{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:36:24Z","timestamp":1778546184473,"version":"3.51.4"},"reference-count":14,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2016,10,29]]},"abstract":"<jats:p>A 44-year-old Hispanic woman presented to the emergency room with a 2-day history of sudden onset of severe cramping left lower quadrant abdominal pain associated with \u223c20 episodes diarrhoea. Abdominal CT scan exhibited bowel wall oedema and acute extensive colitis. On the basis of the preliminary diagnosis of acute abdomen, the patient was admitted under the surgical team and treated for acute colitis. Since her family history was significant for hereditary angioedema (HAE), complement studies were performed which revealed low complement C4 levels and abnormally low values of C1q esterase inhibitor. Thus, the diagnosis of HAE type I was established. This case report summarises that the symptoms of HAE are often non-specific, hence making the underlying cause difficult to diagnose.<\/jats:p>","DOI":"10.1136\/bcr-2016-217196","type":"journal-article","created":{"date-parts":[[2016,11,14]],"date-time":"2016-11-14T12:15:51Z","timestamp":1479125751000},"page":"bcr2016217196","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Hereditary angioedema (HAE): a cause for recurrent abdominal pain"],"prefix":"10.1136","volume":"2016","author":[{"given":"Parita","family":"Soni","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Maimonides Medical Center, Brooklyn, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivek","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Maimonides Medical Center, Brooklyn, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samson","family":"Alliu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Maimonides Medical Center, Brooklyn, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijay","family":"Shetty","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Maimonides Medical Center, Brooklyn, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2016,11,14]]},"reference":[{"key":"2025082804360650000_2016.nov14_1.bcr2016217196.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2005.09.064"},{"key":"2025082804360650000_2016.nov14_1.bcr2016217196.2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199207000-00003"},{"key":"2025082804360650000_2016.nov14_1.bcr2016217196.3","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1542\/peds.37.6.1017","article-title":"Hereditary angioneurotic edema: a clinical survey","volume":"37","author":"Donaldson","year":"1966","journal-title":"Pediatrics"},{"key":"2025082804360650000_2016.nov14_1.bcr2016217196.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2006.09.005"},{"key":"2025082804360650000_2016.nov14_1.bcr2016217196.5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp0803977"},{"key":"2025082804360650000_2016.nov14_1.bcr2016217196.6","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60581-9"},{"key":"2025082804360650000_2016.nov14_1.bcr2016217196.7","unstructured":"FDA approves ecallantide for hereditary angioedema. Medscape. http:\/\/www.fda.gov\/NewsEvents\/Newsroom\/PressAnnouncements\/ucm192687.htm (accessed 30 May 2016)."},{"key":"2025082804360650000_2016.nov14_1.bcr2016217196.8","unstructured":"FDA approves Shire's FIRAZYR (icatibant injection) for acute attacks of hereditary angioedema (HAE). Shire. http:\/\/www.fda.gov\/NewsEvents\/Newsroom\/PressAnnouncements\/ucm269616.htm (accessed 30 May 2016)."},{"key":"2025082804360650000_2016.nov14_1.bcr2016217196.9","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/0016-5085(87)90576-2","article-title":"Recurrent abdominal pain as the sole manifestation of hereditary angioedema in multiple family members","volume":"93","author":"Weinstock","year":"1987","journal-title":"Gastroenterology"},{"key":"2025082804360650000_2016.nov14_1.bcr2016217196.10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198305053081802"},{"issue":"1","key":"2025082804360650000_2016.nov14_1.bcr2016217196.11","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/0091-6749(86)90231-9","article-title":"Acquired C1 esterase-inhibitor deficiency: case report with emphasis on complement and kallikrein activation during two patterns of clinical manifestations","volume":"78","author":"Hentges","year":"1986","journal-title":"J Allergy Clin Immunol"},{"key":"2025082804360650000_2016.nov14_1.bcr2016217196.12","doi-asserted-by":"publisher","DOI":"10.1016\/S0171-2985(98)80042-9"},{"key":"2025082804360650000_2016.nov14_1.bcr2016217196.13","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1097\/00004836-199304000-00016","article-title":"Hereditary angioneurotic edema with severe hypovolemic shock","volume":"16","author":"Cohen","year":"1993","journal-title":"J Clin Gastroenterol"},{"key":"2025082804360650000_2016.nov14_1.bcr2016217196.14","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/1471-230X-13-123","article-title":"Leukocytosis and high hematocrit levels during abdominal attacks of hereditary angioedema","volume":"13","author":"Ohsawa","year":"2013","journal-title":"BMC Gastroenterol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2016-217196","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T11:36:13Z","timestamp":1756380973000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2016-217196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,14]]},"references-count":14,"alternative-id":["10.1136\/bcr-2016-217196"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2016-217196","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,14]]}}}