{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:04:38Z","timestamp":1790827478192,"version":"4.1.0"},"reference-count":16,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2016,7,19]]},"abstract":"<jats:p>Leprosy is a chronic infectious disease caused by <jats:italic>Mycobacterium leprae<\/jats:italic>. The main clinical manifestations involve the skin and the peripheral nervous system. Several types of nephropathy have been described in leprosy. One frequent form of renal involvement is amyloidosis, especially in patients with lepromatous leprosy. In these patients, end-stage renal disease is an important contributor to morbidity and mortality. Here, we present the case of a patient with nephrotic syndrome caused by secondary amyloidosis, chronic peripheral neuropathy and a history of leprosy. The patient was correctly treated in her youth, which is the best way to avoid renal pathology, but she developed a nephrotic syndrome years later.<\/jats:p>","DOI":"10.1136\/bcr-2016-216038","type":"journal-article","created":{"date-parts":[[2016,8,3]],"date-time":"2016-08-03T11:42:47Z","timestamp":1470224567000},"page":"bcr2016216038","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Renal amyloidosis in leprosy, an infrequent cause of nephrotic syndrome in Europe"],"prefix":"10.1136","volume":"2016","author":[{"given":"Noelia","family":"Sanz-Mart\u00edn","sequence":"first","affiliation":[{"name":"Department of Nephrologist, Hospital Universitario Principe de Asturias, Alcala de Henares, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly del Roc\u00edo","family":"Samill\u00e1n-Sosa","sequence":"additional","affiliation":[{"name":"Department of Nephrologist, Hospital Universitario Principe de Asturias, Alcala de Henares, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"De Miguel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital Universitario Principe de Asturias, Alcala de Henares, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Mart\u00ednez-Miguel","sequence":"additional","affiliation":[{"name":"Department of Nephrologist, Hospital Universitario Principe de Asturias, Alcala de Henares, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2016,8,3]]},"reference":[{"key":"2025082707371117000_2016.aug03_1.bcr2016216038.1","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1681\/ASN.V581546","article-title":"Leprosy-associated renal disease: case report and review of the literature","volume":"5","author":"Ahsan","year":"1995","journal-title":"J Am Soc Nephrol"},{"key":"2025082707371117000_2016.aug03_1.bcr2016216038.2","unstructured":"Gelber RH . Leprosy (Hansen's disease). In: Braunwald E , ed. Harrison principles of internal medicine. 15th edn. Madrid: McGraw-Hill, 2001:1222\u201333."},{"key":"2025082707371117000_2016.aug03_1.bcr2016216038.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)15952-7"},{"key":"2025082707371117000_2016.aug03_1.bcr2016216038.4","first-page":"389","article-title":"Global leprosy update, 2013; reducing disease burden","volume":"36","year":"2014","journal-title":"Wkly Epidemiol Rec"},{"key":"2025082707371117000_2016.aug03_1.bcr2016216038.5","unstructured":"Hansen AG , Looft C . Die lepar vom clinischen und pathologisch anatomischen standpankte. Cassel TG, Ed Fisher and Co., 1894:45 (translated by N. Walker.Bristol: John Wright and Co, 1895."},{"key":"2025082707371117000_2016.aug03_1.bcr2016216038.6","first-page":"53","article-title":"A study of one hundred fifty autopsies on cases of leprosy","volume":"5","author":"Mitsuda","year":"1937","journal-title":"Int J Lepr"},{"key":"2025082707371117000_2016.aug03_1.bcr2016216038.7","first-page":"107","article-title":"Renal involvement in leprosy. Retrospective analysis of 461 cases in Brazil","volume":"10","author":"Bezerra","year":"2006","journal-title":"Braz J Infect Dis"},{"key":"2025082707371117000_2016.aug03_1.bcr2016216038.8","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2001.25177"},{"key":"2025082707371117000_2016.aug03_1.bcr2016216038.9","first-page":"455","article-title":"Renal lesions and other major findings in necropsies of 133 patients with leprosy","volume":"53","author":"Date","year":"1985","journal-title":"Int J Lepr Other Mycobsct Dis"},{"key":"2025082707371117000_2016.aug03_1.bcr2016216038.10","first-page":"32","article-title":"A review of post-mortem findings in 37 cases of leprosy","volume":"36","author":"Desikan","year":"1968","journal-title":"Int Lepr Other Mycobact Dis"},{"key":"2025082707371117000_2016.aug03_1.bcr2016216038.11","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/76.3.321"},{"key":"2025082707371117000_2016.aug03_1.bcr2016216038.12","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(89)80027-7"},{"key":"2025082707371117000_2016.aug03_1.bcr2016216038.13","unstructured":"Cerulli N , De Angelis S , Sebastiani A . Lepromatous nephropathy. In: Cerulli N , De Angelis S , Sebastiani A , eds. Tropical renal and urological diseases. Milan: Wichtig Editore, 1996:56\u20139."},{"key":"2025082707371117000_2016.aug03_1.bcr2016216038.14","first-page":"171","article-title":"Acute renal failure in leprosy","volume":"45","author":"Singhal","year":"1977","journal-title":"Int J Lepr"},{"key":"2025082707371117000_2016.aug03_1.bcr2016216038.15","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1159\/000187517","article-title":"Renal abnormalities in leprosy","volume":"65","author":"Kirsztajn","year":"1993","journal-title":"Nephron"},{"key":"2025082707371117000_2016.aug03_1.bcr2016216038.16","first-page":"282","article-title":"Inmune complexes in glomeruli of patients with leprosy","volume":"42","author":"Shwe","year":"1972","journal-title":"Lepr Rev"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2016-216038","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T14:37:18Z","timestamp":1756305438000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2016-216038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,3]]},"references-count":16,"alternative-id":["10.1136\/bcr-2016-216038"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2016-216038","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,3]]}}}