{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T17:59:47Z","timestamp":1768413587408,"version":"3.49.0"},"reference-count":11,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2016,2,21]]},"abstract":"<jats:p>Drugs, toxins, and infections are known to cause acute eosinophilic pneumonia. Daptomycin and minocycline are the commonly reported antibiotics associated with acute eosinophilic pneumonia. In this study, we present a case of imipenem\/cilastatin-induced acute eosinophilic pneumonia. The patient presented with fever, acute hypoxic respiratory distress, and diffuse ground-glass opacities on the chest CT a day after the initiation of imipenem\/cilastatin. Patient also developed peripheral eosinophilia. A reinstitution of imipenem\/cilastatin resulted in recurrence of the signs and symptoms. A bronchoscopy with bronchoalveolar lavage showed 780 nucleated cells\/mm<jats:sup>3<\/jats:sup> with 15% eosinophil. The patient's clinical condition improved significantly after the discontinuation of imipenem\/cilastatin therapy and the treatment with corticosteroid.<\/jats:p>","DOI":"10.1136\/bcr-2016-214804","type":"journal-article","created":{"date-parts":[[2016,3,4]],"date-time":"2016-03-04T06:57:35Z","timestamp":1457074655000},"page":"bcr2016214804","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Imipenem\/cilastatin-induced acute eosinophilic pneumonia"],"prefix":"10.1136","volume":"2016","author":[{"given":"Kap Sum","family":"Foong","sequence":"first","affiliation":[{"name":"Department of Medicine, Crozer Chester Medical Center, Upland, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiology, Washington University in Saint Louis, Saint Louis, Missouri, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marijeta","family":"Pekez","sequence":"additional","affiliation":[{"name":"Department of Radiology, Washington University in Saint Louis, Saint Louis, Missouri, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Bin","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Crozer-Chester Medical Center, Upland, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2016,3,4]]},"reference":[{"key":"2025082623564931000_2016.mar04_1.bcr2016214804.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198908313210903"},{"key":"2025082623564931000_2016.mar04_1.bcr2016214804.2","unstructured":"The Drug-Induced Respiratory Disease Website; Department of Pulmonary Medicine and Intensive Care University Hospital Dijon France. 2012. http:\/\/www.pneumotox.com (accessed 10 Sep 2015)."},{"key":"2025082623564931000_2016.mar04_1.bcr2016214804.3","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-939522"},{"key":"2025082623564931000_2016.mar04_1.bcr2016214804.4","doi-asserted-by":"publisher","DOI":"10.1086\/652656"},{"key":"2025082623564931000_2016.mar04_1.bcr2016214804.5","doi-asserted-by":"publisher","DOI":"10.3109\/00365548.2013.805427"},{"key":"2025082623564931000_2016.mar04_1.bcr2016214804.6","first-page":"110","article-title":"Minocycline-induced acute eosinophilic pneumonia: a case report and review of the literature","volume":"15","author":"Hung","year":"2015","journal-title":"Respir Med Case Rep"},{"key":"2025082623564931000_2016.mar04_1.bcr2016214804.7","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-939517"},{"key":"2025082623564931000_2016.mar04_1.bcr2016214804.8","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-5231(03)00141-2"},{"key":"2025082623564931000_2016.mar04_1.bcr2016214804.9","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.03.00085903"},{"key":"2025082623564931000_2016.mar04_1.bcr2016214804.10","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2112056"},{"key":"2025082623564931000_2016.mar04_1.bcr2016214804.11","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199611000-00004"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2016-214804","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T06:57:01Z","timestamp":1756277821000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2016-214804"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,4]]},"references-count":11,"alternative-id":["10.1136\/bcr-2016-214804"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2016-214804","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,4]]}}}