{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T07:40:21Z","timestamp":1756366821500,"version":"3.44.0"},"reference-count":17,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2016,2,27]]},"abstract":"<jats:p>Glioblastoma multiforme (GBM) is a high-grade primary brain tumour with a notably poor prognosis. Research demonstrates a median survival of just over 1\u2005year following aggressive treatment. Long-term survival is notably rare. Cranial radiotherapy and postexcisional prophylactic treatment is associated with the development of second, histologically distinct tumours in rare cases. Radiation-induced intracranial schwannomas are uncommon, with only a small number of cranial nerve schwannoma cases reported in recent decades. To our knowledge, this is the first reported case of a radiation-induced benign trigeminal schwannoma occurring following long-term survival from glioblastoma. Here we present (1) a rare case of 14-year survival following treatment of a right parietal glioblastoma and the development of a radiation-induced benign trigeminal schwannoma in a 35-year-old man, and (2) a review of radiation-induced schwannoma cases reported in the existing literature.<\/jats:p>","DOI":"10.1136\/bcr-2016-214438","type":"journal-article","created":{"date-parts":[[2016,3,11]],"date-time":"2016-03-11T09:47:39Z","timestamp":1457689659000},"page":"bcr2016214438","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Rare case of radiation-induced trigeminal schwannoma occurring in a long-term glioblastoma multiforme survivor"],"prefix":"10.1136","volume":"2016","author":[{"given":"Mina","family":"Al Shalchi","sequence":"first","affiliation":[{"name":"School of Medicine, Keele University, Staffordshire, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaila","family":"Hussain","sequence":"additional","affiliation":[{"name":"School of Medicine, Keele University, Staffordshire, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selvaraj","family":"Giridharan","sequence":"additional","affiliation":[{"name":"Cancer Centre, University Hospital of North Midlands, Stoke-on-Trent, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erminia","family":"Albanese","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Hospital of North Midlands, Stoke-on-Trent, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2016,3,11]]},"reference":[{"key":"2025082800010734000_2016.mar11_1.bcr2016214438.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnci.2012.11.001"},{"key":"2025082800010734000_2016.mar11_1.bcr2016214438.2","doi-asserted-by":"crossref","first-page":"929","DOI":"10.3892\/ijo.2013.1770","article-title":"Extent of resection and radiotherapy in GBM: a 1973 to 2007 surveillance, epidemiology and end results analysis of 21,783 patients","volume":"42","author":"Zinn","year":"2013","journal-title":"Int J Oncol"},{"key":"2025082800010734000_2016.mar11_1.bcr2016214438.3","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(194805)1:1<3::AID-CNCR2820010103>3.0.CO;2-7"},{"key":"2025082800010734000_2016.mar11_1.bcr2016214438.4","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm204"},{"key":"2025082800010734000_2016.mar11_1.bcr2016214438.5","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2001.95.2.0190"},{"key":"2025082800010734000_2016.mar11_1.bcr2016214438.6","doi-asserted-by":"publisher","DOI":"10.3171\/2011.2.JNS10998"},{"key":"2025082800010734000_2016.mar11_1.bcr2016214438.7","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-008-0631-7"},{"key":"2025082800010734000_2016.mar11_1.bcr2016214438.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2014.12.009"},{"key":"2025082800010734000_2016.mar11_1.bcr2016214438.9","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1111\/neup.12022","article-title":"A case of more than 20 years survival with glioblastoma, and development of cavernous angioma as a delayed complication of radiotherapy","volume":"33","author":"Fukushima","year":"2013","journal-title":"Neuropathology"},{"key":"2025082800010734000_2016.mar11_1.bcr2016214438.10","first-page":"TD05","article-title":"An early and rare second malignancy in a treated glioblastoma multiforme: is it radiation or temozolomide?","volume":"9","author":"Goyal","year":"2015","journal-title":"J Clin Diagn Res"},{"key":"2025082800010734000_2016.mar11_1.bcr2016214438.11","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000053365.05795.03"},{"key":"2025082800010734000_2016.mar11_1.bcr2016214438.12","first-page":"505","article-title":"Malignant schwannoma of the trigeminal nerve","volume":"22","author":"Stone","year":"2001","journal-title":"AJNR Am J Neuroradiol"},{"key":"2025082800010734000_2016.mar11_1.bcr2016214438.13","first-page":"113","article-title":"Radiation-induced schwannomas of the nervous system. Report of five cases and review of the literature","volume":"47","author":"Salvati","year":"2003","journal-title":"J Neurosurg Sci"},{"key":"2025082800010734000_2016.mar11_1.bcr2016214438.14","doi-asserted-by":"publisher","DOI":"10.1215\/15228517-2007-047"},{"key":"2025082800010734000_2016.mar11_1.bcr2016214438.15","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000064809.59806.E8"},{"key":"2025082800010734000_2016.mar11_1.bcr2016214438.16","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-198906000-00026"},{"key":"2025082800010734000_2016.mar11_1.bcr2016214438.17","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1997.86.2.0286"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2016-214438","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T07:01:17Z","timestamp":1756364477000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2016-214438"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,11]]},"references-count":17,"alternative-id":["10.1136\/bcr-2016-214438"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2016-214438","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2016,3,11]]}}}