{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T08:28:31Z","timestamp":1762504111725,"version":"3.44.0"},"reference-count":29,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2016,6,28]]},"abstract":"<jats:p>Primary hyperaldosteronism is one of the most common causes of secondary hypertension but clear differentiation between its various subtypes can be a clinical challenge. We report the case of a 37-year-old African-American woman with refractory hypertension who was admitted to our hospital for palpitations, shortness of breath and headache. Her laboratory results showed hypokalaemia and an elevated aldosterone\/renin ratio. An abdominal CT scan showed a nodule in the left adrenal gland but adrenal venous sampling showed elevated aldosterone\/renin ratio from the right adrenal vein. The patient began a new medical regimen but declined any surgical options. We recommend clinicians to maintain a high level of suspicion to consider the less common subtypes of primary hyperaldosteronism, especially given the fact that the management greatly varies.<\/jats:p>","DOI":"10.1136\/bcr-2016-216209","type":"journal-article","created":{"date-parts":[[2016,7,14]],"date-time":"2016-07-14T10:51:33Z","timestamp":1468493493000},"page":"bcr2016216209","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Primary hyperaldosteronism: a case of unilateral adrenal hyperplasia with contralateral incidentaloma"],"prefix":"10.1136","volume":"2016","author":[{"given":"Sujit","family":"Vakkalanka","sequence":"first","affiliation":[{"name":"University at Buffalo, Buffalo, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Zhao","sequence":"additional","affiliation":[{"name":"University at Buffalo, Buffalo, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Samannodi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Buffalo, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2016,7,14]]},"reference":[{"key":"2025082703250215000_2016.jul14_1.bcr2016216209.1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.20452\/pamw.79","article-title":"Micha\u0142 Lity\u0144ski\u2014a forgotten author of the first description on primary hyperaldosteronism","volume":"117","author":"Kucharz","year":"2007","journal-title":"Pol Arch Med Wewn"},{"key":"2025082703250215000_2016.jul14_1.bcr2016216209.2","unstructured":"DeGroot L , Jameson J . Endocrinology. 4th edn. Philadelphia: W.B. Sanders, 2001."},{"key":"2025082703250215000_2016.jul14_1.bcr2016216209.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-595X(85)80085-2"},{"key":"2025082703250215000_2016.jul14_1.bcr2016216209.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)06102-9"},{"key":"2025082703250215000_2016.jul14_1.bcr2016216209.5","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(65)90122-1"},{"key":"2025082703250215000_2016.jul14_1.bcr2016216209.6","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.27.193"},{"issue":"2","key":"2025082703250215000_2016.jul14_1.bcr2016216209.7","doi-asserted-by":"crossref","first-page":"S182","DOI":"10.1097\/00004872-200406002-00629","article-title":"Increased diagnosis of primary aldosteronism, including surgically correctable forms, in centers from five continents","volume":"22","author":"Mulatero","year":"2004","journal-title":"J Hypertens"},{"key":"2025082703250215000_2016.jul14_1.bcr2016216209.8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2007.02775.x"},{"key":"2025082703250215000_2016.jul14_1.bcr2016216209.9","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-90-3-386"},{"key":"2025082703250215000_2016.jul14_1.bcr2016216209.10","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-51-5-1190"},{"key":"2025082703250215000_2016.jul14_1.bcr2016216209.11","first-page":"1635","article-title":"Unilateral hypersecretion of aldosterone associated with adrenal hyperplasia as a cause of primary aldosteronism","volume":"5","author":"Ganguly","year":"1983","journal-title":"Clin Exp Hypertens A"},{"key":"2025082703250215000_2016.jul14_1.bcr2016216209.12","first-page":"238","article-title":"A rare cause of primary hyperaldosteronism unilateral adrenal hyperplasia: case report","volume":"35","author":"Gul","year":"2014","journal-title":"Endocrine Abstracts"},{"key":"2025082703250215000_2016.jul14_1.bcr2016216209.13","first-page":"76","article-title":"A case of predominantly unilateral pseudoprimary hyperaldosteronism","volume":"49","author":"Mendlowitz","year":"1982","journal-title":"Mt Sinai J Med"},{"key":"2025082703250215000_2016.jul14_1.bcr2016216209.14","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.6.1.75"},{"key":"2025082703250215000_2016.jul14_1.bcr2016216209.15","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-198901000-00021"},{"key":"2025082703250215000_2016.jul14_1.bcr2016216209.16","doi-asserted-by":"publisher","DOI":"10.1159\/000282488"},{"key":"2025082703250215000_2016.jul14_1.bcr2016216209.17","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-199406000-00017"},{"key":"2025082703250215000_2016.jul14_1.bcr2016216209.18","doi-asserted-by":"publisher","DOI":"10.1007\/BF03347340"},{"key":"2025082703250215000_2016.jul14_1.bcr2016216209.19","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.47.443"},{"key":"2025082703250215000_2016.jul14_1.bcr2016216209.20","doi-asserted-by":"publisher","DOI":"10.4158\/EP.6.2.153"},{"key":"2025082703250215000_2016.jul14_1.bcr2016216209.21","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(01)02312-3"},{"key":"2025082703250215000_2016.jul14_1.bcr2016216209.22","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-58-5-783"},{"key":"2025082703250215000_2016.jul14_1.bcr2016216209.23","first-page":"150063","article-title":"Resistant hypertension with adrenal nodule: are we removing the right gland?","volume":"2015","author":"Das","year":"2015","journal-title":"Endocrinol Diabetes Metab Case Rep"},{"key":"2025082703250215000_2016.jul14_1.bcr2016216209.24","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0889-8529(18)30266-4","article-title":"Diagnosis of hyperaldosteronism","volume":"20","author":"Melby","year":"1991","journal-title":"Endocrinol Metab Clin North Am"},{"key":"2025082703250215000_2016.jul14_1.bcr2016216209.25","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-0104"},{"key":"2025082703250215000_2016.jul14_1.bcr2016216209.26","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.141.5.497"},{"key":"2025082703250215000_2016.jul14_1.bcr2016216209.27","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-022051"},{"key":"2025082703250215000_2016.jul14_1.bcr2016216209.28","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-151-5-200909010-00007"},{"key":"2025082703250215000_2016.jul14_1.bcr2016216209.29","doi-asserted-by":"publisher","DOI":"10.1148\/rg.25si055514"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2016-216209","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T10:25:11Z","timestamp":1756290311000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2016-216209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,14]]},"references-count":29,"alternative-id":["10.1136\/bcr-2016-216209"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2016-216209","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2016,7,14]]}}}