{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T12:36:55Z","timestamp":1790339815943,"version":"4.1.0"},"reference-count":12,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2016,7,18]]},"abstract":"<jats:p><jats:italic>Clostridium sordellii<\/jats:italic>is a spore-forming anaerobic Gram-positive rod that has rarely been reported to cause disease in humans. Resultant mortality from infection is estimated at nearly 70% and is most often correlated with gynaecological procedures, intravenous drug abuse or trauma.<jats:italic>C. sordellii<\/jats:italic>infection often presents similarly to toxic shock syndrome (TSS); notable features of infection include refractory hypotension, haemoconcentration and marked leucocytosis. Although clinically similar to TSS, a notable difference is<jats:italic>C. sordellii<\/jats:italic>infections rarely involve fever. The organism's major toxins include haemorrhagic (TcsH) and lethal factor (TcsL), which function to disrupt cytoskeletal integrity. Current literature suggests treating<jats:italic>C. sordelli<\/jats:italic>infection with a broad-spectrum penicillin, metronidazole and clindamycin. We present a case of<jats:italic>C. sordellii<\/jats:italic>bacteraemia and septic shock in an immunocompromised patient who was recently diagnosed with pleomorphic gluteal sarcoma. Despite presenting in critical condition, the patient improved after aggressive hemodynamic resuscitation, source control and intravenous antibiotic therapy.<\/jats:p>","DOI":"10.1136\/bcr-2016-215240","type":"journal-article","created":{"date-parts":[[2016,8,3]],"date-time":"2016-08-03T15:42:29Z","timestamp":1470238949000},"page":"bcr2016215240","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Non-lethal<i>Clostridium sordellii<\/i>bacteraemia in an immunocompromised patient with pleomorphic sarcoma"],"prefix":"10.1136","volume":"2016","author":[{"given":"Alex K","family":"Bonnecaze","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah Ellen Elza","family":"Stephens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter John","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2016,8,3]]},"reference":[{"key":"2025042703495052000_2016.aug03_1.bcr2016215240.1","first-page":"838","article-title":"Un anaerobie agent de gangrene gazeuse","volume":"87","author":"Sordellii","year":"1922","journal-title":"C R Seances Soc Biol"},{"key":"2025042703495052000_2016.aug03_1.bcr2016215240.2","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-008-8192-y"},{"key":"2025042703495052000_2016.aug03_1.bcr2016215240.3","doi-asserted-by":"publisher","DOI":"10.1086\/508866"},{"key":"2025042703495052000_2016.aug03_1.bcr2016215240.4","doi-asserted-by":"publisher","DOI":"10.1086\/383471"},{"key":"2025042703495052000_2016.aug03_1.bcr2016215240.5","doi-asserted-by":"crossref","unstructured":"Tsokos M , Schalinski S , Paulsen F , et al . Pathology of fatal traumatic and nontraumatic clostridial gas gangrene: a histopathological, immunohistochemical, and ultrastructural study of six autopsy cases. Int J Legal Med 2008;122:35\u201341. doi:10.1007\/s00414-007-0163-9","DOI":"10.1007\/s00414-007-0163-9"},{"key":"2025042703495052000_2016.aug03_1.bcr2016215240.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.resmic.2014.09.003"},{"key":"2025042703495052000_2016.aug03_1.bcr2016215240.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.anaerobe.2013.08.009"},{"key":"2025042703495052000_2016.aug03_1.bcr2016215240.8","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.03414-14"},{"key":"2025042703495052000_2016.aug03_1.bcr2016215240.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.anaerobe.2011.06.009"},{"key":"2025042703495052000_2016.aug03_1.bcr2016215240.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.anaerobe.2009.06.002"},{"key":"2025042703495052000_2016.aug03_1.bcr2016215240.11","doi-asserted-by":"publisher","DOI":"10.1086\/652774"},{"key":"2025042703495052000_2016.aug03_1.bcr2016215240.12","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00933-11"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2016-215240","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T10:50:00Z","timestamp":1745751000000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2016-215240"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,3]]},"references-count":12,"alternative-id":["10.1136\/bcr-2016-215240"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2016-215240","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,3]]}}}