{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T08:39:53Z","timestamp":1769243993864,"version":"3.49.0"},"reference-count":16,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2018,1,25]]},"abstract":"<jats:p>The cytochrome P450 is a superfamily of isoenzymes that are responsible for the metabolism of many drugs. Significant changes in pharmacokinetics and drug interactions may be due to induction of hepatic cytochrome P450 enzymes. Rifampicin is a common inducer of CYP3A4. We report a case of a 57-year-old woman who was suspected for endocarditis and therefore treated with rifampicin. Due to previous mechanical aortic valve replacement, she also received phenprocoumon for anticoagulation. Although continuing anticoagulant therapy, antibiotic coadministration led to normal international normalised ratio (INR) level. Fifteen days after the treatment with rifampicin ended, INR returned to therapeutic level.<\/jats:p>","DOI":"10.1136\/bcr-2016-215155","type":"journal-article","created":{"date-parts":[[2018,2,12]],"date-time":"2018-02-12T08:55:10Z","timestamp":1518425710000},"page":"bcr-2016-215155","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Problems in anticoagulation of a patient with antibiotic treatment for endocarditis: interaction of rifampicin and vitamin K antagonists"],"prefix":"10.1136","volume":"2018","author":[{"given":"Lars","family":"Mizera","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr Kardiologie und Kreislauferkrankungen, Universit\u00e4tsklinikum T\u00fcbingen, Tuebingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Geisler","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Kardiologie und Kreislauferkrankungen, Universit\u00e4tsklinikum T\u00fcbingen, Tuebingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"M\u00f6rike","sequence":"additional","affiliation":[{"name":"Department fur Experimentelle und Klinische Pharmakologie und Toxikologie, Eberhard Karls Universitat Tubingen, T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meinrad","family":"Gawaz","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Kardiologie und Kreislauferkrankungen, Universit\u00e4tsklinikum T\u00fcbingen, Tuebingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Steeg","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Kardiologie und Kreislauferkrankungen, Universit\u00e4tsklinikum T\u00fcbingen, Tuebingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,2,12]]},"reference":[{"key":"2025082703335867000_2018.feb12_1.bcr-2016-215155.1","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/bcpt.12172","article-title":"A new algorithm for weekly phenprocoumon dose variation in a southern Brazilian population: role for CYP2C9, CYP3A4\/5 and VKORC1 genes polymorphisms","volume":"114","author":"Botton","year":"2014","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"2025082703335867000_2018.feb12_1.bcr-2016-215155.2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp285"},{"key":"2025082703335867000_2018.feb12_1.bcr-2016-215155.3","doi-asserted-by":"publisher","DOI":"10.1086\/313753"},{"key":"2025082703335867000_2018.feb12_1.bcr-2016-215155.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2014.02.002"},{"key":"2025082703335867000_2018.feb12_1.bcr-2016-215155.5","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2013.167"},{"key":"2025082703335867000_2018.feb12_1.bcr-2016-215155.6","doi-asserted-by":"crossref","first-page":"449","DOI":"10.5414\/CP202764","article-title":"Delayed de-induction of CYP2C9 compared to CYP3A after discontinuation of rifampicin: Report of two cases","volume":"55","author":"Shibata","year":"2017","journal-title":"Int J Clin Pharmacol Ther"},{"key":"2025082703335867000_2018.feb12_1.bcr-2016-215155.7","doi-asserted-by":"publisher","DOI":"10.1172\/JCI3703"},{"key":"2025082703335867000_2018.feb12_1.bcr-2016-215155.8","first-page":"391","article-title":"The effect of cytochrome P450 metabolism on drug response, interactions, and adverse effects","volume":"76","author":"Lynch","year":"2007","journal-title":"Am Fam Physician"},{"key":"2025082703335867000_2018.feb12_1.bcr-2016-215155.9","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs109"},{"key":"2025082703335867000_2018.feb12_1.bcr-2016-215155.10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1300615"},{"key":"2025082703335867000_2018.feb12_1.bcr-2016-215155.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2014.01.044"},{"key":"2025082703335867000_2018.feb12_1.bcr-2016-215155.12","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-010-0950-y"},{"key":"2025082703335867000_2018.feb12_1.bcr-2016-215155.13","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200847090-00002"},{"key":"2025082703335867000_2018.feb12_1.bcr-2016-215155.14","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-005-1150-x"},{"key":"2025082703335867000_2018.feb12_1.bcr-2016-215155.15","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-06-2111"},{"key":"2025082703335867000_2018.feb12_1.bcr-2016-215155.16","doi-asserted-by":"publisher","DOI":"10.1038\/nature02214"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2016-215155","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T10:34:10Z","timestamp":1756290850000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2016-215155"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,12]]},"references-count":16,"alternative-id":["10.1136\/bcr-2016-215155"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2016-215155","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,12]]}}}