{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T15:47:38Z","timestamp":1759938458285,"version":"3.44.0"},"reference-count":29,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2016,12,21]]},"abstract":"<jats:p>The use of high-dose baclofen emerged in 2008 in the treatment of alcohol-use disorders. Its prescription is still off-label in France, but recent trials have suggested the interest of using high doses for alcohol dependence, so we have to deal with an increase in its use. However, we still have few data about the adverse effects of a high-dose baclofen prescription, especially in complex addictive disorders. We present a case of a 32-year-old man who sought treatment for gambling disorders (GDs). He had complex addictive disorders, including alcohol-use disorders and GDs. He developed a severe GD, after treatment with a high dose of baclofen. The maximum dose was 160\u2005mg\/day, prescribed for his alcohol-use disorders. According to the Naranjo algorithm, the score was +7, it enabled to conclude that problem of gambling was probably imputable to baclofen. We discuss this case with reference to literature.<\/jats:p>","DOI":"10.1136\/bcr-2016-217506","type":"journal-article","created":{"date-parts":[[2017,1,10]],"date-time":"2017-01-10T10:19:32Z","timestamp":1484043572000},"page":"bcr2016217506","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Gambling disorder: a side effect of an off-label prescription of baclofen\u2014literature review"],"prefix":"10.1136","volume":"2017","author":[{"given":"Morgane","family":"Guillou-Landreat","sequence":"first","affiliation":[{"name":"ERCR SPURBO, Department of Addictive Disorders, Universit\u00e9 de Bretagne Occidentale, Brest, France"},{"name":"Addictology Department, Brest University Hospital, Brest, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Victorri Vigneau","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology, CHU Nantes, Nantes, Pays de la Loire, France"},{"name":"EA 4275 \u201cBiostatistics, Pharmacoepidemiology and Subjective Measures in Health Sciences,\u201d Nantes University, Nantes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Gerardin","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology, CHU Nantes, Nantes, Pays de la Loire, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2017,1,10]]},"reference":[{"key":"2025082804404485000_2017.jan10_2.bcr2016217506.1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1977.00500190056008"},{"key":"2025082804404485000_2017.jan10_2.bcr2016217506.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61814-5"},{"key":"2025082804404485000_2017.jan10_2.bcr2016217506.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2013.09.008"},{"key":"2025082804404485000_2017.jan10_2.bcr2016217506.4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2011.03752.x"},{"key":"2025082804404485000_2017.jan10_2.bcr2016217506.5","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/j.euroneuro.2015.04.002","article-title":"High-dose baclofen for the treatment of alcohol dependence (BACLAD study): a randomized, placebo-controlled trial","volume":"25","author":"M\u00fcller","year":"2015","journal-title":"Eur Neuropsychopharmacol"},{"key":"2025082804404485000_2017.jan10_2.bcr2016217506.6","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1016\/j.euroneuro.2015.05.008","article-title":"Baclofen for alcohol dependence: relationships between baclofen and alcohol dosing and the occurrence of major sedation","volume":"10","author":"Rolland","year":"2015","journal-title":"Eur Neuropsychopharmacol"},{"key":"2025082804404485000_2017.jan10_2.bcr2016217506.7","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1111\/bcpt.12344","article-title":"A nationwide register-based survey of baclofen toxicity","volume":"116","author":"Kiel","year":"2015","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"2025082804404485000_2017.jan10_2.bcr2016217506.8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-6723.2006.00805.x"},{"key":"2025082804404485000_2017.jan10_2.bcr2016217506.9","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/ags076"},{"key":"2025082804404485000_2017.jan10_2.bcr2016217506.10","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1007\/s10899-015-9545-y","article-title":"Towards a validation of the three pathways model of pathological gambling","volume":"32","author":"Valleur","year":"2016","journal-title":"J Gambl Stud"},{"key":"2025082804404485000_2017.jan10_2.bcr2016217506.11","doi-asserted-by":"crossref","unstructured":"American Psychiatric A. 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