{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:15:39Z","timestamp":1762506939790,"version":"3.44.0"},"reference-count":13,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2016,10,17]]},"abstract":"<jats:p>Androgen-secreting ovarian tumours are extremely rare accounting for &lt;5% of all ovarian neoplasms. They are more frequent in postmenopausal women and should be suspected in the case of a rapid onset of androgenic symptoms. We report 4 cases of postmenopausal women who presented with signs of virilisation. All patients revealed increased serum levels of testosterone, normal dehydroepiandrosterone-sulfate and negative pelvic ultrasound for adnexal masses. An androgen-secreting ovarian tumour was suspected and all of them were submitted to bilateral oophorectomy. Histology confirmed the diagnosis of Leydig cell tumours in 3 patients and mature teratoma in 1. A successful response to surgery, which includes a decline in serum androgen levels and signs of hyperandrogenism, was observed in our patients. This case series demonstrates that androgen-secreting ovarian neoplasms may not be detectable by imaging studies, but should be considered in the differential diagnosis of all postmenopausal women with signs of hyperandrogenism.<\/jats:p>","DOI":"10.1136\/bcr-2016-215985","type":"journal-article","created":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T11:02:52Z","timestamp":1477998172000},"page":"bcr2016215985","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Leydig cell tumour and mature ovarian teratoma: rare androgen-secreting ovarian tumours in postmenopausal women"],"prefix":"10.1136","volume":"2016","author":[{"given":"Ana","family":"Palha","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Centro Hospitalar de Lisboa Central, Lisbon, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu\u00edsa","family":"Cortez","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Centro Hospitalar de Lisboa Central, Lisbon, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Paula","family":"Tavares","sequence":"additional","affiliation":[{"name":"Department of Surgery, Centro Hospitalar Lisboa Central, Lisbon, Portugal, Centro Hospitalar de Lisboa Central, Lisboa, Lisboa, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Agapito","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Centro Hospitalar de Lisboa Central, Lisbon, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2016,11,1]]},"reference":[{"key":"2025082804440120000_2016.nov01_1.bcr2016215985.1","doi-asserted-by":"publisher","DOI":"10.1590\/0004-2730000002461"},{"key":"2025082804440120000_2016.nov01_1.bcr2016215985.2","doi-asserted-by":"publisher","DOI":"10.1148\/rg.304095745"},{"key":"2025082804440120000_2016.nov01_1.bcr2016215985.3","first-page":"130030","article-title":"Steroid cell tumor: a rare cause of hirsutism in a female","volume":"2013","author":"Swain","year":"2013","journal-title":"Endocrinol Diabetes Metab Case Rep"},{"key":"2025082804440120000_2016.nov01_1.bcr2016215985.4","first-page":"152","article-title":"Leydig cell tumour of the ovary\u2014a case report","volume":"16","author":"Freitas","year":"2014","journal-title":"Revista da Faculdade de Ci\u00eancias M\u00e9dicas de Sorocaba"},{"key":"2025082804440120000_2016.nov01_1.bcr2016215985.5","doi-asserted-by":"crossref","first-page":"e39","DOI":"10.1016\/j.jpag.2008.05.012","article-title":"Virilizing ovarian dermoid cyst with leydig cells","volume":"22","author":"Hoffman","year":"2009","journal-title":"J Pediatr Adolesc Gynecol"},{"key":"2025082804440120000_2016.nov01_1.bcr2016215985.6","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1683"},{"key":"2025082804440120000_2016.nov01_1.bcr2016215985.7","first-page":"130","article-title":"Virilization due to androgen hypersecretion in a patient with ovarian leydig cell tumor: diagnostic and psychosocial implications","volume":"45","author":"Juniarto","year":"2013","journal-title":"Acta Med Indones"},{"key":"2025082804440120000_2016.nov01_1.bcr2016215985.8","doi-asserted-by":"publisher","DOI":"10.1186\/2054-7099-1-7"},{"key":"2025082804440120000_2016.nov01_1.bcr2016215985.9","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-1-182"},{"key":"2025082804440120000_2016.nov01_1.bcr2016215985.10","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-09-0576"},{"key":"2025082804440120000_2016.nov01_1.bcr2016215985.11","unstructured":"National Comprehensive Cancer Network. 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