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Chest CT scan showed consolidations in the irradiation field and diffuse ground-glass attenuations in the non-irradiation regions. We suspected sequential CRT-induced DAH because of increased haemosiderin-laden macrophages in bronchoalveolar lavage fluid. Her clinical conditions did not improve with high-dose CS therapy. Therefore, rhTM was added, and her disease and serum high-mobility group box-1 levels improved rapidly. Therefore, rhTM plus CS might be a safe and effective treatment for sequential CRT-induced lung injury, although further study is necessary to validate these findings.<\/jats:p>","DOI":"10.1136\/bcr-2016-217183","type":"journal-article","created":{"date-parts":[[2016,10,28]],"date-time":"2016-10-28T11:12:55Z","timestamp":1477653175000},"page":"bcr2016217183","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Sequential adjuvant chemoradiotherapy-induced diffuse alveolar haemorrhage in a patient with breast cancer successfully treated with corticosteroid plus recombinant human soluble thrombomodulin"],"prefix":"10.1136","volume":"2016","author":[{"given":"Takamasa","family":"Kitajima","sequence":"first","affiliation":[{"name":"Tazuke Kofukai Foundation, Medical Research Institute, Kitano Hospital, Respiratory Disease Center, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Marumo","sequence":"additional","affiliation":[{"name":"Tazuke Kofukai Foundation, Medical Research Institute, Kitano Hospital, Respiratory Disease Center, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yurina","family":"Maeshima","sequence":"additional","affiliation":[{"name":"Tazuke Kofukai Foundation, Medical Research Institute, Kitano Hospital, Breast Center, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motonari","family":"Fukui","sequence":"additional","affiliation":[{"name":"Tazuke Kofukai Foundation, Medical Research Institute, Kitano Hospital, Respiratory Disease Center, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2016,10,28]]},"reference":[{"key":"2025082707215044000_2016.oct28_3.bcr2016217183.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67887-7"},{"key":"2025082707215044000_2016.oct28_3.bcr2016217183.2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(91)90782-Y"},{"key":"2025082707215044000_2016.oct28_3.bcr2016217183.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2005.07.015"},{"key":"2025082707215044000_2016.oct28_3.bcr2016217183.4","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(94)00429-O"},{"key":"2025082707215044000_2016.oct28_3.bcr2016217183.5","doi-asserted-by":"publisher","DOI":"10.1378\/chest.14-2746"},{"key":"2025082707215044000_2016.oct28_3.bcr2016217183.6","doi-asserted-by":"publisher","DOI":"10.1159\/000369828"},{"key":"2025082707215044000_2016.oct28_3.bcr2016217183.7","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19950915)76:6<1069::AID-CNCR2820760623>3.0.CO;2-7"},{"key":"2025082707215044000_2016.oct28_3.bcr2016217183.8","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1979.03300260022020"},{"key":"2025082707215044000_2016.oct28_3.bcr2016217183.9","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(94)00477-3"},{"key":"2025082707215044000_2016.oct28_3.bcr2016217183.10","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-0851"},{"key":"2025082707215044000_2016.oct28_3.bcr2016217183.11","first-page":"33","article-title":"[Drug-induced pneumonitis]","volume":"74","author":"Kondo","year":"1999","journal-title":"Kekkaku"},{"key":"2025082707215044000_2016.oct28_3.bcr2016217183.12","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.151.1.7812547"},{"key":"2025082707215044000_2016.oct28_3.bcr2016217183.13","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19860515)57:10<1941::AID-CNCR2820571009>3.0.CO;2-9"},{"key":"2025082707215044000_2016.oct28_3.bcr2016217183.14","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00119108"},{"key":"2025082707215044000_2016.oct28_3.bcr2016217183.15","doi-asserted-by":"crossref","unstructured":"Marumo S , Shirata M , Sakuramoto M , et al . 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