{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T12:40:02Z","timestamp":1745757602975,"version":"3.40.4"},"reference-count":16,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2017,2,1]]},"abstract":"<jats:p>We report a case of severe<jats:italic>Plasmodium knowlesi<\/jats:italic>and dengue coinfection in a previously healthy 59-year-old Malay man who presented with worsening shortness of breath, high-grade fever with chills and rigors, dry cough, myalgia, arthralgia, chest discomfort and poor appetite of 1\u2005week duration. There was a history mosquito fogging around his neighbourhood in his hometown. Further history revealed that he went to a forest in Jeli (northern part of Kelantan) 3\u2005weeks prior to the event. Initially he was treated as severe dengue with plasma leakage complicated with type 1 respiratory failure as evidenced by positive serum NS1-antigen and thrombocytopenia. Blood for malarial parasite (BFMP) was sent for test as there was suspicion of malaria due to persistent thrombocytopenia despite recovering from dengue infection and the presence of a risk factor. The test revealed high count of malaria parasite. Confirmatory PCR identified the parasite to be<jats:italic>Plasmodium knowlesi<\/jats:italic>. Intravenous artesunate was administered to the patient immediately after acquiring the BFMP result. Severe malaria was complicated with acute kidney injury and septicaemic shock. Fortunately the patient made full recovery and was discharged from the ward after 2\u2005weeks of hospitalisation.<\/jats:p>","DOI":"10.1136\/bcr-2016-218480","type":"journal-article","created":{"date-parts":[[2017,2,20]],"date-time":"2017-02-20T15:00:17Z","timestamp":1487602817000},"page":"bcr2016218480","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Severe<i>Plasmodium knowlesi<\/i>with dengue coinfection"],"prefix":"10.1136","volume":"2017","author":[{"given":"Mohd Jazman","family":"Che Rahim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2178-6121","authenticated-orcid":false,"given":"Nurashikin","family":"Mohammad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alwi Muhd","family":"Besari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wan Syamimee","family":"Wan Ghazali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2017,2,20]]},"reference":[{"key":"2025042705264258000_2017.feb20_1.bcr2016218480.1","doi-asserted-by":"publisher","DOI":"10.1086\/524889"},{"key":"2025042705264258000_2017.feb20_1.bcr2016218480.2","doi-asserted-by":"publisher","DOI":"10.1086\/524888"},{"key":"2025042705264258000_2017.feb20_1.bcr2016218480.3","first-page":"19","article-title":"Management of Plasmodium knowlesi malaria without PCR confirmation","volume":"41","author":"Wilairatana","year":"2010","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"2025042705264258000_2017.feb20_1.bcr2016218480.4","doi-asserted-by":"publisher","DOI":"10.1086\/605439"},{"key":"2025042705264258000_2017.feb20_1.bcr2016218480.5","unstructured":"Guidelines for the treatment of malaria. WHO, 2015."},{"key":"2025042705264258000_2017.feb20_1.bcr2016218480.6","unstructured":"Management of dengue infection in adults, 3rd edn. Ministry of Health Malaysia, 2015."},{"key":"2025042705264258000_2017.feb20_1.bcr2016218480.7","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-13-463"},{"key":"2025042705264258000_2017.feb20_1.bcr2016218480.8","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-12-425"},{"key":"2025042705264258000_2017.feb20_1.bcr2016218480.9","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(15)00415-6"},{"key":"2025042705264258000_2017.feb20_1.bcr2016218480.10","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/S2221-1691(11)60053-1","article-title":"Concurrent malaria and dengue infection: a brief summary and comment","volume":"1","author":"Wiwanitkit","year":"2011","journal-title":"Asian Pac J Trop Biomed"},{"key":"2025042705264258000_2017.feb20_1.bcr2016218480.11","doi-asserted-by":"crossref","first-page":"00043","DOI":"10.15406\/mojph.2015.02.00043","article-title":"Chikungunya outbreaks from 2000 to 2015: a review","volume":"2","author":"Diop","year":"2015","journal-title":"MOJ Public Health"},{"key":"2025042705264258000_2017.feb20_1.bcr2016218480.12","first-page":"68","article-title":"Zika virus and its potential re-emergence in Malaysia","volume":"71","author":"Sam","year":"2016","journal-title":"Med J Malaysia"},{"key":"2025042705264258000_2017.feb20_1.bcr2016218480.13","unstructured":"http:\/\/www.who.int\/denguecontrol\/arbo-viral\/other_arboviral_chikungunya\/en\/"},{"key":"2025042705264258000_2017.feb20_1.bcr2016218480.14","unstructured":"http:\/\/www.who.int\/mediacentre\/factsheets\/zika\/en\/"},{"key":"2025042705264258000_2017.feb20_1.bcr2016218480.15","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1056\/NEJMc1610613","article-title":"Fatal Zika virus infection with secondary nonsexual transmission","volume":"375","author":"Swaminathan","year":"2016","journal-title":"N Engl J Med"},{"key":"2025042705264258000_2017.feb20_1.bcr2016218480.16","first-page":"398","article-title":"Case series of naturally acquired Plasmodium knowlesi infection in a tertiary teaching hospital","volume":"29","author":"Azira","year":"2012","journal-title":"Trop Biomed"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2016-218480","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T12:26:48Z","timestamp":1745756808000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2016-218480"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,20]]},"references-count":16,"alternative-id":["10.1136\/bcr-2016-218480"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2016-218480","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2017,2,20]]}}}