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This case highlights the life-threatening and limb-threatening thrombosis secondary to a rare inherited thrombophilia on exposure to extreme high altitude.<\/jats:p>","DOI":"10.1136\/bcr-2016-217361","type":"journal-article","created":{"date-parts":[[2016,11,23]],"date-time":"2016-11-23T11:51:07Z","timestamp":1479901867000},"page":"bcr2016217361","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["PAI-1 polymorphism as a cause of severe high altitude associated arteriovenous thrombosis"],"prefix":"10.1136","volume":"2016","author":[{"given":"Velu","family":"Nair","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uday","family":"Yanamandra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rai","family":"Kumud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanjakya","family":"Ghosh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2016,11,23]]},"reference":[{"key":"2025042705505131000_2016.nov23_1.bcr2016217361.1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1301413"},{"key":"2025042705505131000_2016.nov23_1.bcr2016217361.2","doi-asserted-by":"publisher","DOI":"10.1159\/000126200"},{"key":"2025042705505131000_2016.nov23_1.bcr2016217361.3","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2000.02321.x"},{"key":"2025042705505131000_2016.nov23_1.bcr2016217361.4","doi-asserted-by":"publisher","DOI":"10.1177\/107602960300900405"},{"key":"2025042705505131000_2016.nov23_1.bcr2016217361.5","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1055\/s-0037-1615105","article-title":"The 4G\/5G sequence polymorphism in the promoter of plasminogen activator inhibitor-1 (PAI-1) gene: relationship to plasma PAI-1 level in venous thromboembolism","volume":"79","author":"Stegnar","year":"1998","journal-title":"Thromb Haemost"},{"key":"2025042705505131000_2016.nov23_1.bcr2016217361.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(96)00211-3"},{"key":"2025042705505131000_2016.nov23_1.bcr2016217361.7","first-page":"266","article-title":"Relationship between gene polymorphism of the PAI-1 promoter and myocardial infarction","volume":"114","author":"Fu","year":"2001","journal-title":"Chin Med J (Engl)"},{"key":"2025042705505131000_2016.nov23_1.bcr2016217361.8","doi-asserted-by":"publisher","DOI":"10.1159\/000128045"},{"key":"2025042705505131000_2016.nov23_1.bcr2016217361.9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2005.03723.x"},{"key":"2025042705505131000_2016.nov23_1.bcr2016217361.10","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1055\/s-0037-1612997","article-title":"Short-term exposure to high altitude causes coagulation activation and inhibits fibrinolysis","volume":"87","author":"Mannucci","year":"2002","journal-title":"Thromb Haemost"},{"key":"2025042705505131000_2016.nov23_1.bcr2016217361.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2006.09.013"},{"key":"2025042705505131000_2016.nov23_1.bcr2016217361.12","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-05-501924"},{"key":"2025042705505131000_2016.nov23_1.bcr2016217361.13","first-page":"71","article-title":"Cerebral thrombosis at altitude: its pathogenesis and the problems of prevention and treatment","volume":"57","author":"Song","year":"1986","journal-title":"Aviat Space Environ Med"},{"key":"2025042705505131000_2016.nov23_1.bcr2016217361.14","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.0590041520.x"},{"key":"2025042705505131000_2016.nov23_1.bcr2016217361.15","doi-asserted-by":"publisher","DOI":"10.1053\/meta.2000.6749"},{"key":"2025042705505131000_2016.nov23_1.bcr2016217361.16","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000098004.26252.EB"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2016-217361","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T12:50:58Z","timestamp":1745758258000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2016-217361"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,23]]},"references-count":16,"alternative-id":["10.1136\/bcr-2016-217361"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2016-217361","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,23]]}}}