{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T12:40:45Z","timestamp":1756384845052,"version":"3.40.4"},"reference-count":27,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2016,8,12]]},"abstract":"<jats:p>We describe the case of a 73-year-old man who presented with a 10-month history of an ulcerating lesion on the glans penis. Initially this was thought to be an invasive squamous cell carcinoma but a biopsy showed histological features consistent with necrotizing granulomatous inflammation. Extensive serological, immunological and microbiological tests only showed a positive antinuclear and perinuclear antineutrophil cytoplasmic antibodies indicating a possible autoimmune aetiology but an underlying systemic cause was not identified. Treatment with oral corticosteroids limited the inflammatory process but due to the gross destruction of the glans penis, he still required a glansectomy and split-skin graft reconstruction from which he recovered well. Although this patient ultimately required surgery for this rare presentation, this case highlights the differential diagnosis of penile ulceration (that transcends neoplasia) and the importance of performing and interpreting penile biopsies before undertaking potentially mutilating definitive surgery.<\/jats:p>","DOI":"10.1136\/bcr-2016-216913","type":"journal-article","created":{"date-parts":[[2016,8,24]],"date-time":"2016-08-24T14:23:40Z","timestamp":1472048620000},"page":"bcr2016216913","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Necrotizing granulomatous inflammation of the glans penis"],"prefix":"10.1136","volume":"2016","author":[{"given":"Michelle","family":"Christodoulidou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher B","family":"Bunker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgia","family":"Trevisan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asif","family":"Muneer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2016,8,24]]},"reference":[{"key":"2025042703553812000_2016.aug24_1.bcr2016216913.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.currproblcancer.2015.03.010"},{"key":"2025042703553812000_2016.aug24_1.bcr2016216913.2","doi-asserted-by":"crossref","unstructured":"Bunker CB , Porter WM . Dermatoses of the male genitalia. In: Griffiths C , Barker J , Bleiker T , et al , eds. Rook's textbook of dermatology. 9th edn. Oxford: Wiley-Blackwell, 2016:111.1\u201341.","DOI":"10.1002\/9781118441213.rtd0112"},{"key":"2025042703553812000_2016.aug24_1.bcr2016216913.3","first-page":"725","article-title":"Secondary syphilis with exclusive peno-scrotal localization","volume":"144","author":"Dinotta","year":"2009","journal-title":"G Ital Dermatol Venereol"},{"key":"2025042703553812000_2016.aug24_1.bcr2016216913.4","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1668"},{"key":"2025042703553812000_2016.aug24_1.bcr2016216913.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.07.041"},{"key":"2025042703553812000_2016.aug24_1.bcr2016216913.6","doi-asserted-by":"publisher","DOI":"10.1590\/S0365-05962011000400021"},{"key":"2025042703553812000_2016.aug24_1.bcr2016216913.7","doi-asserted-by":"crossref","first-page":"601624","DOI":"10.1155\/2015\/601624","article-title":"Tuberculosis of the penis: a review of the literature","volume":"2015","author":"Venyo","year":"2015","journal-title":"Scientifica"},{"key":"2025042703553812000_2016.aug24_1.bcr2016216913.8","first-page":"317","article-title":"Primary involvement of penile skin in lepromatous leprosy","volume":"77","author":"Mukhopadhyay","year":"2005","journal-title":"Indian J Lepr"},{"key":"2025042703553812000_2016.aug24_1.bcr2016216913.9","first-page":"81","article-title":"Penile augmentation with resultant foreign material granuloma and sequalae","volume":"19","author":"Inn","year":"2012","journal-title":"Malays J Med Sci"},{"key":"2025042703553812000_2016.aug24_1.bcr2016216913.10","first-page":"689","article-title":"Penis swelling due to foreign body reaction after injection of silicone","volume":"8","author":"Plaza","year":"2010","journal-title":"J Dtsch Dermatol Ges"},{"key":"2025042703553812000_2016.aug24_1.bcr2016216913.11","unstructured":"Ormerod AD , Hampton PJ . Pyoderma gangrenosum. In: Griffiths C , Barker J , Bleiker T , et al , eds. Rook's textbook of dermatology. 9th edn. Oxford: Wiley-Blackwell, 2016:49.1\u20136."},{"key":"2025042703553812000_2016.aug24_1.bcr2016216913.12","first-page":"448","article-title":"Glands necrosis caused by necrotizing granulomatous arteritis","volume":"55","author":"Congregado","year":"2002","journal-title":"Arch Esp Urol"},{"issue":"(4 Suppl 1)","key":"2025042703553812000_2016.aug24_1.bcr2016216913.13","first-page":"AB142","article-title":"Wegener granulomatosis of the penis","volume":"68","author":"Iwasaki","year":"2013","journal-title":"J Am Acad Dermatol"},{"key":"2025042703553812000_2016.aug24_1.bcr2016216913.14","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02087.x"},{"key":"2025042703553812000_2016.aug24_1.bcr2016216913.15","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2000.00721.x"},{"key":"2025042703553812000_2016.aug24_1.bcr2016216913.16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1465-5101.2003.04400.x"},{"key":"2025042703553812000_2016.aug24_1.bcr2016216913.17","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.141.9.1175"},{"key":"2025042703553812000_2016.aug24_1.bcr2016216913.18","first-page":"2426","article-title":"Superficial granulomatous pyoderma gangrenosum of the penis: a case report","volume":"7","author":"Gopi","year":"2007","journal-title":"Scientific World J"},{"key":"2025042703553812000_2016.aug24_1.bcr2016216913.19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2008.03949.x"},{"key":"2025042703553812000_2016.aug24_1.bcr2016216913.20","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2009.24.6.1200"},{"key":"2025042703553812000_2016.aug24_1.bcr2016216913.21","first-page":"840","article-title":"Pyoderma gangrenosum masquerading as Donovanosis","volume":"40","author":"Pai","year":"2013","journal-title":"J Dermatol"},{"key":"2025042703553812000_2016.aug24_1.bcr2016216913.22","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1111\/1346-8138.12252","article-title":"Genital pyoderma gangrenosum: report of two cases and published work review of Japanese cases","volume":"40","author":"Satoh","year":"2013","journal-title":"J Dermatol"},{"key":"2025042703553812000_2016.aug24_1.bcr2016216913.23","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2012.06.023"},{"key":"2025042703553812000_2016.aug24_1.bcr2016216913.24","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1111\/j.1464-410X.1986.tb05913.x","article-title":"Plasma cell balanitis of Zoon","volume":"58","author":"Murray","year":"1996","journal-title":"Br J Urol"},{"key":"2025042703553812000_2016.aug24_1.bcr2016216913.25","first-page":"74","article-title":"Study on various types of infections related to balanitis in circumcised or uncircumcised male and its causes, symptoms and management","volume":"6","author":"Rajiah","year":"2012","journal-title":"Afr J Pharm Pharmacol"},{"key":"2025042703553812000_2016.aug24_1.bcr2016216913.26","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.152501"},{"key":"2025042703553812000_2016.aug24_1.bcr2016216913.27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2010.09463.x"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2016-216913","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T10:55:47Z","timestamp":1745751347000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2016-216913"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,24]]},"references-count":27,"alternative-id":["10.1136\/bcr-2016-216913"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2016-216913","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2016,8,24]]}}}