{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T06:40:05Z","timestamp":1756276805144,"version":"3.44.0"},"reference-count":15,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2016,4,21]]},"abstract":"<jats:p>Breast cancer in men is uncommon, accounting for &lt;1% of all breast cancers. Even though lobular structures are quite infrequent in the male breast, rare cases of invasive lobular breast carcinoma have been described, representing 1\u20132% of all breast cancers in men. Risk factors include undescended testes, congenital inguinal hernia, orchiectomy, orchitis, testicular injury, infertility and Klinefelter's syndrome, previous thoracic radiotherapy, alterations of the oestrogen\u2013testosterone ratio and familial history (BRCA 2 and 1). The authors present a case of a 52-year-old man with no relevant predisposing factors to breast cancer, who presented with a painless, firm nodule, fixed to the nipple on the left breast, associated with nipple retraction and ulceration, and fully characterised by mammogram and ultrasound. Histopathological and immunohistochemical analysis revealed the diagnosis of invasive lobular breast carcinoma and the patient underwent left radical mastectomy, followed by adjuvant chemotherapy, radiotherapy and hormonotherapy. A brief review of the literature is presented.<\/jats:p>","DOI":"10.1136\/bcr-2016-215665","type":"journal-article","created":{"date-parts":[[2016,5,5]],"date-time":"2016-05-05T09:28:09Z","timestamp":1462440489000},"page":"bcr2016215665","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Invasive lobular carcinoma: a rare presentation in the male breast"],"prefix":"10.1136","volume":"2016","author":[{"given":"Elisa","family":"Melo Abreu","sequence":"first","affiliation":[{"name":"Department of Radiology, Instituto Portugu\u00eas de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of Radiology, Instituto Portugu\u00eas de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Carlos","family":"Marques","sequence":"additional","affiliation":[{"name":"Department of Radiology, Instituto Portugu\u00eas de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gon\u00e7alo","family":"Esteves","sequence":"additional","affiliation":[{"name":"Pathology Department, Instituto Portugu\u00eas de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2016,5,5]]},"reference":[{"key":"2025082623202239000_2016.may05_1.bcr2016215665.1","first-page":"365","article-title":"Invasive lobular carcinoma of the male breast","volume":"49","author":"Erhan","year":"2006","journal-title":"Can J Surg"},{"key":"2025082623202239000_2016.may05_1.bcr2016215665.2","doi-asserted-by":"publisher","DOI":"10.1159\/000190078"},{"key":"2025082623202239000_2016.may05_1.bcr2016215665.3","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2014.139"},{"key":"2025082623202239000_2016.may05_1.bcr2016215665.4","doi-asserted-by":"publisher","DOI":"10.1148\/rg.332125208"},{"key":"2025082623202239000_2016.may05_1.bcr2016215665.5","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.165.1.7785634"},{"key":"2025082623202239000_2016.may05_1.bcr2016215665.6","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-137-8-200210150-00013"},{"key":"2025082623202239000_2016.may05_1.bcr2016215665.7","doi-asserted-by":"publisher","DOI":"10.1148\/rg.333125137"},{"key":"2025082623202239000_2016.may05_1.bcr2016215665.8","doi-asserted-by":"publisher","DOI":"10.7150\/jca.4091"},{"key":"2025082623202239000_2016.may05_1.bcr2016215665.9","first-page":"183","article-title":"Male breast cancer","volume":"3","author":"Rudlowki","year":"2008","journal-title":"Breast Care (Basel)"},{"key":"2025082623202239000_2016.may05_1.bcr2016215665.10","first-page":"1441","article-title":"Pleomorphic lobular carcinoma in a male breast: a case report with review of the literature","volume":"6","author":"Ishida","year":"2013","journal-title":"Int J Exp Pathol"},{"key":"2025082623202239000_2016.may05_1.bcr2016215665.11","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6890-14-16"},{"key":"2025082623202239000_2016.may05_1.bcr2016215665.12","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2008.49.6.978"},{"key":"2025082623202239000_2016.may05_1.bcr2016215665.13","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21526"},{"key":"2025082623202239000_2016.may05_1.bcr2016215665.14","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20312"},{"key":"2025082623202239000_2016.may05_1.bcr2016215665.15","doi-asserted-by":"publisher","DOI":"10.1023\/B:BREA.0000010701.08825.2d"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2016-215665","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T06:20:36Z","timestamp":1756275636000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2016-215665"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,5]]},"references-count":15,"alternative-id":["10.1136\/bcr-2016-215665"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2016-215665","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2016,5,5]]}}}