{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,15]],"date-time":"2025-06-15T16:22:36Z","timestamp":1750004556996,"version":"3.40.4"},"reference-count":17,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2017,4,12]]},"abstract":"<jats:p>Haemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening syndrome characterised by defective cytotoxic function and hypercytokinaemia leading to macrophage expansion and haemophagocytosis. Patients often present with unexplained fevers, hepatosplenomegaly and pancytopenia, with elevation in serum ferritin and triglyceride. Acquired forms are triggered by infection, malignancy or rheumatological disorders. HLH in the setting of chronic lymphocytic leukaemia is rarely reported, however, and is usually associated with infection or as a consequence of chemotherapy. We present a case of HLH in a 64-year-old Caucasian woman with the only identified trigger being her hitherto untreated CLL.<\/jats:p>","DOI":"10.1136\/bcr-2016-219057","type":"journal-article","created":{"date-parts":[[2017,4,26]],"date-time":"2017-04-26T12:15:35Z","timestamp":1493208935000},"page":"bcr-2016-219057","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Haemophagocytic lymphohistiocytosis as a consequence of untreated B-cell chronic lymphocytic leukaemia"],"prefix":"10.1136","volume":"2017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1602-8396","authenticated-orcid":false,"given":"Chris","family":"Bailey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Dearden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirit","family":"Ardeshna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2017,4,26]]},"reference":[{"key":"2025042705580958000_2017.apr26_1.bcr-2016-219057.1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2013.1.605"},{"key":"2025042705580958000_2017.apr26_1.bcr-2016-219057.2","doi-asserted-by":"crossref","unstructured":"Filipovich AH . Hemophagocytic lymphohistiocytosis (HLH) and related disorders. Hematology Am Soc Hematol Educ Program 2009:127\u201331.doi:10.1182\/asheducation-2009.1.127","DOI":"10.1182\/asheducation-2009.1.127"},{"key":"2025042705580958000_2017.apr26_1.bcr-2016-219057.3","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-07-370148"},{"key":"2025042705580958000_2017.apr26_1.bcr-2016-219057.4","doi-asserted-by":"crossref","first-page":"69","DOI":"10.2147\/JBM.S46255","article-title":"Hemophagocytic lymphohistiocytosis: review of etiologies and management","volume":"5","author":"George","year":"2014","journal-title":"J Blood Med"},{"key":"2025042705580958000_2017.apr26_1.bcr-2016-219057.5","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/bjh.12822","article-title":"Haemophagocytic lymphohistiocytosis following fludarabine\/cyclophosphamide chemotherapy for chronic lymphocytic leukaemia","volume":"166","author":"Jayakody Arachchillage","year":"2014","journal-title":"Br J Haematol"},{"key":"2025042705580958000_2017.apr26_1.bcr-2016-219057.6","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(07)70290-6"},{"key":"2025042705580958000_2017.apr26_1.bcr-2016-219057.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2013.12.012"},{"key":"2025042705580958000_2017.apr26_1.bcr-2016-219057.8","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-01-551622"},{"key":"2025042705580958000_2017.apr26_1.bcr-2016-219057.9","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21039"},{"key":"2025042705580958000_2017.apr26_1.bcr-2016-219057.10","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.1002\/art.38690","article-title":"Development and validation of the HScore, a score for the diagnosis of reactive hemophagocytic syndrome","volume":"66","author":"Fardet","year":"2014","journal-title":"Arthritis Rheumatol"},{"key":"2025042705580958000_2017.apr26_1.bcr-2016-219057.11","first-page":"1104","article-title":"Methotrexate as a possible trigger of macrophage activation syndrome in systemic juvenile idiopathic arthritis","volume":"29","author":"Eraso","year":"2002","journal-title":"J Rheumatol"},{"key":"2025042705580958000_2017.apr26_1.bcr-2016-219057.12","doi-asserted-by":"crossref","first-page":"4616","DOI":"10.1182\/blood.V126.23.4616.4616","article-title":"Hemophagocytic lymphohistiocytosis in a patient with relapsed chronic lymphocytic leukemia treated with ibrutinib","volume":"126","author":"Ciccone","year":"2015","journal-title":"Blood"},{"key":"2025042705580958000_2017.apr26_1.bcr-2016-219057.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2011.03.009"},{"key":"2025042705580958000_2017.apr26_1.bcr-2016-219057.14","doi-asserted-by":"crossref","first-page":"734","DOI":"10.2169\/naika.103.734","article-title":"[Case report; Disseminated Mycobacterium abscessus infection with hemophagocytic syndrome during treatment of chronic lymphocytic leukemia]","volume":"103","author":"Katagiri","year":"2014","journal-title":"Nihon Naika Gakkai Zasshi"},{"key":"2025042705580958000_2017.apr26_1.bcr-2016-219057.15","doi-asserted-by":"publisher","DOI":"10.1177\/1066896912464047"},{"key":"2025042705580958000_2017.apr26_1.bcr-2016-219057.16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/326053","article-title":"A case of hemophagocytic lymphohistiocytosis in a patient with chronic lymphocytic leukemia after treatment with fludarabine, cyclophosphamide, and rituximab chemotherapy, with autopsy findings","volume":"2012","author":"Tiong","year":"2012","journal-title":"Case Rep Hematol"},{"key":"2025042705580958000_2017.apr26_1.bcr-2016-219057.17","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.35.6139"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2016-219057","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T12:58:18Z","timestamp":1745758698000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2016-219057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,26]]},"references-count":17,"alternative-id":["10.1136\/bcr-2016-219057"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2016-219057","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2017,4,26]]}}}