{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:32:05Z","timestamp":1763037125780,"version":"3.44.0"},"reference-count":35,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2017,10,5]]},"abstract":"<jats:p>Appendectomy is the most commonly performed surgical procedure, affecting 1%\u20138% of the paediatric population, with a total 7% lifetime risk, most likely in adolescents and young adults.<\/jats:p>\n               <jats:p>A case of familial aggregation was reported in our hospital in a family composed of nine siblings from which six of them (66.6%) had been treated of acute appendicitis, five of them in our centre.<\/jats:p>\n               <jats:p>Many factors have been described as predisposing to appendicitis. Several studies have highlighted the influence of genes in the evolution of this disease and its severity, demonstrating a relative risk increase by three when family history is present.<\/jats:p>\n               <jats:p>Family history of acute appendicitis is an important factor to be taken into consideration during the medical interview. Clinicians attempting to fine-tune their diagnostic accuracy when patients present with acute abdominal pain should inquire about family history of appendicitis.<\/jats:p>","DOI":"10.1136\/bcr-2016-218838","type":"journal-article","created":{"date-parts":[[2017,10,20]],"date-time":"2017-10-20T00:15:11Z","timestamp":1508458511000},"page":"bcr-2016-218838","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Familial history aggregation on acute appendicitis"],"prefix":"10.1136","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7101-327X","authenticated-orcid":false,"given":"Francesc","family":"Sim\u00f3 Alari","sequence":"first","affiliation":[{"name":"General surgery, Centre hospitalier du val d\u2019Ariege, Foix, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Israel","family":"Gutierrez","sequence":"additional","affiliation":[{"name":"General surgery, Centre hospitalier du val d\u2019Ariege, Foix, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judit","family":"Gimen\u00e9z P\u00e9rez","sequence":"additional","affiliation":[{"name":"General practitioner, Hospital Universitari MutuaTerrassa, Terrassa, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2017,10,19]]},"reference":[{"key":"2025082703170667000_2017.oct16_1.bcr-2016-218838.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00275-5"},{"key":"2025082703170667000_2017.oct16_1.bcr-2016-218838.2","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1177\/145749690709600405","article-title":"Heredity and familial tendency of acute appendicitis","volume":"96","author":"Ergul","year":"2007","journal-title":"Scand J Surg"},{"key":"2025082703170667000_2017.oct16_1.bcr-2016-218838.3","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.9329"},{"issue":"4 Pt 1","key":"2025082703170667000_2017.oct16_1.bcr-2016-218838.4","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1542\/peds.98.4.680","article-title":"Clinical outcomes of children with acute abdominal pain","volume":"98","author":"Scholer","year":"1996","journal-title":"Pediatrics"},{"key":"2025082703170667000_2017.oct16_1.bcr-2016-218838.5","doi-asserted-by":"publisher","DOI":"10.1097\/00006565-199206000-00003"},{"key":"2025082703170667000_2017.oct16_1.bcr-2016-218838.6","first-page":"107","article-title":"Perforating inflammation of the vermiform appendix","volume":"1","author":"Fitz","year":"1886","journal-title":"Trans Assoc Am Phys"},{"key":"2025082703170667000_2017.oct16_1.bcr-2016-218838.7","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s11605-009-1094-1","article-title":"Predictive factors for negative outcomes in initial non-operative management of suspected appendicitis","volume":"14","author":"Shindoh","year":"2010","journal-title":"J Gastrointest Surg"},{"key":"2025082703170667000_2017.oct16_1.bcr-2016-218838.8","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1080\/09637480050029647","article-title":"Fiber intake and childhood appendicitis","volume":"51","author":"Adamidis","year":"2000","journal-title":"Int J Food Sci Nutr"},{"key":"2025082703170667000_2017.oct16_1.bcr-2016-218838.9","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.6108.305"},{"key":"2025082703170667000_2017.oct16_1.bcr-2016-218838.10","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6103.1672"},{"key":"2025082703170667000_2017.oct16_1.bcr-2016-218838.11","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800580916"},{"key":"2025082703170667000_2017.oct16_1.bcr-2016-218838.12","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.jss.2012.06.034","article-title":"Monthly variation in acute appendicitis incidence: a 10-year nationwide population-based study","volume":"178","author":"Wei","year":"2012","journal-title":"J Surg Res"},{"key":"2025082703170667000_2017.oct16_1.bcr-2016-218838.13","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1097\/SLA.0000000000000780","article-title":"Risk of acute appendicitis in and around pregnancy: a population-based cohort study from England","volume":"261","author":"Zingone","year":"2015","journal-title":"Ann Surg"},{"key":"2025082703170667000_2017.oct16_1.bcr-2016-218838.14","doi-asserted-by":"publisher","DOI":"10.1001\/jama.298.4.438"},{"key":"2025082703170667000_2017.oct16_1.bcr-2016-218838.15","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s00247-006-0288-x","article-title":"Pathology of the appendix in children: an institutional experience and review of the literature","volume":"37","author":"Rabah","year":"2007","journal-title":"Pediatr Radiol"},{"key":"2025082703170667000_2017.oct16_1.bcr-2016-218838.16","unstructured":"Silen W . 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