{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:24:25Z","timestamp":1790753065899,"version":"4.1.0"},"reference-count":8,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2017,2,7]]},"abstract":"<jats:p>Preterm ovarian hyperstimulation syndrome is a rare syndrome in which preterm infant girls have hypogastric, upper leg and labial swelling accompanied by elevated serum oestradiol levels and ovarian follicular cysts on ultrasound. Our case is an infant born at 23\u2005weeks gestational age who at 30\u2005weeks postconceptional age (PCA) developed elevated 17-hydroxyprogesterone on her newborn screen with associated clitoromegaly and a ventral groove on the inferior aspect of the erectile tissue. An initial pelvic ultrasound at 32\u2005weeks PCA demonstrated a normal appearing uterus, but the ovaries were not visualised. At 39\u2005weeks PCA, follicular ovarian cysts were noted bilaterally (31\u00d726\u00d721\u2005mm on left and 38\u00d725\u00d736\u2005mm on right). Without treatment, oestradiol and testosterone levels began normalising by 42\u2005weeks PCA. After this point, the right ovarian cysts had resolved and the left ovarian cyst continued to diminish in size.<\/jats:p>","DOI":"10.1136\/bcr-2016-217517","type":"journal-article","created":{"date-parts":[[2017,2,22]],"date-time":"2017-02-22T11:15:42Z","timestamp":1487762142000},"page":"bcr2016217517","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Atypical case of preterm ovarian hyperstimulation syndrome"],"prefix":"10.1136","volume":"2017","author":[{"given":"Michelle A","family":"Durst","sequence":"first","affiliation":[{"name":"University of Manitoba, Department of Paediatrics and Child Health, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandy","family":"Wicklow","sequence":"additional","affiliation":[{"name":"University of Manitoba, Department of Paediatrics and Child Health, Section of Paediatric Endocrinology, Winnipeg, Manitoba, Canada"},{"name":"Children's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Narvey","sequence":"additional","affiliation":[{"name":"Children's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada"},{"name":"University of Manitoba, Department of Paediatrics and Child Health, Section of Neonatology, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2017,2,22]]},"reference":[{"key":"2025082805252590000_2017.feb22_1.bcr2016217517.1","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1111\/j.1365-2265.1976.tb01985.x","article-title":"Hypothalamic-pituitary-gonadal relationships in man from birth to puberty","volume":"5","author":"Forest","year":"1976","journal-title":"Clin Endocrinol (Oxf)"},{"key":"2025082805252590000_2017.feb22_1.bcr2016217517.2","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1203\/00006450-198506000-00009","article-title":"Ovarian hyperstimulation syndrome in preterm infants","volume":"19","author":"Sedin","year":"1985","journal-title":"Pediatr Res"},{"key":"2025082805252590000_2017.feb22_1.bcr2016217517.3","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1016\/S1701-2163(16)35085-X","article-title":"The diagnosis and management of ovarian hyperstimulation syndrome","volume":"33","author":"Shmorgun","year":"2011","journal-title":"J Obstet Gynaecol Can"},{"key":"2025082805252590000_2017.feb22_1.bcr2016217517.4","doi-asserted-by":"publisher","DOI":"10.1159\/000173743"},{"key":"2025082805252590000_2017.feb22_1.bcr2016217517.5","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1515\/jpem-2013-0452","article-title":"Ovarian hyperstimulation syndrome treated by medroxyprogesterone acetate","volume":"27","author":"Halis","year":"2014","journal-title":"J Pediatr Endocrinol Metab"},{"key":"2025082805252590000_2017.feb22_1.bcr2016217517.6","doi-asserted-by":"crossref","first-page":"186","DOI":"10.5152\/tpa.2014.2038","article-title":"Mini puberty and its interpretation","volume":"49","author":"Kurto\u011flu","year":"2014","journal-title":"Turk Pediatri Ars"},{"key":"2025082805252590000_2017.feb22_1.bcr2016217517.7","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1515\/jpem-2013-0166","article-title":"Preterm ovarian hyperstimulation syndrome presented with vaginal bleeding: a case report","volume":"27","author":"Altuntas","year":"2014","journal-title":"J Pediatr Endocrinol Metab"},{"key":"2025082805252590000_2017.feb22_1.bcr2016217517.8","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1056\/NEJMicm1402955","article-title":"Preterm ovarian hyperstimulation","volume":"372","author":"Esen","year":"2015","journal-title":"N Engl J Med"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2016-217517","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T12:25:33Z","timestamp":1756383933000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2016-217517"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,22]]},"references-count":8,"alternative-id":["10.1136\/bcr-2016-217517"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2016-217517","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,22]]}}}