{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T04:01:34Z","timestamp":1745812894287,"version":"3.40.4"},"reference-count":25,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2016,5,31]]},"abstract":"<jats:p>We report a case of a 60-year-old man who was referred to a palliative care clinic with monoclonal gammopathy of undetermined significance (MGUS)-associated neuropathy, responding to a therapeutic trial of warfarin. Electromyography showed distal symmetric sensory axonal neuropathy. The patient reported having had improvement of his neuropathic symptoms while taking warfarin postoperatively for thromboprophylaxis 1\u2005year prior, and recurrence of his symptoms after the warfarin was discontinued. The patient was rechallenged with a trial of warfarin, targeting an international normalised ratio of 1.5\u20132.0. His pain scores decreased from 5\/10 to 3\/10 at 1\u2005month and symptom improvement was maintained through 24\u2005months of follow-up. Warfarin had a remarkable impact on our patient's symptoms and quality of life. The mechanisms mediating the symptomatic benefit with warfarin are unclear; however, a placebo effect is unlikely. Further studies may help guide the use of warfarin for MGUS-associated neuropathy.<\/jats:p>","DOI":"10.1136\/bcr-2016-215518","type":"journal-article","created":{"date-parts":[[2016,6,17]],"date-time":"2016-06-17T12:41:26Z","timestamp":1466167286000},"page":"bcr2016215518","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Warfarin improves neuropathy in monoclonal gammopathy of undetermined significance"],"prefix":"10.1136","volume":"2016","author":[{"given":"Teny","family":"Henry Gomez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beata","family":"Holkova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"Noreika","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Egidio","family":"Del Fabbro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2016,6,17]]},"reference":[{"key":"2025042703362349000_2016.jun17_1.bcr2016215518.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa054494"},{"key":"2025042703362349000_2016.jun17_1.bcr2016215518.2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(78)90522-3"},{"key":"2025042703362349000_2016.jun17_1.bcr2016215518.3","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04355.x"},{"key":"2025042703362349000_2016.jun17_1.bcr2016215518.4","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/j.1600-0404.1992.tb06033.x","article-title":"Peripheral neuropathy in monoclonal gammopathy of undetermined significance: prevalence and immunopathogenetic studies","volume":"85","author":"Nobile-Orazio","year":"1992","journal-title":"Acta Neurol Scand"},{"key":"2025042703362349000_2016.jun17_1.bcr2016215518.5","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(93)90297-C"},{"key":"2025042703362349000_2016.jun17_1.bcr2016215518.6","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.33.7.617"},{"key":"2025042703362349000_2016.jun17_1.bcr2016215518.7","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/117.6.1385"},{"key":"2025042703362349000_2016.jun17_1.bcr2016215518.8","doi-asserted-by":"publisher","DOI":"10.1097\/00019052-199610000-00003"},{"key":"2025042703362349000_2016.jun17_1.bcr2016215518.9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2008.02246.x"},{"key":"2025042703362349000_2016.jun17_1.bcr2016215518.10","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.48.2.321"},{"key":"2025042703362349000_2016.jun17_1.bcr2016215518.11","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1101(1999)14:3<149::AID-JCA8>3.0.CO;2-9"},{"key":"2025042703362349000_2016.jun17_1.bcr2016215518.12","first-page":"351","article-title":"Paraproteinaemic demyelinating neuropathies","volume-title":"European handbook of neurological management","volume":"1","author":"Hadden","year":"2011"},{"key":"2025042703362349000_2016.jun17_1.bcr2016215518.13","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.47.5.1227"},{"key":"2025042703362349000_2016.jun17_1.bcr2016215518.14","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.66.5.575"},{"key":"2025042703362349000_2016.jun17_1.bcr2016215518.15","doi-asserted-by":"crossref","unstructured":"Allen D , Lunn MP , Niermeijer J , et al . 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