{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T11:52:49Z","timestamp":1771674769200,"version":"3.50.1"},"reference-count":7,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2017,1,12]]},"abstract":"<jats:p>Treatment of pyoderma gangrenosum (PG) remains a challenge, and there are currently no specific or uniformly effective therapies. Although widespread or rapidly progressive disease often requires systemic treatment, localised and mild lesions may be effectively controlled with topical agents. The most frequently applied topical drugs are corticosteroids and calcineurin inhibitors. Recently, a patient with idiopathic PG of the lower limb was successfully treated with topical timolol and collagenase. Here, we report a case of a patient with collagenous colitis, ankylosing spondylitis and periumbilical PG. Persistent ulcerated skin lesions were successfully treated with topical timolol, although a flare of the underlying bowel disease temporarily interrupted the improvement. The case presented enhances the previously reported therapeutic potential of topical timolol in the treatment of PG. Control of chronic underlying disorders is critical to prevent rebound flares and maintain the benefit.<\/jats:p>","DOI":"10.1136\/bcr-2016-218589","type":"journal-article","created":{"date-parts":[[2017,1,27]],"date-time":"2017-01-27T09:30:49Z","timestamp":1485509449000},"page":"bcr2016218589","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Topical timolol for the treatment of pyoderma gangrenosum"],"prefix":"10.1136","volume":"2017","author":[{"given":"Catarina","family":"Moreira","sequence":"first","affiliation":[{"name":"Centro Hospitalar S\u00e3o Jo\u00e3o, Porto, Portugal"},{"name":"Faculty of Medicine, University of Porto, Porto, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofia","family":"Lopes","sequence":"additional","affiliation":[{"name":"Centro Hospitalar S\u00e3o Jo\u00e3o, Porto, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Jo\u00e3o","family":"Cruz","sequence":"additional","affiliation":[{"name":"Centro Hospitalar S\u00e3o Jo\u00e3o, Porto, Portugal"},{"name":"Faculty of Medicine, University of Porto, Porto, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filomena","family":"Azevedo","sequence":"additional","affiliation":[{"name":"Centro Hospitalar S\u00e3o Jo\u00e3o, Porto, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2017,1,27]]},"reference":[{"key":"2025082700273378000_2017.jan27_1.bcr2016218589.1","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.jaad.2014.07.060","article-title":"Collagenase ointment and topical timolol gel for treating idiopathic pyoderma gangrenosum","volume":"7","author":"Liu","year":"2014","journal-title":"J Am Acad Dermatol"},{"key":"2025082700273378000_2017.jan27_1.bcr2016218589.2","doi-asserted-by":"crossref","first-page":"285","DOI":"10.2147\/CCID.S61202","article-title":"Pyoderma gangrenosum: challenges and solutions","volume":"8","author":"Gameiro","year":"2015","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"2025082700273378000_2017.jan27_1.bcr2016218589.3","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.jaad.2016.06.016","article-title":"Clinical outcomes and response of patients applying topical therapy for pyoderma gangrenosum: a prospective cohort study","volume":"75","author":"Thomas","year":"2016","journal-title":"J Am Acad Dermatol"},{"key":"2025082700273378000_2017.jan27_1.bcr2016218589.4","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/pde.12767","article-title":"Topical timolol for infantile hemangiomas: evidence for efficacy and degree of systemic absorption","volume":"33","author":"Weibel","year":"2016","journal-title":"Pediatr Dermatol"},{"key":"2025082700273378000_2017.jan27_1.bcr2016218589.5","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.jaad.2013.06.003","article-title":"Successful treatment of a chronic venous leg ulcer using a topical beta-blocker","volume":"69","author":"Lev-Tov","year":"2013","journal-title":"J Am Acad Dermatol"},{"key":"2025082700273378000_2017.jan27_1.bcr2016218589.6","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1001\/jamadermatol.2013.7135","article-title":"Topical timolol for recalcitrant wounds","volume":"149","author":"Braun","year":"2013","journal-title":"JAMA Dermatol"},{"key":"2025082700273378000_2017.jan27_1.bcr2016218589.7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2011.02200.x"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2016-218589","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T07:27:42Z","timestamp":1756279662000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2016-218589"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,27]]},"references-count":7,"alternative-id":["10.1136\/bcr-2016-218589"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2016-218589","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,27]]}}}