{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T12:37:25Z","timestamp":1763642245520,"version":"3.44.0"},"reference-count":8,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2017,6,7]]},"abstract":"<jats:p>Neonatal alloimmune thrombocytopaenia (NAIT) generally results from platelet opsonisation by maternal antibodies against fetal platelet antigens inherited from the infant\u2019s father. Newborn monochorionic twins presented with petechial haemorrhages at 10 hours of life, along with severe thrombocytopaenia. Despite the initial treatment with platelet transfusions and intravenous immunoglobulin, they both had persistent thrombocytopaenia during their first 45 days of life. Class I human leucocyte antigen (HLA) antibodies with broad specificity against several HLA-B antigens were detected in the maternal serum. Weak antibodies against HLA-B57 and HLA-B58 in sera from both twins supported NAIT as the most likely diagnosis. Platelet transfusion requirements of the twins lasted for 7 weeks. Transfusion of HLA-matched platelet concentrates was more efficacious to manage thrombocytopaenia compared with platelet concentrates from random donors. Platelet genotyping and determination of HLA antibody specificity are needed to select compatible platelet units to expedite safe recovery from thrombocytopaenia in NAIT.<\/jats:p>","DOI":"10.1136\/bcr-2016-218269","type":"journal-article","created":{"date-parts":[[2017,7,5]],"date-time":"2017-07-05T05:58:18Z","timestamp":1499234298000},"page":"bcr-2016-218269","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Neonatal alloimmune thrombocytopaenia associated with maternal HLA antibodies"],"prefix":"10.1136","volume":"2017","author":[{"given":"Kristina","family":"Wendel","sequence":"first","affiliation":[{"name":"Department of Paediatrics, Oslo Universitetssykehus, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c7i\u011fdem Akalin","family":"Akk\u00f6k","sequence":"additional","affiliation":[{"name":"Department of Immunology and Transfusion Medicine, Oslo Universitetssykehus, Oslo, Norway"},{"name":"University and Regional Laboratories, Department of Clinical Immunology and Transfusion Medicine, Lund University, Lund, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Kutzsche","sequence":"additional","affiliation":[{"name":"Centre for Education, International Medical University, Kuala Lumpur, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2017,7,5]]},"reference":[{"key":"2025082804534197000_2017.jul04_1.bcr-2016-218269.1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13639"},{"key":"2025082804534197000_2017.jul04_1.bcr-2016-218269.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2015.12.004"},{"key":"2025082804534197000_2017.jul04_1.bcr-2016-218269.3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1996.tb02542.x"},{"key":"2025082804534197000_2017.jul04_1.bcr-2016-218269.4","doi-asserted-by":"crossref","DOI":"10.1182\/blood.V126.23.4647.4647","article-title":"Anti-HLA antibodies in neonatal alloimmune thrombocytopenia \u2013 Is there any clinical significance?","volume":"126","author":"Bonstein","year":"2015","journal-title":"Blood"},{"key":"2025082804534197000_2017.jul04_1.bcr-2016-218269.5","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-1-39"},{"key":"2025082804534197000_2017.jul04_1.bcr-2016-218269.6","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.siny.2015.11.001","article-title":"Thrombocytopenia and platelet transfusion in the neonate","volume":"21","author":"Cremer","year":"2016","journal-title":"Semin Fetal Neonatal Med"},{"key":"2025082804534197000_2017.jul04_1.bcr-2016-218269.7","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e318186d87b"},{"key":"2025082804534197000_2017.jul04_1.bcr-2016-218269.8","doi-asserted-by":"publisher","DOI":"10.1007\/BF00320268"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2016-218269","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T11:53:47Z","timestamp":1756382027000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2016-218269"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,5]]},"references-count":8,"alternative-id":["10.1136\/bcr-2016-218269"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2016-218269","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2017,7,5]]}}}