{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:30:21Z","timestamp":1759332621438,"version":"3.44.0"},"reference-count":8,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2016,8,29]]},"abstract":"<jats:p>We present a case of a patient who following chemotherapy developed semi-invasive pulmonary aspergillosis and an aspergilloma in a lung cavity previously formed by microwave ablation (MWA). A 55-year-old woman presented with cough and shortness of breath after finishing three cycles of chemotherapy for a metastatic nerve sheath tumour. She had been treated by MWA for pulmonary metastases 2\u2005years previously which resulted in a residual right apical lung cavity. Postchemotherapy imaging showed that this cavity had enlarged, developed a thicker wall and contained lobulated soft tissue with a crescent sign on coronal reformats. In addition, the patient's <jats:italic>Aspergillus<\/jats:italic>-specific IgG was markedly raised. Treatment with itraconazole improved the symptoms and reduced the cavity size and wall thickness. This case shows that persisting lung cavities after MWA are a potential site for semi-invasive aspergillosis and has implications for the timing of chemotherapy in patient with metastatic lung disease.<\/jats:p>","DOI":"10.1136\/bcr-2016-216438","type":"journal-article","created":{"date-parts":[[2016,9,13]],"date-time":"2016-09-13T11:57:33Z","timestamp":1473767853000},"page":"bcr2016216438","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Aspergillosis complicating a microwave ablation cavity"],"prefix":"10.1136","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8730-524X","authenticated-orcid":false,"given":"Saurabh","family":"Singh","sequence":"first","affiliation":[{"name":"Interventional Oncology Service, University College London Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Bandula","sequence":"additional","affiliation":[{"name":"Interventional Oncology Service, University College London Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy","family":"Brown","sequence":"additional","affiliation":[{"name":"Respiratory Division of Medicine, University College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy","family":"Whelan","sequence":"additional","affiliation":[{"name":"The London Sarcoma Service, University College London Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rowland","family":"Illing","sequence":"additional","affiliation":[{"name":"Interventional Oncology Service, University College London Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2016,9,13]]},"reference":[{"key":"2025082704114759000_2016.sep13_4.bcr2016216438.1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20140598"},{"key":"2025082704114759000_2016.sep13_4.bcr2016216438.2","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-200309000-00012"},{"key":"2025082704114759000_2016.sep13_4.bcr2016216438.3","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2014-206291"},{"key":"2025082704114759000_2016.sep13_4.bcr2016216438.4","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.185.2.01850466"},{"key":"2025082704114759000_2016.sep13_4.bcr2016216438.5","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1342957"},{"key":"2025082704114759000_2016.sep13_4.bcr2016216438.6","doi-asserted-by":"publisher","DOI":"10.3109\/02656736.2014.955064"},{"key":"2025082704114759000_2016.sep13_4.bcr2016216438.7","doi-asserted-by":"publisher","DOI":"10.1148\/rg.324105181"},{"key":"2025082704114759000_2016.sep13_4.bcr2016216438.8","doi-asserted-by":"publisher","DOI":"10.1111\/crj.12105"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2016-216438","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T11:11:52Z","timestamp":1756293112000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2016-216438"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,13]]},"references-count":8,"alternative-id":["10.1136\/bcr-2016-216438"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2016-216438","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2016,9,13]]}}}