{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T13:09:44Z","timestamp":1758632984102,"version":"3.40.4"},"reference-count":21,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2016,11,23]]},"abstract":"<jats:p>Neurofibromatosis type-1 (NF1) is a multisystem disorder with very rare descriptions of hip instability. We report a case of a 37-year-old man with known NF1 and childhood-onset of left foot drop, who developed persistent left hip pain following a minor trauma. Physical examination revealed left-sided mild foot drop, hip abductor weakness, bilateral sensory loss in feet and an antalgic gait. Work-up revealed anterolateral subluxation of the left femoral head along with left hip plexiform neurofibroma (PN), dysplastic and degenerative changes, neurofibromatous neuropathy and chronic left L5 radiculopathy. Initial improvement after surgical resection of the PN was unsustained and followed by increasing pain and recurrent hip subluxation, prompting a total hip arthroplasty which resulted in marked improvement of symptoms. Our patient, unlike those in other reports, illustrates multiple aetiologies of hip dislocation in NF1 including local factors, lumbar radiculopathy and polyneuropathy, reinforcing the importance of a multidisciplinary approach in the management of such cases.<\/jats:p>","DOI":"10.1136\/bcr-2016-217971","type":"journal-article","created":{"date-parts":[[2016,12,8]],"date-time":"2016-12-08T15:28:53Z","timestamp":1481210933000},"page":"bcr2016217971","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Multifactorial pathological hip subluxation in neurofibromatosis type-1 (NF1) due to intra-articular plexiform neurofibroma, lumbar radiculopathy and neurofibromatous polyneuropathy"],"prefix":"10.1136","volume":"2016","author":[{"given":"Waqar","family":"Waheed","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego F","family":"Diego F Lemos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nelms","family":"Nathaniel Nelms","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rup","family":"Tandan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2016,12,8]]},"reference":[{"key":"2025042705575338000_2016.dec08_1.bcr2016217971.1","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/356713a0","article-title":"Aberrant regulation of Ras proteins in malignant tumor cells from type 1 neurofibromatosis patients","volume":"56","author":"Basu","year":"1992","journal-title":"Nature"},{"key":"2025042705575338000_2016.dec08_1.bcr2016217971.2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1988.00520290115023"},{"key":"2025042705575338000_2016.dec08_1.bcr2016217971.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2011.04.008"},{"key":"2025042705575338000_2016.dec08_1.bcr2016217971.4","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181bd1326"},{"key":"2025042705575338000_2016.dec08_1.bcr2016217971.5","first-page":"1007","article-title":"Spontaneous hip dislocation secondary to intra-articular neurofibroma: a case report","volume":"3","author":"Kumar","year":"2014","journal-title":"Skeletal Radiol"},{"key":"2025042705575338000_2016.dec08_1.bcr2016217971.6","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s12306-007-0027-y","article-title":"Pathological dislocation of the hip in neurofibromatosis: a case report","volume":"91","author":"Lampasi","year":"2008","journal-title":"Chir Organi Mov"},{"key":"2025042705575338000_2016.dec08_1.bcr2016217971.7","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1097\/01241398-199409000-00023","article-title":"Pathologic dislocation of the hip in von Recklinghausen's disease: a report of two cases","volume":"674","author":"Haga","year":"1994","journal-title":"J Pediatr Orthop"},{"key":"2025042705575338000_2016.dec08_1.bcr2016217971.8","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1097\/01.rct.0000228157.04023.48","article-title":"Intraarticular neurofibroma of the hip","volume":"30","author":"Aguiar","year":"2006","journal-title":"J Comput Assist Tomogr"},{"key":"2025042705575338000_2016.dec08_1.bcr2016217971.9","first-page":"172","article-title":"Surgical treatment of lumbosacral pseudarthrosis and spondyloptosis in a patient with neurofibromatosis type 1 and a large lumbar anterior meningocele. 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