{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T23:45:00Z","timestamp":1748389500018,"version":"3.40.4"},"reference-count":8,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2017,5,5]]},"abstract":"<jats:p>Twenty-eight-week-old preterm monochorionic\u2013diamniotic twins were admitted to the neonatal intensive care unit secondary to low birth weight and mild respiratory distress syndrome. A low fibrinogen level of less than 0.5\u2009g\/L was detected following an abnormal full blood count. They required fibrinogen transfusions until 32 weeks corrected gestation to maintain adequate fibrinogen levels. Parental screening revealed that their mother had a previously undiagnosed hypofibrinogenaemia. Of note, her only symptom was menorrhagia. This may have implications on further pregnancies as it can be associated with spontaneous miscarriage and post-partum haemorrhage. Congenital hypofibrinogenaemia is a rare disorder and there are no reported cases from Ireland. A higher degree of suspicion for screening is required to detect new cases and demonstrates the benefits of checking parental levels in such situations.<\/jats:p>","DOI":"10.1136\/bcr-2017-219332","type":"journal-article","created":{"date-parts":[[2017,6,5]],"date-time":"2017-06-05T13:25:16Z","timestamp":1496669116000},"page":"bcr-2017-219332","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Congenital hypofibrinogenaemia: a presymptomatic detection of an extremely rare bleeding disorder in preterm twins"],"prefix":"10.1136","volume":"2017","author":[{"given":"Catherine Mary","family":"Breen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad I","family":"Riazat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomi","family":"McCallion","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A","family":"Boyle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2017,6,5]]},"reference":[{"key":"2025042706221900000_2017.jun05_2.bcr-2017-219332.1","first-page":"240","article-title":". U\u00c8 ber faserstoffmangel im Blut bei Einem Falle Von Haemophilie","volume":"132","author":"Rabe","year":"1920","journal-title":"Deutsches Archives Klinische Medizin"},{"key":"2025042706221900000_2017.jun05_2.bcr-2017-219332.2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1349222"},{"key":"2025042706221900000_2017.jun05_2.bcr-2017-219332.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2008.06.004"},{"key":"2025042706221900000_2017.jun05_2.bcr-2017-219332.4","first-page":"1978","article-title":"Congenital disorder of fibrinogen","volume":"27","author":"Agarwal","year":"1981","journal-title":"Journal of Postgraduate Medicine"},{"key":"2025042706221900000_2017.jun05_2.bcr-2017-219332.5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01831.x"},{"key":"2025042706221900000_2017.jun05_2.bcr-2017-219332.6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04424.x"},{"key":"2025042706221900000_2017.jun05_2.bcr-2017-219332.7","doi-asserted-by":"crossref","unstructured":"Ahmed S , Harrity C , Johnson S , et al . The efficacy of fibrinogen concentrate compared with cryoprecipitate in major obstetric haemorrhage-an observational study Transfusion Medicine. 2012;22:344\u20139.doi:10.1111\/j.1365-3148.2012.01178.x","DOI":"10.1111\/j.1365-3148.2012.01178.x"},{"key":"2025042706221900000_2017.jun05_2.bcr-2017-219332.8","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aen270"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2017-219332","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T13:22:28Z","timestamp":1745760148000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2017-219332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,5]]},"references-count":8,"alternative-id":["10.1136\/bcr-2017-219332"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2017-219332","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2017,6,5]]}}}