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Clinical, laboratory and histopathological findings indicated the development of secondary haemophagocytic lymphohistiocytosis triggered by these closely succeeding viral primary infections.<\/jats:p>","DOI":"10.1136\/bcr-2016-218310","type":"journal-article","created":{"date-parts":[[2017,3,29]],"date-time":"2017-03-29T12:11:13Z","timestamp":1490789473000},"page":"bcr2016218310","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Haemophagocytic lymphohistiocytosis associated with fulminant hepatitis and multiorgan failure following primary Epstein\u2013Barr virus and herpes simplex virus type 1 infection"],"prefix":"10.1136","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3051-2686","authenticated-orcid":false,"given":"Claudia","family":"Honsig","sequence":"first","affiliation":[{"name":"Division of Clinical Virology, Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Beinhardt","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josef","family":"Tomasits","sequence":"additional","affiliation":[{"name":"Kepler Universityclinic, Med Campus III, Linz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans Peter","family":"Dienes","sequence":"additional","affiliation":[{"name":"Medical University of Vienna, Institute of Clinical Pathology, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2017,3,29]]},"reference":[{"key":"2025082700574731000_2017.mar29_1.bcr2016218310.1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.2147\/JBM.S46255","article-title":"Hemophagocytic lymphohistiocytosis: review of etiologies and management","volume":"5","author":"George","year":"2014","journal-title":"J Blood Med"},{"key":"2025082700574731000_2017.mar29_1.bcr2016218310.2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-03-278127"},{"key":"2025082700574731000_2017.mar29_1.bcr2016218310.3","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1002\/jmv.24359","article-title":"Viral etiology, clinical and laboratory features of adult hemophagocytic lymphohistiocytosis","volume":"88","author":"Chen","year":"2016","journal-title":"J Med Virol"},{"key":"2025082700574731000_2017.mar29_1.bcr2016218310.4","first-page":"491567","article-title":"Epstein-Barr virus-related hemophagocytic lymphohistiocytosis: hematologic emergency in the critical care setting","volume":"2015","author":"Hashemi-Sadraei","year":"2015","journal-title":"Case Rep Hematol"},{"key":"2025082700574731000_2017.mar29_1.bcr2016218310.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2004.06.004"},{"key":"2025082700574731000_2017.mar29_1.bcr2016218310.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2009.02.050"},{"key":"2025082700574731000_2017.mar29_1.bcr2016218310.7","doi-asserted-by":"crossref","first-page":"463825","DOI":"10.1155\/2015\/463825","article-title":"Disseminated herpes simplex virus with fulminant hepatitis","volume":"2015","author":"Rimawi","year":"2015","journal-title":"Case Reports Hepatol"},{"key":"2025082700574731000_2017.mar29_1.bcr2016218310.8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2009.01108.x"},{"key":"2025082700574731000_2017.mar29_1.bcr2016218310.9","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/24.3.334"},{"key":"2025082700574731000_2017.mar29_1.bcr2016218310.10","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e318236e02d"},{"key":"2025082700574731000_2017.mar29_1.bcr2016218310.11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.00806.x"},{"key":"2025082700574731000_2017.mar29_1.bcr2016218310.12","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.jcv.2015.04.013","article-title":"Hemophagocytic lymphohistiocytosis due to acute primary herpes simplex virus 1 infection","volume":"68","author":"Drori","year":"2015","journal-title":"J Clin Virol"},{"key":"2025082700574731000_2017.mar29_1.bcr2016218310.13","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61048-X"},{"key":"2025082700574731000_2017.mar29_1.bcr2016218310.14","doi-asserted-by":"crossref","unstructured":"Pinto-Patarroyo GP , Rytting ME , Vierling JM , et al . 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