{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T12:19:38Z","timestamp":1767183578216,"version":"3.44.0"},"reference-count":16,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2016,5,11]]},"abstract":"<jats:p>Initial treatment of chronic phase chronic myeloid leukaemia is straightforward in today's era of tyrosine kinase inhibitors. However, managing refractory cases remain a major challenge due to the multiple factors that can influence decision-making, including medication tolerance, disease burden, mutation status, comorbidities, availability of donor, and fitness for an ablative conditioning. We report a male patient presenting with chronic phase chronic myeloid leukaemia who was treated with 5 different tyrosine kinase inhibitors either due to intolerance and\/or failed response. He subsequently received 2 haploidentical haematopoietic stem cells transplants before achieving complete remission. This case highlights various treatment options, need for vigilant disease monitoring, and the possibility of complete positive response even after many lines of therapy failure.<\/jats:p>","DOI":"10.1136\/bcr-2016-215370","type":"journal-article","created":{"date-parts":[[2016,6,23]],"date-time":"2016-06-23T19:26:40Z","timestamp":1466710000000},"page":"bcr2016215370","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Case of relentless chronic phase of chronic myeloid leukaemia"],"prefix":"10.1136","volume":"2016","author":[{"given":"Onyee","family":"Chan","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, University of Arizona Medical Center\u2014University Campus, Tucson, Arizona, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Arizona Medical Center\u2014University Campus, Tucson, Arizona, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravitharan","family":"Krishnadasan","sequence":"additional","affiliation":[{"name":"Department of Hematology Oncology, University of Arizona Medical Center\u2014University Campus, Tucson, Arizona, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faiz","family":"Anwer","sequence":"additional","affiliation":[{"name":"Department of Hematology Oncology, University of Arizona Medical Center\u2014University Campus, Tucson, Arizona, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2016,6,22]]},"reference":[{"unstructured":"SEER Stat Fact Sheets: Chronic Myeloid Leukemia (CML): Surveillance, Epidemiology, and End Results (SEER) of National Cancer Institute (NCI). 2016 (cited 24 February 2016). http:\/\/seer.cancer.gov\/statfacts\/html\/cmyl.html","key":"2025082804250581000_2016.jun22_1.bcr2016215370.1"},{"doi-asserted-by":"publisher","key":"2025082804250581000_2016.jun22_1.bcr2016215370.2","DOI":"10.1200\/JCO.2011.34.7146"},{"doi-asserted-by":"crossref","unstructured":"Deininger MW . Diagnosing and managing advanced chronic myeloid leukemia. Am Soc Clin Oncol Educ Book 2015:e381\u20138. doi:10.14694\/EdBook_AM.2015.35.e381","key":"2025082804250581000_2016.jun22_1.bcr2016215370.3","DOI":"10.14694\/EdBook_AM.2015.35.e381"},{"doi-asserted-by":"publisher","key":"2025082804250581000_2016.jun22_1.bcr2016215370.4","DOI":"10.1056\/NEJM199907153410306"},{"doi-asserted-by":"publisher","key":"2025082804250581000_2016.jun22_1.bcr2016215370.5","DOI":"10.1097\/MOH.0000000000000224"},{"doi-asserted-by":"publisher","key":"2025082804250581000_2016.jun22_1.bcr2016215370.6","DOI":"10.1016\/j.bbmt.2012.08.014"},{"doi-asserted-by":"publisher","key":"2025082804250581000_2016.jun22_1.bcr2016215370.7","DOI":"10.1182\/blood-2012-03-378919"},{"doi-asserted-by":"publisher","key":"2025082804250581000_2016.jun22_1.bcr2016215370.8","DOI":"10.3109\/10428194.2015.1058937"},{"doi-asserted-by":"publisher","key":"2025082804250581000_2016.jun22_1.bcr2016215370.9","DOI":"10.1182\/blood-2015-06-641043"},{"doi-asserted-by":"publisher","key":"2025082804250581000_2016.jun22_1.bcr2016215370.10","DOI":"10.1007\/s00277-015-2322-2"},{"doi-asserted-by":"publisher","key":"2025082804250581000_2016.jun22_1.bcr2016215370.11","DOI":"10.2146\/ajhp140686"},{"doi-asserted-by":"publisher","key":"2025082804250581000_2016.jun22_1.bcr2016215370.12","DOI":"10.1002\/ajh.23887"},{"issue":"2","key":"2025082804250581000_2016.jun22_1.bcr2016215370.13","doi-asserted-by":"crossref","first-page":"S177","DOI":"10.1007\/s00277-015-2313-3","article-title":"The role of hematopoietic stem cell transplantation in chronic myeloid leukemia","volume":"94","author":"Gratwohl","year":"2015","journal-title":"Ann Hematol"},{"doi-asserted-by":"publisher","key":"2025082804250581000_2016.jun22_1.bcr2016215370.14","DOI":"10.1182\/blood-2014-10-567784"},{"doi-asserted-by":"publisher","key":"2025082804250581000_2016.jun22_1.bcr2016215370.15","DOI":"10.1038\/bmt.2015.93"},{"doi-asserted-by":"publisher","key":"2025082804250581000_2016.jun22_1.bcr2016215370.16","DOI":"10.1182\/blood-2013-05-501569"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2016-215370","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T11:25:17Z","timestamp":1756380317000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2016-215370"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,22]]},"references-count":16,"alternative-id":["10.1136\/bcr-2016-215370"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2016-215370","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2016,6,22]]}}}