{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T12:50:19Z","timestamp":1784811019828,"version":"3.55.0"},"reference-count":8,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2016,2,4]]},"abstract":"<jats:p>A 51-year-old man presented with intermittent fever, mild cough and loss of appetite of 1-month duration. His sputum smear was positive for acid-fast bacilli and his chest radiograph revealed apical infiltrations. The patient was treated with antitubercular therapy (ATT), recovered and was well for 1\u2005month, after which he suddenly developed focal seizures. MRI of the brain with gadolinium enhancement showed high intensity nodular foci in the frontal, parietal and occipital regions. The patient was diagnosed as a case of paradoxical reaction to ATT, and was successfully managed with continued ATT and adjunctive steroid therapy.<\/jats:p>","DOI":"10.1136\/bcr-2015-214285","type":"journal-article","created":{"date-parts":[[2016,2,17]],"date-time":"2016-02-17T07:32:47Z","timestamp":1455694367000},"page":"bcr2015214285","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Paradoxical reaction to antitubercular treatment in a case of pulmonary tuberculosis"],"prefix":"10.1136","volume":"2016","author":[{"given":"Buddhi","family":"Paudyal","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Patan Academy of Health Sciences, Kathmandu, Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kshitiz","family":"Paudel","sequence":"additional","affiliation":[{"name":"Amppipal Hospital, Gorkha, Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mila","family":"Shakya","sequence":"additional","affiliation":[{"name":"Oxford University Clinical Research Unit, Patan Hospital, Kathmandu, Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Buddha","family":"Basnyat","sequence":"additional","affiliation":[{"name":"Oxford University Clinical Research Unit, Patan Hospital, Kathmandu, Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2016,2,17]]},"reference":[{"key":"2025082703244515000_2016.feb17_1.bcr2015214285.1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-002-0821-2"},{"key":"2025082703244515000_2016.feb17_1.bcr2015214285.2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(05)70299-1"},{"key":"2025082703244515000_2016.feb17_1.bcr2015214285.3","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-198609000-00028"},{"key":"2025082703244515000_2016.feb17_1.bcr2015214285.4","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/19.6.1092"},{"key":"2025082703244515000_2016.feb17_1.bcr2015214285.5","doi-asserted-by":"publisher","DOI":"10.4103\/0976-3147.102622"},{"key":"2025082703244515000_2016.feb17_1.bcr2015214285.6","doi-asserted-by":"crossref","unstructured":"Ira S . Paradoxical appearance of intracranial tuberculoma in a child with tuberculous meningitis. J Trop Pediatr 51:191\u20133. doi:10.1093\/tropej\/fmi019","DOI":"10.1093\/tropej\/fmi019"},{"key":"2025082703244515000_2016.feb17_1.bcr2015214285.7","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)90478-1"},{"key":"2025082703244515000_2016.feb17_1.bcr2015214285.8","doi-asserted-by":"publisher","DOI":"10.2149\/tmh.2012-09"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2015-214285","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T10:24:52Z","timestamp":1756290292000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2015-214285"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,17]]},"references-count":8,"alternative-id":["10.1136\/bcr-2015-214285"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2015-214285","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,17]]}}}