{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T01:00:45Z","timestamp":1783472445818,"version":"3.55.0"},"reference-count":17,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2016,8,13]]},"abstract":"<jats:p>We present a case of a 56-year-old woman with Crohn's disease, treated with methotrexate and infliximab, who inadvertently received yellow fever vaccination (YFV) prior to a journey to Tanzania. She was not previously vaccinated against YF. YFV contains live-attenuated virus, and is contraindicated in patients treated with immunosuppressive drugs. Following vaccination, the patient fell ill with influenza-like illness. Elevated transaminase levels and YF viremia were detected. Despite being immunocompromised, the patient did not develop more severe adverse effects. Neutralising antibodies to YF virus were detected on day 14 following vaccination and remained protective at least 10\u2005months after vaccination. Limited data is available on outcomes of YFV in patients receiving immunosuppressive therapy, including biologics, and we report this case as a reminder of vigilance of vaccine recommendations in this population.<\/jats:p>","DOI":"10.1136\/bcr-2016-215403","type":"journal-article","created":{"date-parts":[[2016,8,29]],"date-time":"2016-08-29T15:48:02Z","timestamp":1472485682000},"page":"bcr2016215403","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":13,"title":["Inadvertent yellow fever vaccination of a patient with Crohn's disease treated with infliximab and methotrexate"],"prefix":"10.1136","volume":"2016","author":[{"given":"Christina","family":"Ekenberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Friis-M\u00f8ller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Ulstrup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"Aalykke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2016,8,29]]},"reference":[{"key":"2025042703563528000_2016.aug29_1.bcr2016215403.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2013.04.007"},{"key":"2025042703563528000_2016.aug29_1.bcr2016215403.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2013.12.013"},{"key":"2025042703563528000_2016.aug29_1.bcr2016215403.3","first-page":"1","article-title":"General recommendations on immunization: recommendations of the Advisory Committee on Immunization Practices (ACIP)","volume":"60","author":"Kroger","year":"2011","journal-title":"MMWR Recomm Rep"},{"key":"2025042703563528000_2016.aug29_1.bcr2016215403.4","unstructured":"CDC Health information for international travel 2016 (the Yellow Book 2016). http:\/\/wwwnc.cdc.gov\/travel\/yellowbook\/2016\/advising-travelers-with-specific-needs\/immunocompromised-travelers (accessed 27 Feb 2016)."},{"key":"2025042703563528000_2016.aug29_1.bcr2016215403.5","doi-asserted-by":"publisher","DOI":"10.1586\/erv.12.6"},{"issue":"(RR-07)","key":"2025042703563528000_2016.aug29_1.bcr2016215403.6","first-page":"1","article-title":"Yellow fever vaccine: recommendations of the Advisory Committee on Immunization Practices (ACIP)","volume":"59","author":"Staples","year":"2010","journal-title":"MMWR Recomm Rep"},{"key":"2025042703563528000_2016.aug29_1.bcr2016215403.7","doi-asserted-by":"crossref","unstructured":"Monath T , Cetron MS , Teuwen DE . Yellow fever vaccine. In: Plotkin SA , Orenstein WA , Offit PA, eds . Vaccines. 5th edn. Philadelphia, PA: Saunders Elsevier, 2008;959\u20131055.","DOI":"10.1016\/B978-1-4160-3611-1.50040-4"},{"key":"2025042703563528000_2016.aug29_1.bcr2016215403.8","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1002\/acr.20045","article-title":"Yellow fever revaccination during infliximab therapy","volume":"62","author":"Scheinberg","year":"2010","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"2025042703563528000_2016.aug29_1.bcr2016215403.9","doi-asserted-by":"publisher","DOI":"10.1111\/jtm.12209"},{"key":"2025042703563528000_2016.aug29_1.bcr2016215403.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2016.01.037"},{"key":"2025042703563528000_2016.aug29_1.bcr2016215403.11","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9071(199810)56:2<159::AID-JMV10>3.0.CO;2-B"},{"key":"2025042703563528000_2016.aug29_1.bcr2016215403.12","unstructured":"http:\/\/www.who.int\/mediacentre\/factsheets\/fs100\/en\/ (accessed 1 Dec 2015)."},{"key":"2025042703563528000_2016.aug29_1.bcr2016215403.13","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.13-0264"},{"key":"2025042703563528000_2016.aug29_1.bcr2016215403.14","unstructured":"World Health Organization. Yellow fever vaccination booster not needed. Geneva: WHO, 2013. http:\/\/www.who.int\/mediacentre\/news\/releases\/2013\/yellow_fever_20130517\/en\/ (accessed 1 Dec 2015)."},{"key":"2025042703563528000_2016.aug29_1.bcr2016215403.15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2015.05.025"},{"key":"2025042703563528000_2016.aug29_1.bcr2016215403.16","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1016\/S0140-6736(16)30116-7","article-title":"Yellow fever: a global reckoning","volume":"387","year":"2016","journal-title":"Lancet"},{"key":"2025042703563528000_2016.aug29_1.bcr2016215403.17","first-page":"20","volume-title":"Epidemiology and prevention of vaccine-preventable diseases","volume":"2","author":"Centers for Disease Control and Prevention","year":"2015"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2016-215403","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T10:56:45Z","timestamp":1745751405000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2016-215403"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,29]]},"references-count":17,"alternative-id":["10.1136\/bcr-2016-215403"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2016-215403","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,29]]}}}