{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T21:14:28Z","timestamp":1776978868459,"version":"3.51.4"},"reference-count":14,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2016,3,24]]},"abstract":"<jats:p>Primary malignant mixed M\u00fcllerian tumour (MMMT) of the vagina is a rare entity. We report a case of a 62-year-old woman who presented with a fixed and hard anterior vaginal wall mass with contact bleeding. She proceeded to have an anterior infralevator pelvic exenteration with urethrectomy and anterior vaginectomy, creation of an ileal conduit and bilateral lymph node dissection. Histopathological examination and immunohistochemistry confirmed the diagnosis of primary MMMT of the vagina. The patient was stage IVA at diagnosis. Despite chemotherapy and radiotherapy, she had progressive disease and eventually passed away at the age of 65\u2005years.<\/jats:p>","DOI":"10.1136\/bcr-2016-214856","type":"journal-article","created":{"date-parts":[[2016,4,25]],"date-time":"2016-04-25T12:33:32Z","timestamp":1461587612000},"page":"bcr2016214856","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Primary malignant mixed M\u00fcllerian tumour (MMMT) of the vagina and review of the literature"],"prefix":"10.1136","volume":"2016","author":[{"given":"Geetha","family":"Visvalingam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wai Kheong Ryan","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chin Fong","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong Kuei","family":"Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2016,4,25]]},"reference":[{"key":"2025042703162427000_2016.apr25_1.bcr2016214856.1","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-197510000-00014"},{"key":"2025042703162427000_2016.apr25_1.bcr2016214856.2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(67)90451-6"},{"key":"2025042703162427000_2016.apr25_1.bcr2016214856.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2007.03.008"},{"key":"2025042703162427000_2016.apr25_1.bcr2016214856.4","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1007\/s00404-003-0582-x","article-title":"Primary malignant mixed M\u00fcllerian tumor of the vagina immunohistochemically confirmed","volume":"271","author":"Sotiropoulou","year":"2005","journal-title":"Arch Gynecol Obstet"},{"key":"2025042703162427000_2016.apr25_1.bcr2016214856.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2010.10.002"},{"key":"2025042703162427000_2016.apr25_1.bcr2016214856.6","first-page":"699","article-title":"Primary sarcoma of the adult vagina: a clinicopathologic study","volume":"65","author":"Peters","year":"1985","journal-title":"Obstet Gynecol"},{"key":"2025042703162427000_2016.apr25_1.bcr2016214856.7","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1827.2003.01442.x"},{"key":"2025042703162427000_2016.apr25_1.bcr2016214856.8","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(91)90153-G"},{"key":"2025042703162427000_2016.apr25_1.bcr2016214856.9","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(98)90394-X"},{"key":"2025042703162427000_2016.apr25_1.bcr2016214856.10","doi-asserted-by":"crossref","unstructured":"Siegal GP , Chhieng DC . Updates in diagnostic pathology. Berlin: Springer, 2005:12\u201314.","DOI":"10.1007\/0-387-32025-3"},{"key":"2025042703162427000_2016.apr25_1.bcr2016214856.11","unstructured":"Clarke B , Hale KS , Gilks CB , et al . Somatic mutation profiling of PI3K pathway in uterine carcinosarcoma\/malignant mixed M\u00fcllerian tumours, ESUN, A periodical for the sarcoma community. Jan 2014-Vol 11 Number 1."},{"key":"2025042703162427000_2016.apr25_1.bcr2016214856.12","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1998.5054"},{"key":"2025042703162427000_2016.apr25_1.bcr2016214856.13","first-page":"169","article-title":"Sarcomatoid carcinomas of the female genital tract (malignant mixed M\u00fcllerian tumours)","volume":"10","author":"Colombi","year":"1993","journal-title":"Semin Diagn Pathol"},{"key":"2025042703162427000_2016.apr25_1.bcr2016214856.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2010.11.039"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2016-214856","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T10:16:33Z","timestamp":1745748993000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2016-214856"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,25]]},"references-count":14,"alternative-id":["10.1136\/bcr-2016-214856"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2016-214856","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,25]]}}}