive man","volume":"2","author":"Yoganathan","year":"2008","journal-title":"Clin Ophthalmol"},{"key":"2025042703463046000_2016.jul20_1.bcr2015214196.5","first-page":"473","article-title":"Retinal and gastrointestinal disease due to cytomegalovirus in patients with the acquired immune deficiency syndrome: prevalence, natural history, and response to ganciclovir therapy","volume":"67","author":"Jacobson","year":"1988","journal-title":"Q J Med"},{"key":"2025042703463046000_2016.jul20_1.bcr2015214196.6","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1992.01420010120019"},{"key":"2025042703463046000_2016.jul20_1.bcr2015214196.7","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(93)90665-Y"},{"key":"2025042703463046000_2016.jul20_1.bcr2015214196.8","doi-asserted-by":"publisher","DOI":"10.1007\/BF02139220"},{"key":"2025042703463046000_2016.jul20_1.bcr2015214196.9","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1987.01400140052006"},{"key":"2025042703463046000_2016.jul20_1.bcr2015214196.10","first-page":"794","article-title":"Toxic megacolon in cytomegalovirus colitis","volume":"84","author":"Orloff","year":"1989","journal-title":"Am J Gastroenterol"},{"key":"2025042703463046000_2016.jul20_1.bcr2015214196.11","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-8389(03)00100-3"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2015-214196","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T10:46:38Z","timestamp":1745750798000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2015-214196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,20]]},"references-count":11,"alternative-id":["10.1136\/bcr-2015-214196"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2015-214196","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,20]]}}}