{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T17:30:48Z","timestamp":1787679048026,"version":"build-2784847793"},"reference-count":31,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2017,1,26]]},"abstract":"<jats:p>\n                    <jats:italic>Cryptococcus neoformans<\/jats:italic>\n                    and\n                    <jats:italic>C. gattii<\/jats:italic>\n                    cause invasive fungal disease, with meningitis being the most common manifestation of central nervous system (CNS) disease. Encapsulated cryptococcomas occur rarely, predominantly in immunocompetent hosts, usually related to\n                    <jats:italic>C. gattii<\/jats:italic>\n                    . Our patient was an immunocompetent man who presented with headache and a large cystic CNS lesion thought to be glioblastoma. Biopsy of a concomitant lung lesion confirmed cryptococcoma and empiric antifungal therapy was started for presumed CNS cryptococcoma. Antifungal therapy failed to shrink the CNS lesion, and surgical excision confirmed\n                    <jats:italic>C. gattii<\/jats:italic>\n                    CNS cryptococcoma. Following surgery he had complete resolution of symptoms. This case highlights that cryptococcoma cannot be distinguished from tumour on clinical or imaging findings. A combined medical and surgical approach is optimal for the management of large or surgically accessible cryptococcomas, as antifungal therapy alone is unlikely to penetrate large lesions sufficiently to lead to a cure.\n                  <\/jats:p>","DOI":"10.1136\/bcr-2016-218824","type":"journal-article","created":{"date-parts":[[2017,2,10]],"date-time":"2017-02-10T10:55:20Z","timestamp":1486724120000},"page":"bcr2016218824","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":38,"title":["Cerebral cryptococcoma mimicking glioblastoma"],"prefix":"10.1136","volume":"2017","author":[{"given":"Kimberly B","family":"Ulett","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James W J","family":"Cockburn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalind","family":"Jeffree","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1094-9853","authenticated-orcid":false,"given":"Marion L","family":"Woods","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2017,2,10]]},"reference":[{"key":"2025042705235584000_2017.feb10_1.bcr2016218824.1","doi-asserted-by":"publisher","DOI":"10.1086\/313992"},{"key":"2025042705235584000_2017.feb10_1.bcr2016218824.2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/20.3.611"},{"key":"2025042705235584000_2017.feb10_1.bcr2016218824.3","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/21.1.28"},{"key":"2025042705235584000_2017.feb10_1.bcr2016218824.4","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1093\/oxfordjournals.aje.a113861","article-title":"Epidemiologic differences between the two varieties of Cryptococcus neoformans","volume":"120","author":"Kwon-Chung","year":"1984","journal-title":"Am J Epidemiol"},{"key":"2025042705235584000_2017.feb10_1.bcr2016218824.5","doi-asserted-by":"publisher","DOI":"10.3201\/eid1602.090900"},{"key":"2025042705235584000_2017.feb10_1.bcr2016218824.6","doi-asserted-by":"publisher","DOI":"10.3201\/eid1601.090369"},{"key":"2025042705235584000_2017.feb10_1.bcr2016218824.7","doi-asserted-by":"publisher","DOI":"10.1086\/649858"},{"key":"2025042705235584000_2017.feb10_1.bcr2016218824.8","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm264"},{"key":"2025042705235584000_2017.feb10_1.bcr2016218824.9","doi-asserted-by":"publisher","DOI":"10.1080\/mmy.39.2.155.168"},{"key":"2025042705235584000_2017.feb10_1.bcr2016218824.10","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/j.1875-9114.1998.tb03851.x","article-title":"The association between cryptococcal variety and immunocompetent and immunocompromised hosts","volume":"18","author":"Peachey","year":"1998","journal-title":"Pharmacotherapy"},{"key":"2025042705235584000_2017.feb10_1.bcr2016218824.11","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1128\/jcm.32.7.1680-1684.1994","article-title":"Comparison of commercial kits for detection of cryptococcal antigen","volume":"32","author":"Tanner","year":"1994","journal-title":"J Clin Microbiol"},{"key":"2025042705235584000_2017.feb10_1.bcr2016218824.12","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1136\/jnnp.s1-2.6.105","article-title":"Original papers: on Froin's syndrome, and its relation to allied conditions in the cerebrospinal fluid","volume":"2","author":"Greenfield","year":"1921","journal-title":"J Neurol Psychopathol"},{"key":"2025042705235584000_2017.feb10_1.bcr2016218824.13","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/50945216"},{"key":"2025042705235584000_2017.feb10_1.bcr2016218824.14","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1259\/bjr.74.877.740083","article-title":"Cerebral cryptococcosis: atypical appearances on CT","volume":"74","author":"Awasthi","year":"2001","journal-title":"Br J Radiol"},{"key":"2025042705235584000_2017.feb10_1.bcr2016218824.15","doi-asserted-by":"crossref","first-page":"603","DOI":"10.2214\/ajr.154.3.2106227","article-title":"CT of intracranial cryptococcosis","volume":"154","author":"Popovich","year":"1990","journal-title":"AJR Am J Roentgenol"},{"key":"2025042705235584000_2017.feb10_1.bcr2016218824.16","doi-asserted-by":"publisher","DOI":"10.1080\/02841850510021201"},{"key":"2025042705235584000_2017.feb10_1.bcr2016218824.17","doi-asserted-by":"publisher","DOI":"10.1179\/016164101101199397"},{"key":"2025042705235584000_2017.feb10_1.bcr2016218824.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.surneu.2004.04.020"},{"key":"2025042705235584000_2017.feb10_1.bcr2016218824.19","doi-asserted-by":"crossref","unstructured":"Perfect JR . 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