{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T10:34:14Z","timestamp":1782902054130,"version":"3.54.5"},"reference-count":12,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2017,10,20]]},"abstract":"<jats:p>\n                    A 72-year-old man presented to the hospital with exacerbation of congestive heart failure. He was given furosemide 40\u2009mg intravenously twice at 4\u2009hours apart. At 4\u2009hours after the second dose of furosemide, his white blood cells (WBC) dropped acutely from 9.8 to 2.4\u00d710\n                    <jats:sup>9<\/jats:sup>\n                    \/L (reference range 4.1 to 9.3\u00d710\n                    <jats:sup>9<\/jats:sup>\n                    \/L). With the discontinuation of furosemide, the WBC trended up to 7.1\u00d710\n                    <jats:sup>9<\/jats:sup>\n                    \/L about 13\u2009hours after the second dose of intravenous furosemide and remained in normal range for the next 3 days. However, when the oral furosemide was started on hospital day 4, there was a mild drop in WBC count, which returned to and maintained at baseline since the next day. The dynamic changes in the patient\u2019s WBC were coincident with the use of furosemide. The possible mechanisms of furosemide-associated transient hyperacute leucopenia were discussed.\n                  <\/jats:p>","DOI":"10.1136\/bcr-2016-218776","type":"journal-article","created":{"date-parts":[[2017,11,22]],"date-time":"2017-11-22T00:55:11Z","timestamp":1511312111000},"page":"bcr-2016-218776","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Hyperacute leucopenia associated with furosemide"],"prefix":"10.1136","volume":"2017","author":[{"given":"Ben-Jiang","family":"Ma","sequence":"first","affiliation":[{"name":"IPC Healthcare\/TeamHealth, Lake Mary, Florida, USA"},{"name":"Florida Neurology, Lake Mary, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2017,11,21]]},"reference":[{"key":"2025082707304334000_2017.nov20_1.bcr-2016-218776.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1005419"},{"key":"2025082707304334000_2017.nov20_1.bcr-2016-218776.2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00119.2002"},{"key":"2025082707304334000_2017.nov20_1.bcr-2016-218776.3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199808063390607"},{"key":"2025082707304334000_2017.nov20_1.bcr-2016-218776.4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022963"},{"key":"2025082707304334000_2017.nov20_1.bcr-2016-218776.5","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1E350"},{"key":"2025082707304334000_2017.nov20_1.bcr-2016-218776.6","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/S0140-6736(01)06443-1","article-title":"Potentiators and bolus intravenous furosemide","volume":"358","author":"Cook","year":"2001","journal-title":"Lancet"},{"key":"2025082707304334000_2017.nov20_1.bcr-2016-218776.7","doi-asserted-by":"crossref","first-page":"17","DOI":"10.5049\/EBP.2015.13.1.17","article-title":"Loop diuretics in clinical practice","volume":"13","author":"Oh","year":"2015","journal-title":"Electrolyte Blood Press"},{"key":"2025082707304334000_2017.nov20_1.bcr-2016-218776.8","first-page":"43","article-title":"Case report: furosemide and pancreatitis: Importance of dose and latency period before reaction","volume":"59","author":"Chao","year":"2013","journal-title":"Can Fam Physician"},{"key":"2025082707304334000_2017.nov20_1.bcr-2016-218776.9","first-page":"21","article-title":"Thrombocytopenia due to sulfonamide cross-sensitivity","volume":"81","author":"Bretza","year":"1982","journal-title":"Wis Med J"},{"key":"2025082707304334000_2017.nov20_1.bcr-2016-218776.10","doi-asserted-by":"publisher","DOI":"10.1592\/phco.24.9.856.36106"},{"key":"2025082707304334000_2017.nov20_1.bcr-2016-218776.11","first-page":"1434","article-title":"Approach to managing patients with sulfa allergy: use of antibiotic and nonantibiotic sulfonamides","volume":"52","author":"Ponka","year":"2006","journal-title":"Can Fam Physician"},{"key":"2025082707304334000_2017.nov20_1.bcr-2016-218776.12","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1G314"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2016-218776","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T14:30:52Z","timestamp":1756305052000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2016-218776"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,21]]},"references-count":12,"alternative-id":["10.1136\/bcr-2016-218776"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2016-218776","relation":{"is-referenced-by":[{"id-type":"doi","id":"10.1186\/s12887-026-06698-6","asserted-by":"object"}]},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,21]]}}}