{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T21:28:29Z","timestamp":1774387709088,"version":"3.50.1"},"reference-count":12,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2016,10,23]]},"abstract":"<jats:p>Clomiphene citrate is widely used by the female population for the management of a wide array of medical conditions especially those related to ovulation, but its use in male population remains controversial. Efficacy of clomiphene is not well established in male hypogonadism and infertility. Its side effects and complications are also poorly studied or reported. We present a case of a man with infertility issues for which he started receiving clomiphene citrate 3\u2005weeks before presenting with progressive symptoms of headache, vomiting, transient blurred vision and diplopia, which eventually turned out to be the symptoms of intracranial venous thrombosis. After excluding the common causes of intracranial venous thrombosis and hypercoagulable state, clomiphene citrate seems the most likely culprit.<\/jats:p>","DOI":"10.1136\/bcr-2016-217403","type":"journal-article","created":{"date-parts":[[2016,11,10]],"date-time":"2016-11-10T10:17:31Z","timestamp":1478773051000},"page":"bcr2016217403","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Intracranial venous thrombosis in a man taking clomiphene citrate"],"prefix":"10.1136","volume":"2016","author":[{"given":"M","family":"Zahid","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Arshad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Zafar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Al-Mohannadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2016,11,10]]},"reference":[{"key":"2025042705443580000_2016.nov10_1.bcr2016217403.1","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0b013e31820a8364"},{"key":"2025042705443580000_2016.nov10_1.bcr2016217403.2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000117571.76197.26"},{"key":"2025042705443580000_2016.nov10_1.bcr2016217403.3","first-page":"439","article-title":"Cerebral venous thrombosis: when etiology makes the difference","volume":"24","author":"Alonso-C\u00e1novas","year":"2009","journal-title":"Neurologia"},{"key":"2025042705443580000_2016.nov10_1.bcr2016217403.4","doi-asserted-by":"publisher","DOI":"10.1136\/pmj.76.891.12"},{"key":"2025042705443580000_2016.nov10_1.bcr2016217403.5","doi-asserted-by":"crossref","unstructured":"Hughes E , Brown J , Collins JJ , et al . Clomiphene citrate for unexplained subfertility in women. Cochrane Database Syst Rev 2010;(1):CD000057. doi:10.1002\/14651858.CD000057.pub2","DOI":"10.1002\/14651858.CD000057.pub2"},{"key":"2025042705443580000_2016.nov10_1.bcr2016217403.6","doi-asserted-by":"publisher","DOI":"10.1177\/1933719112466304"},{"key":"2025042705443580000_2016.nov10_1.bcr2016217403.7","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1055\/s-0033-1345271","article-title":"Clomiphene citrate in the management of male infertility","volume":"31","author":"Roth","year":"2013","journal-title":"Semin Reprod Med"},{"key":"2025042705443580000_2016.nov10_1.bcr2016217403.8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2005.00075.x"},{"key":"2025042705443580000_2016.nov10_1.bcr2016217403.9","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1159\/000319497","article-title":"Association between clomiphene citrate and visual disturbances with special emphasis on central retinal vein occlusion: a review","volume":"71","author":"Viola","year":"2011","journal-title":"Gynecol Obstet Invest"},{"key":"2025042705443580000_2016.nov10_1.bcr2016217403.10","first-page":"2011","article-title":"Central retinal vein occlusion associated with clomiphene-induced ovulation","volume":"90","author":"Lee","year":"2008","journal-title":"Fertil Steril"},{"key":"2025042705443580000_2016.nov10_1.bcr2016217403.11","doi-asserted-by":"publisher","DOI":"10.1016\/0301-2115(95)02193-B"},{"key":"2025042705443580000_2016.nov10_1.bcr2016217403.12","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1089\/gtmb.2008.0104","article-title":"Central retinal vein occlusion secondary to clomiphene treatment in a male carrier of factor V Leiden","volume":"13","author":"Politou","year":"2009","journal-title":"Genet Test Mol Biomarkers"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2016-217403","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T12:44:46Z","timestamp":1745757886000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2016-217403"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,10]]},"references-count":12,"alternative-id":["10.1136\/bcr-2016-217403"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2016-217403","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,10]]}}}