{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T10:26:39Z","timestamp":1756895199415,"version":"3.40.4"},"reference-count":18,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2017,1,5]]},"abstract":"<jats:p>Bone fractures are not uncommon in paediatric age. However, when recurrent, an underlying clinical condition must not be excluded. We describe the case of a boy aged 7 years, referred for investigation of recurrent bone fractures. Personal and family histories were unremarkable. Physical examination was normal. Almost all primary bone disorders were excluded. Additional laboratory investigations ruled out the majority of secondary causes of bone fragility. Coeliac disease (CD) serologies, however, were positive, and duodenal biopsies confirmed this diagnosis (Marsh III B). On a gluten-free diet, he suffered no more fractures and the bone mineral density improved. CD was also confirmed in his asymptomatic older brother. It is essential to diagnose CD as early as possible in order to minimise the compromise in bone health and prevent other complications of the disease. First-degree relatives should always be screened for the disease, even asymptomatic ones.<\/jats:p>","DOI":"10.1136\/bcr-2016-218477","type":"journal-article","created":{"date-parts":[[2017,1,20]],"date-time":"2017-01-20T16:24:21Z","timestamp":1484929461000},"page":"bcr2016218477","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Child with multiple fractures: a rare presentation of a common disease"],"prefix":"10.1136","volume":"2017","author":[{"given":"Filipa","family":"Dias Costa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Maia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2017,1,20]]},"reference":[{"key":"2025042702304696000_2017.jan20_1.bcr2016218477.1","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1159\/000381047","article-title":"A practical approach to children with recurrent fractures","volume":"28","author":"Korula","year":"2015","journal-title":"Endocr Dev"},{"key":"2025042702304696000_2017.jan20_1.bcr2016218477.2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-2546"},{"key":"2025042702304696000_2017.jan20_1.bcr2016218477.3","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-2079"},{"key":"2025042702304696000_2017.jan20_1.bcr2016218477.4","first-page":"113","article-title":"Osteoporosis: integrating biomarkers and other diagnostic correlates into the management of bone fragility","volume":"12","author":"McCormick","year":"2007","journal-title":"Altern Med Rev"},{"key":"2025042702304696000_2017.jan20_1.bcr2016218477.5","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31821a23d0"},{"key":"2025042702304696000_2017.jan20_1.bcr2016218477.6","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-3164"},{"key":"2025042702304696000_2017.jan20_1.bcr2016218477.7","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31814c3d79"},{"key":"2025042702304696000_2017.jan20_1.bcr2016218477.8","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-3147"},{"key":"2025042702304696000_2017.jan20_1.bcr2016218477.9","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200411000-00011"},{"key":"2025042702304696000_2017.jan20_1.bcr2016218477.10","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1602323"},{"key":"2025042702304696000_2017.jan20_1.bcr2016218477.11","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31819ca18e"},{"key":"2025042702304696000_2017.jan20_1.bcr2016218477.12","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2009.50.5.617"},{"key":"2025042702304696000_2017.jan20_1.bcr2016218477.13","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v17.i25.3035"},{"key":"2025042702304696000_2017.jan20_1.bcr2016218477.14","first-page":"242","article-title":"Celiac disease presenting as severe osteopenia","volume":"70","author":"Mulder","year":"2011","journal-title":"Hawaii Med J"},{"key":"2025042702304696000_2017.jan20_1.bcr2016218477.15","doi-asserted-by":"crossref","first-page":"780","DOI":"10.4103\/2230-8210.100674","article-title":"Celiac disease: a missed cause of metabolic bone disease","volume":"16","author":"Rastogi","year":"2012","journal-title":"Indian J Endocrinol Metab"},{"key":"2025042702304696000_2017.jan20_1.bcr2016218477.16","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-1858"},{"key":"2025042702304696000_2017.jan20_1.bcr2016218477.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2013.05.027"},{"key":"2025042702304696000_2017.jan20_1.bcr2016218477.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2014.01.004"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2016-218477","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T09:30:55Z","timestamp":1745746255000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2016-218477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,20]]},"references-count":18,"alternative-id":["10.1136\/bcr-2016-218477"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2016-218477","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2017,1,20]]}}}