{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T22:07:21Z","timestamp":1773353241341,"version":"3.50.1"},"reference-count":32,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2017,9,20]]},"abstract":"<jats:p>Localised pigmented villonodular synovitis (PVNS) of the knee is a rare diagnosis, with clinical signs and symptoms mimicking meniscal damage or other common knee injuries.<\/jats:p>\n               <jats:p>We report the case of a 24-year-old female soccer player, seeking treatment after 7\u2009months of persisting knee pain. Additionally, we present an overview of tenosynovial giant cell tumours.<\/jats:p>\n               <jats:p>On examination, the patient was found to have tenderness in the medial joint space of the knee. MRI revealed a heterogeneous formation in the central part of the knee. The formation was completely enucleated arthroscopically, histological analyses confirmed the diagnosis of localised PVNS. The patient was subsequently free of symptoms with no signs of recurrence on MRI and had resumed soccer practice at the 1-year follow-up appointment.<\/jats:p>","DOI":"10.1136\/bcr-2017-219549","type":"journal-article","created":{"date-parts":[[2017,10,4]],"date-time":"2017-10-04T07:25:37Z","timestamp":1507101937000},"page":"bcr-2017-219549","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["A rare case of localised pigmented villonodular synovitis in the knee of a 24-year-old female soccer player: diagnosis, management and summary of tenosynovial giant cell tumours"],"prefix":"10.1136","volume":"2017","author":[{"given":"Casper","family":"Falster","sequence":"first","affiliation":[{"name":"Department of Molecular Endocrinology and Stem Cell Research Unit (KMEB), Odense University Hospital, Odense, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Stockmann Poulsen","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery and Sports Traumatology, Odense University Hospital, Odense, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uffe","family":"Joergensen","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery and Sports Traumatology, Odense University Hospital, Odense, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2017,10,4]]},"reference":[{"key":"2025082703284343000_2017.oct03_1.bcr-2017-219549.1","unstructured":"Fletcher CDM , Bridge JA , Hogendoorn PMF . WHO Classification of Tumours of Soft Tissue and Bone: WHO, 2013."},{"key":"2025082703284343000_2017.oct03_1.bcr-2017-219549.2","doi-asserted-by":"crossref","first-page":"901","DOI":"10.5858\/arpa.2012-0165-CR","article-title":"Tenosynovial giant cell tumor: case report and review","volume":"136","author":"Lucas","year":"2012","journal-title":"Arch Pathol Lab Med"},{"key":"2025082703284343000_2017.oct03_1.bcr-2017-219549.3","first-page":"149","article-title":"Giant cell tumor of tendon sheath: study of 64 cases and review of literature","volume":"34","author":"Di Grazia","year":"2013","journal-title":"G Chir"},{"key":"2025082703284343000_2017.oct03_1.bcr-2017-219549.4","first-page":"731","article-title":"Pigmented villonodular synovitis, bursitis and tenosynovitis","volume":"31","author":"Jaffe","year":"1941","journal-title":"Arch Pathol"},{"key":"2025082703284343000_2017.oct03_1.bcr-2017-219549.5","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S1726-4901(10)70022-8","article-title":"Giant Cell Tumor of the Tendon Sheath in the Knee of an 11-year-old Girl","volume":"73","author":"Abdullah","year":"2010","journal-title":"J Chin Med Assoc"},{"key":"2025082703284343000_2017.oct03_1.bcr-2017-219549.6","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.jcot.2014.12.005","article-title":"A rare case of giant cell tumour arising from anterior cruciate ligament: Its diagnosis and management","volume":"6","author":"Agarwala","year":"2015","journal-title":"J Clin Orthop Trauma"},{"key":"2025082703284343000_2017.oct03_1.bcr-2017-219549.7","doi-asserted-by":"crossref","first-page":"718","DOI":"10.3892\/ol.2012.555","article-title":"Giant cell tumor of the tendon sheath: A rare case in the left knee of a 15-year-old boy","volume":"3","author":"Sun","year":"2012","journal-title":"Oncol Lett"},{"key":"2025082703284343000_2017.oct03_1.bcr-2017-219549.8","doi-asserted-by":"publisher","DOI":"10.1053\/jhsu.1999.1298"},{"key":"2025082703284343000_2017.oct03_1.bcr-2017-219549.9","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(92)90340-9"},{"key":"2025082703284343000_2017.oct03_1.bcr-2017-219549.10","doi-asserted-by":"crossref","first-page":"20150528","DOI":"10.1259\/bjr.20150528","article-title":"MRI and thallium features of pigmented villonodular synovitis and giant cell tumours of tendon sheaths: a retrospective single centre study of imaging and literature review","volume":"88","author":"Lynskey","year":"2015","journal-title":"Br J Radiol"},{"key":"2025082703284343000_2017.oct03_1.bcr-2017-219549.11","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.82B4.10328"},{"key":"2025082703284343000_2017.oct03_1.bcr-2017-219549.12","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.otsr.2013.09.017","article-title":"Localized