{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T17:19:51Z","timestamp":1758820791453,"version":"3.44.0"},"reference-count":6,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2016,4,25]]},"abstract":"<jats:p>BCG is an attenuated live strain of <jats:italic>Mycobacterium bovis<\/jats:italic> that is used as an intravesical immunotherapy for superficial bladder cancer. Although generally well tolerated, BCG instillation can lead to systemic diseases. We present a case of a 75-year-old man who was treated for recurrent localised transitional cell carcinoma (TCC) of the bladder with intravesical instillation of BCG in 2006. His medical history included Parkinson's disease. The patient reported worsening of Parkinson symptoms in the preceding month. In addition, he had progressive pancytopaenia and a bone marrow biopsy showed a granulomatous inflammatory infiltrate. Cultures from bone marrow aspiration grew <jats:italic>M. bovis<\/jats:italic>. He was successfully treated with tuberculostatic drugs and made a full recovery. In addition, there was partial amelioration of the Parkinson symptoms. This case shows that physicians should be aware that BCG instillation for TCC can cause systemic disease even years after treatment.<\/jats:p>","DOI":"10.1136\/bcr-2016-215599","type":"journal-article","created":{"date-parts":[[2016,5,11]],"date-time":"2016-05-11T05:02:33Z","timestamp":1462942953000},"page":"bcr2016215599","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Systemic BCG infection in a patient with pancytopaenia and fever 9\u2005years after intravesical BCG administration for bladder cancer"],"prefix":"10.1136","volume":"2016","author":[{"given":"Ine M","family":"Westhovens","sequence":"first","affiliation":[{"name":"Department of Geriatrics, Jessa Ziekenhuis, Hasselt, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Elena","family":"Vanden Abeele","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Jessa Ziekenhuis, Hasselt, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter E","family":"Messiaen","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Immunity, Jessa Ziekenhuis, Hasselt, Belgium"},{"name":"BIOMED Research Institute, Universiteit Hasselt, Hasselt, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeroen CH","family":"van der Hilst","sequence":"additional","affiliation":[{"name":"BIOMED Research Institute, Universiteit Hasselt, Hasselt, Belgium"},{"name":"Jessa Ziekenhuis, Hasselt, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2016,5,11]]},"reference":[{"key":"2025082623121499000_2016.may11_1.bcr2016215599.1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.12075"},{"key":"2025082623121499000_2016.may11_1.bcr2016215599.2","first-page":"957","article-title":"[Complications of endovesical treatment with BCG in a series of 200 patients]","volume":"52","author":"Resel Folkersma","year":"1999","journal-title":"Arch Esp Urol"},{"key":"2025082623121499000_2016.may11_1.bcr2016215599.3","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1159\/000471561","article-title":"Systematic bacillus Calmette-Gu\u00e9rin infection, \u2032BCGitis\u2032, in patients treated by intravesical bacillus Calmette-Gu\u00e9rin therapy for bladder cancer","volume":"16","author":"Steg","year":"1989","journal-title":"Eur Urol"},{"key":"2025082623121499000_2016.may11_1.bcr2016215599.4","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000119"},{"key":"2025082623121499000_2016.may11_1.bcr2016215599.5","doi-asserted-by":"crossref","first-page":"671","DOI":"10.7863\/jum.2007.26.5.671","article-title":"Tuberculous epididymo-orchitis after intravesical BCG therapy for superficial bladder carcinoma: sonographic findings","volume":"26","author":"Salvador","year":"2007","journal-title":"J Ultrasound Med"},{"key":"2025082623121499000_2016.may11_1.bcr2016215599.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2008.10.011"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2016-215599","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T06:12:22Z","timestamp":1756275142000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2016-215599"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,11]]},"references-count":6,"alternative-id":["10.1136\/bcr-2016-215599"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2016-215599","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2016,5,11]]}}}