{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T18:30:34Z","timestamp":1783189834932,"version":"3.54.6"},"reference-count":8,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2016,10,5]]},"abstract":"<jats:p>A 24-year-old male patient with acute lymphoblastic leukaemia (ALL), in complete remission, presented with the symptoms of gradual onset painless diminution of vision in the right eye (OD) of 2-month duration. On examination, best-corrected visual acuity in OD was finger-counting at 1\u2005m and near vision was less than N<jats:sub>36<\/jats:sub>. Anterior segment examination was normal, except for the presence of relative afferent pupillary defect in OD. Fundus examination showed optic disc oedema, peripapillary and vitreous haemorrhage, dilated and tortuous veins over the disc and presence of subretinal infiltrates and subretinal fluid around the optic disc. Clinical picture was suggestive of leukaemic infiltration of the optic nerve head. Cytological analysis of the cerebrospinal fluid did not show any abnormal cells or blasts .Vitreous biopsy from OD was suggestive of leukaemic infiltration. After radiotherapy, the leukaemic infiltrates regressed and visual acuity improved to 6\/6, N<jats:sub>6<\/jats:sub>in OD.<\/jats:p>","DOI":"10.1136\/bcr-2016-217239","type":"journal-article","created":{"date-parts":[[2016,10,19]],"date-time":"2016-10-19T15:53:37Z","timestamp":1476892417000},"page":"bcr2016217239","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":20,"title":["Leukaemic infiltration of the optic nerve head: a rare site of initial relapse"],"prefix":"10.1136","volume":"2016","author":[{"given":"Shailaja Bhat","family":"Shenoy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thoiba","family":"Karam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karthik","family":"Udupa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhavna","family":"Nayal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2016,10,19]]},"reference":[{"key":"2025042705322203000_2016.oct19_2.bcr2016217239.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(83)80013-X"},{"key":"2025042705322203000_2016.oct19_2.bcr2016217239.2","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1001\/archopht.1961.00960010492010","article-title":"Ocular involvement in leukaemia and allied disorders","volume":"66","author":"Allen","year":"1961","journal-title":"Arch Ophthalmol"},{"key":"2025042705322203000_2016.oct19_2.bcr2016217239.3","first-page":"137","article-title":"Leukemic involvement of the optic nerve","volume":"55","author":"Rosenthal","year":"1974","journal-title":"Trans Pacific Coast Oto Ophthalmol Soc Annual meet"},{"key":"2025042705322203000_2016.oct19_2.bcr2016217239.4","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(88)90013-X"},{"key":"2025042705322203000_2016.oct19_2.bcr2016217239.5","doi-asserted-by":"crossref","first-page":"pii:bcr1120103517","DOI":"10.1136\/bcr.11.2010.3517","article-title":"Optic nerve involvement as a first manifestation of acute lymphoblastic leukaemia after remission","volume":"2011","author":"Peyman","year":"2011","journal-title":"BMJ Case Rep"},{"key":"2025042705322203000_2016.oct19_2.bcr2016217239.6","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6700701"},{"key":"2025042705322203000_2016.oct19_2.bcr2016217239.7","first-page":"97","article-title":"Unilateral optic nerve leukemic infiltration with sudden vision loss heralding a systemic relapse of acute lymphoblastic leukaemia","volume":"25","author":"Lin","year":"2005","journal-title":"J Med Sci"},{"key":"2025042705322203000_2016.oct19_2.bcr2016217239.8","first-page":"153","article-title":"Unilateral optic nerve infiltration as an initial site of relapse of acute lymphoblastic leukaemia in remission Oman","volume":"3","author":"Bandopadhyaya","year":"2010","journal-title":"J Ophthalmol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2016-217239","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T12:32:26Z","timestamp":1745757146000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2016-217239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,19]]},"references-count":8,"alternative-id":["10.1136\/bcr-2016-217239"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2016-217239","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,19]]}}}