{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T17:56:07Z","timestamp":1789062967144,"version":"build-2803163510"},"reference-count":15,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2017,5,4]]},"abstract":"<jats:p>Symptomatic hypocalcaemia is an uncommon finding in patients with malignant tumours. We describe a patient with advanced metastatic breast cancer who developed severe hypocalcaemia caused by the combination of osteoblastic metastases and a permanent postoperative hypoparathyroidism. The patient failed to be treated with the conventional replacement therapy and was submitted effectively to radionucleotide therapy with<jats:sup>153<\/jats:sup>Sm.<\/jats:p>","DOI":"10.1136\/bcr-2017-219354","type":"journal-article","created":{"date-parts":[[2017,5,16]],"date-time":"2017-05-16T12:35:24Z","timestamp":1494938124000},"page":"bcr-2017-219354","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Treatment of severe hypocalcaemia due to osteoblastic metastases in a patient with post-thyroidectomy hypoparathyroidism with<sup>153<\/sup>Sm-EDTMP"],"prefix":"10.1136","volume":"2017","author":[{"given":"Eva","family":"Kassi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ifigeneia","family":"Kapsali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michalis","family":"Kokkinos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Gogas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2017,5,16]]},"reference":[{"key":"2025042706113139000_2017.may15_1.bcr-2017-219354.1","first-page":"425","article-title":"Bone turnover markers in serum and urine as diagnostic, prognostic and monitoring biomarkers of bone metastasis","volume":"1846","author":"Jung","year":"2014","journal-title":"Biochim Biophys Acta"},{"key":"2025042706113139000_2017.may15_1.bcr-2017-219354.2","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.0954-6820.1986.tb02745.x","article-title":"A hospital survey of hypocalcemia in patients with malignant disease","volume":"220","author":"Blomqvist","year":"1986","journal-title":"Acta Med Scand"},{"key":"2025042706113139000_2017.may15_1.bcr-2017-219354.3","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1089\/jpm.2013.0389","article-title":"Hungry bone syndrome: persistent hypocalcemia related to osteoblastic bone metastases of prostate cancer","volume":"16","author":"Riveros","year":"2013","journal-title":"J Palliat Med"},{"key":"2025042706113139000_2017.may15_1.bcr-2017-219354.4","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70302-X"},{"key":"2025042706113139000_2017.may15_1.bcr-2017-219354.5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.1989.tb01423.x"},{"key":"2025042706113139000_2017.may15_1.bcr-2017-219354.6","first-page":"255","article-title":"Case report: clinical hypocalcemia: the endocrine conference of the Alton Ochsner Medical Institutions and Tulane University Medical Center","volume":"308","author":"Wiegand","year":"1994","journal-title":"Am J Med Sci"},{"key":"2025042706113139000_2017.may15_1.bcr-2017-219354.7","unstructured":"Bergkamp F , Van Berkel A , van der Linden P , et al . Unexpected prolonged extreme hypocalcaemia and an inadequate PTH response in a patient with metastatic breast carcinoma. 2003;61:371\u20135."},{"key":"2025042706113139000_2017.may15_1.bcr-2017-219354.8","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.284.6317.700"},{"key":"2025042706113139000_2017.may15_1.bcr-2017-219354.9","doi-asserted-by":"crossref","first-page":"139","DOI":"10.11005\/jbm.2012.19.2.139","article-title":"Bisphosphonate-induced severe hypocalcemia - a case report","volume":"19","author":"Do","year":"2012","journal-title":"J Bone Metab"},{"key":"2025042706113139000_2017.may15_1.bcr-2017-219354.10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067312"},{"key":"2025042706113139000_2017.may15_1.bcr-2017-219354.11","first-page":"w13979","article-title":"Bisphosphonate induced hypocalcaemia - report of six cases and review of the literature","volume":"144","author":"Kreutle","year":"2014","journal-title":"Swiss Med Wkly"},{"key":"2025042706113139000_2017.may15_1.bcr-2017-219354.12","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1248\/bpb.33.721","article-title":"Risk factors contributing to the development of hypocalcemia after zoledronic acid administration in patients with bone metastases of solid tumor","volume":"33","author":"Hanamura","year":"2010","journal-title":"Biol Pharm Bull"},{"key":"2025042706113139000_2017.may15_1.bcr-2017-219354.13","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2008-0227"},{"key":"2025042706113139000_2017.may15_1.bcr-2017-219354.14","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.mehy.2011.12.002","article-title":"Bisphosphonate stimulation of osteoblasts and osteoblastic metastasis as a mechanism of hypocalcaemia","volume":"78","author":"Ho","year":"2012","journal-title":"Med Hypotheses"},{"key":"2025042706113139000_2017.may15_1.bcr-2017-219354.15","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1159\/000337634","article-title":"Radionuclide therapy of bone metastases","volume":"7","author":"Fischer","year":"2012","journal-title":"Breast Care"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2017-219354","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T13:11:39Z","timestamp":1745759499000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2017-219354"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,16]]},"references-count":15,"alternative-id":["10.1136\/bcr-2017-219354"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2017-219354","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,16]]}}}