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We describe a very rare and novel case of a distally located vaginal carcinoma with metastasis to the breast Federation of Gynecology and Obstetrics (FIGO) stage IV (FIGO IVB). Robot-assisted extrafascial total hysterectomy with local vaginal mass excision and partial mastectomy of the left breast were performed. After surgery, the patient underwent adjuvant chemotherapy followed by breast and pelvic radiotherapy, with maintained complete remission after 3\u2005years of follow-up. This combination of findings and treatment is very distinct with a unique and favourable response.<\/jats:p>","DOI":"10.1136\/bcr-2016-215895","type":"journal-article","created":{"date-parts":[[2016,7,21]],"date-time":"2016-07-21T09:52:43Z","timestamp":1469094763000},"page":"bcr2016215895","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Breast metastasis from vaginal cancer"],"prefix":"10.1136","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0579-5549","authenticated-orcid":false,"given":"Neeraja","family":"Chandrasekaran","sequence":"first","affiliation":[{"name":"Cleveland Clinic Florida, Weston, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Scharifker","sequence":"additional","affiliation":[{"name":"Department of Pathology, West Boca Medical Center, Boca Raton, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Varsegi","sequence":"additional","affiliation":[{"name":"Department of Pathology, West Boca Medical Center, Boca Raton, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoyla","family":"Almeida","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, West Boca Medical Center, Boca Raton, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2016,7,21]]},"reference":[{"key":"2025082704070186000_2016.jul21_1.bcr2016215895.1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21254"},{"key":"2025082704070186000_2016.jul21_1.bcr2016215895.2","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1097\/00001703-200502000-00013","article-title":"Vaginal cancers","volume":"17","author":"Creasman","year":"2005","journal-title":"Curr Opin Obstet Gynecol"},{"key":"2025082704070186000_2016.jul21_1.bcr2016215895.3","first-page":"1112-16","article-title":"Primary carcinoma of the vagina","volume":"96","author":"Dunn","year":"1996","journal-title":"Am J Obstet Gynecol"},{"key":"2025082704070186000_2016.jul21_1.bcr2016215895.4","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70207-2"},{"key":"2025082704070186000_2016.jul21_1.bcr2016215895.5","first-page":"4091","article-title":"The accuracy of intraoperative frozen section of the inguinal sentinel lymph node in vulvar cancer","volume":"28","author":"Brunner","year":"2008","journal-title":"Anticancer Res"},{"key":"2025082704070186000_2016.jul21_1.bcr2016215895.6","first-page":"19367689","article-title":"New FIGO staging for carcinoma of vulva, cervix, endometrium, and sarcomas","volume":"105","author":"Pecorelli","year":"2005","journal-title":"Int J Gynaecol Obstet"},{"key":"2025082704070186000_2016.jul21_1.bcr2016215895.7","unstructured":"Dizon D , Campos S . 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