{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:43:21Z","timestamp":1790822601968,"version":"4.1.0"},"reference-count":8,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2016,4,5]]},"abstract":"<jats:p>Thyroid storm is a rare and life-threatening state of thyroid hormone excess. Rapid recognition of thyroid storm is key to decreasing the morbidity and mortality of this condition. Clinical manifestations of thyroid storm include unexplained weight loss, hyperactivity and irritability. The most common causes of thyrotoxicosis are Graves' disease, toxic multinodular goitre and toxic adenoma. We present a rare case of thyroid storm induced by dual nivolumab and ipilimumab immunotherapy in a patient receiving treatment for advanced melanoma. In this case, our patient was admitted for thyroid storm 1\u2005month after initiating treatment with nivolumab and ipilimumab immunotherapy. The patient was treated with \u03b2-blockers, antithyroid medications and systemic steroids resulting in an improvement in thyroid function testing and symptoms.<\/jats:p>","DOI":"10.1136\/bcr-2016-214603","type":"journal-article","created":{"date-parts":[[2016,4,18]],"date-time":"2016-04-18T10:22:46Z","timestamp":1460974966000},"page":"bcr2016214603","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":66,"title":["A rare case of thyroid storm"],"prefix":"10.1136","volume":"2016","author":[{"given":"Brock","family":"McMillen","sequence":"first","affiliation":[{"name":"Department of Family Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manvinder Shelley","family":"Dhillon","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Yong-Yow","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2016,4,18]]},"reference":[{"key":"2025082802264179000_2016.apr18_1.bcr2016214603.1","doi-asserted-by":"publisher","DOI":"10.4158\/EP.17.3.456"},{"key":"2025082802264179000_2016.apr18_1.bcr2016214603.2","unstructured":"Jameson JL , Mandel SJ , Weetman AP . Disorders of the thyroid gland. In: Harrison's principles of internal medicine. 19th edn. New York, NY: McGraw-Hill, 2015. Retrieved 4 January 2016. http:\/\/accessmedicine.mhmedical.com.proxy.medlib.uits.edu\/content.aspx?bookid=1130&Sectionid=7951787"},{"key":"2025082802264179000_2016.apr18_1.bcr2016214603.3","unstructured":"Kim KB , Davies MA , Rapini RP , et al . The MD Anderson manual of medical oncology. New York, NY: McGraw-Hill, 2011. Retrieved 24 August 2015. http:\/\/accessmedicine.mhmedical.com.proxy.medlib.uits.iu.edu\/content.aspx?sectionid=39902069&bookid=379&jumpsectionID=39908292&Resultclick=2"},{"key":"2025082802264179000_2016.apr18_1.bcr2016214603.4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1302369"},{"key":"2025082802264179000_2016.apr18_1.bcr2016214603.5","unstructured":"Yervoy\u00ae (Ipilimumab) [Internet] 2011 [updated Oct 2015; cited Mar 2016]. http:\/\/packageinserts.bms.com\/pi\/pi_yervoy.pdf"},{"key":"2025082802264179000_2016.apr18_1.bcr2016214603.6","unstructured":"OPDIVO\u00ae (Nivoloumab) [Internet] 2014 [updated Jan 2016; cited Mar 2016]. http:\/\/packageinserts.bms.com\/pi\/pi_opdivo.pdf"},{"key":"2025082802264179000_2016.apr18_1.bcr2016214603.7","unstructured":"YERVOY (ipilimumab) US Prescribing Information: Risk Evaluation and Mitigation Strategy (REMS). 2011 (updated Feb 2012; cited Mar 2016). http:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/rems\/Yervoy_2012-02-16_Full.pdf"},{"key":"2025082802264179000_2016.apr18_1.bcr2016214603.8","doi-asserted-by":"crossref","unstructured":"Yu C , Chopra IJ , Ha E . 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