{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T04:54:42Z","timestamp":1768625682771,"version":"3.49.0"},"reference-count":9,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2016,10,12]]},"abstract":"<jats:p>We examined an immediate, but short-lived, response to crizotinib, a drug with a new indication for <jats:italic>ROS1<\/jats:italic> rearranged non-small cell lung cancer (NSCLC) in a middle-aged non-smoker. The patient presented with metastatic NSCLC and extensive disease in multiple organs. He was treated with crizotinib 250\u2005mg twice a day. Within 2\u20133\u2005days, his condition rapidly improved, which was evident in a CT scan 2\u2005months later. However, after 3\u2005months of treatment, his condition deteriorated dramatically. The patient did not respond to ceritinib, a second-line drug that targets anaplastic lymphoma kinase, and died shortly after. This case demonstrated an impressive but brief response to crizotinib.<\/jats:p>","DOI":"10.1136\/bcr-2016-217322","type":"journal-article","created":{"date-parts":[[2016,10,26]],"date-time":"2016-10-26T11:28:52Z","timestamp":1477481332000},"page":"bcr2016217322","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Crizotinib in <i>ROS1<\/i> rearranged non-small cell lung cancer (NSCLC), from response to resistance"],"prefix":"10.1136","volume":"2016","author":[{"given":"Eric","family":"Zhong","sequence":"first","affiliation":[{"name":"Quality Medical Oncology, Flushing, New York, USA"},{"name":"Brown University, Providence, Rhode Island, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Huang","sequence":"additional","affiliation":[{"name":"Quality Medical Oncology, Flushing, New York, USA"},{"name":"New York Presbyterian Queens, Flushing, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2016,10,26]]},"reference":[{"key":"2025082703552520000_2016.oct26_1.bcr2016217322.1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2012-0311"},{"key":"2025082703552520000_2016.oct26_1.bcr2016217322.2","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2016-0101"},{"key":"2025082703552520000_2016.oct26_1.bcr2016217322.3","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.58.3302"},{"key":"2025082703552520000_2016.oct26_1.bcr2016217322.4","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-0550"},{"key":"2025082703552520000_2016.oct26_1.bcr2016217322.5","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21262"},{"key":"2025082703552520000_2016.oct26_1.bcr2016217322.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2014.02.007"},{"key":"2025082703552520000_2016.oct26_1.bcr2016217322.7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1406766"},{"key":"2025082703552520000_2016.oct26_1.bcr2016217322.8","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-1350"},{"key":"2025082703552520000_2016.oct26_1.bcr2016217322.9","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-6-489"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2016-217322","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T10:55:34Z","timestamp":1756292134000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2016-217322"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,26]]},"references-count":9,"alternative-id":["10.1136\/bcr-2016-217322"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2016-217322","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,26]]}}}