{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T04:37:18Z","timestamp":1754195838404,"version":"3.40.4"},"reference-count":14,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2016,4,12]]},"abstract":"<jats:p>A 55-year-old woman presented with a 3-week history of weakness. On examination, she had a heliotrope rash, V-neck and shawl signs. There was symmetric proximal muscle weakness, and 2\/5 strength in upper and lower extremities. Laboratory values showed CK 5836, CRP 14.9, erythrocyte sedimentation rate 49, lactate dehydrogenase 633, negative antinuclear antibodies and anti-Jo1 antibodies. Muscle biopsy and immunohistochemistry findings were consistent with dermatomyositis. Treatment with high-dose steroids, cyclophosphamide and intravenous immunoglobulin (IVIG) was started, without improvement of symptoms. She was found to have cold agglutinins with a cold screen titre of 1:256,256. Work up for malignancy ensued. Positron emission tomography\u2013computed tomography (PET-CT) showed increased uptake in the thyroid. Fine-needle thyroid biopsy with flow cytometry studies revealed atypical lymphocytes consistent with diffuse large B-cell lymphoma. The patient underwent R-CHOP therapy, with remarkable improvement of her symptoms. Dermatomyositis associated with primary thyroid lymphoma has not been previously reported. This case reinforces the importance of cancer screening in dermatomyositis patients.<\/jats:p>","DOI":"10.1136\/bcr-2016-215057","type":"journal-article","created":{"date-parts":[[2016,4,28]],"date-time":"2016-04-28T17:10:43Z","timestamp":1461863443000},"page":"bcr2016215057","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Primary thyroid lymphoma presenting as dermatomyositis: a first case and review of the literature"],"prefix":"10.1136","volume":"2016","author":[{"given":"Xinyu","family":"Nan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abimbola","family":"Adike","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence","family":"Rice","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viviane","family":"Bunin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2016,4,28]]},"reference":[{"key":"2025042703183444000_2016.apr28_1.bcr2016215057.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199202063260602"},{"key":"2025042703183444000_2016.apr28_1.bcr2016215057.2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1980.01640270055013"},{"key":"2025042703183444000_2016.apr28_1.bcr2016215057.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03540-6"},{"key":"2025042703183444000_2016.apr28_1.bcr2016215057.4","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.140566"},{"key":"2025042703183444000_2016.apr28_1.bcr2016215057.5","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20041367"},{"key":"2025042703183444000_2016.apr28_1.bcr2016215057.6","doi-asserted-by":"publisher","DOI":"10.4158\/EP13145.CR"},{"key":"2025042703183444000_2016.apr28_1.bcr2016215057.7","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-009-0858-y"},{"key":"2025042703183444000_2016.apr28_1.bcr2016215057.8","doi-asserted-by":"publisher","DOI":"10.1186\/1742-6413-2-21"},{"key":"2025042703183444000_2016.apr28_1.bcr2016215057.9","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9371.151139"},{"key":"2025042703183444000_2016.apr28_1.bcr2016215057.10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198503073121001"},{"key":"2025042703183444000_2016.apr28_1.bcr2016215057.11","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-002-0947-3"},{"key":"2025042703183444000_2016.apr28_1.bcr2016215057.12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03929.x"},{"key":"2025042703183444000_2016.apr28_1.bcr2016215057.13","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-005-0768-z"},{"key":"2025042703183444000_2016.apr28_1.bcr2016215057.14","doi-asserted-by":"publisher","DOI":"10.1089\/thy.1993.3.93"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2016-215057","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T10:18:45Z","timestamp":1745749125000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2016-215057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,28]]},"references-count":14,"alternative-id":["10.1136\/bcr-2016-215057"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2016-215057","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2016,4,28]]}}}