form of pigmented villonodular synovitis of the knee: the meniscal mime","volume":"100","author":"Bouguennec","year":"2014","journal-title":"Orthop Traumatol Surg Res"},{"key":"2025082703284343000_2017.oct03_1.bcr-2017-219549.13","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1007\/s00167-011-1747-y","article-title":"Arthroscopic treatment of localized pigmented villonodular synovitis of the knee","volume":"20","author":"Loriaut","year":"2012","journal-title":"Surg Sport Traumatol Arthrosc"},{"key":"2025082703284343000_2017.oct03_1.bcr-2017-219549.14","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198005000-00004"},{"key":"2025082703284343000_2017.oct03_1.bcr-2017-219549.15","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1080050"},{"key":"2025082703284343000_2017.oct03_1.bcr-2017-219549.16","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.arthro.2007.03.012","article-title":"Long-term follow-up of saurgically treated localized pigmented villonodular synovitis of the knee","volume":"23","author":"Dines","year":"2007","journal-title":"Arthrosc J\u00a0\u00a0of Arthrosc Relat Surg"},{"key":"2025082703284343000_2017.oct03_1.bcr-2017-219549.17","doi-asserted-by":"crossref","first-page":"13","DOI":"10.4103\/2156-7514.152343","article-title":"Malignant tenosynovial giant cell tumor of the leg: a radiologic-pathologic correlation and review of the literature","volume":"5","author":"Richman","year":"2015","journal-title":"J Clin Imaging Sci"},{"key":"2025082703284343000_2017.oct03_1.bcr-2017-219549.18","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1097\/00003086-198910000-00034","article-title":"Pigmented villonodular synovitis. A retrospective review of affected large joints","volume":"247","author":"Schwartz","year":"1989","journal-title":"Clin Orthop Relat Res"},{"key":"2025082703284343000_2017.oct03_1.bcr-2017-219549.19","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1055\/s-0030-1247756","article-title":"Pigmented villonodular synovitis of the knee: diagnosis and treatment","volume":"22","author":"Kramer","year":"2009","journal-title":"J Knee Surg"},{"key":"2025082703284343000_2017.oct03_1.bcr-2017-219549.20","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1016\/S0033-8389(22)00831-4","article-title":"Pigmented villonodular synovitis. Diagnosis and differential diagnosis","volume":"26","author":"Goldman","year":"1988","journal-title":"Radiol Clin North Am"},{"key":"2025082703284343000_2017.oct03_1.bcr-2017-219549.21","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.2106\/00004623-200212000-00011","article-title":"Treatment of advanced primary and recurrent diffuse pigmented villonodular synovitis of the knee","volume":"84","author":"Chin","year":"2002","journal-title":"J Bone Joint Surg Am"},{"key":"2025082703284343000_2017.oct03_1.bcr-2017-219549.22","doi-asserted-by":"crossref","first-page":"119","DOI":"10.2106\/00004623-199274010-00015","article-title":"Pigmented villonodular synovitis of the knee. The results of total arthroscopic synovectomy, partial, arthroscopic synovectomy, and arthroscopic local excision","volume":"74","author":"Ogilvie-Harris","year":"1992","journal-title":"J\u00a0Bone Jt Surg"},{"key":"2025082703284343000_2017.oct03_1.bcr-2017-219549.23","doi-asserted-by":"publisher","DOI":"10.1053\/jars.2001.24068"},{"key":"2025082703284343000_2017.oct03_1.bcr-2017-219549.24","unstructured":"Enzinger FM WS . Benign tumors and tumor-like lesions of synovial tissue. Mosby C , ed. Soft tissue tumors. 3rd edn. St Louis: MO, 1995:735\u201355."},{"key":"2025082703284343000_2017.oct03_1.bcr-2017-219549.25","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200004000-00002"},{"key":"2025082703284343000_2017.oct03_1.bcr-2017-219549.26","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.3892\/ol.2015.3288","article-title":"Diffuse-type giant cell tumor of the tendon sheath in the temporal region incidentally diagnosed due to a temporal tumor: A report of two cases and review of the literature","volume":"10","author":"Qin","year":"2015","journal-title":"Oncol Lett"},{"key":"2025082703284343000_2017.oct03_1.bcr-2017-219549.27","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ejca.2016.04.022","article-title":"Diffuse-type tenosynovial giant cell tumour: Current treatment concepts and future perspectives","volume":"63","author":"Staals","year":"2016","journal-title":"Eur J Cancer"},{"key":"2025082703284343000_2017.oct03_1.bcr-2017-219549.28","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.5858\/2000-124-1636-MGCTOS","article-title":"Malignant giant cell tumor of synovium (malignant pigmented villonodular synovitis)","volume":"124","author":"Layfield","year":"2000","journal-title":"Arch Pathol Lab Med"},{"key":"2025082703284343000_2017.oct03_1.bcr-2017-219549.29","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0507321103"},{"key":"2025082703284343000_2017.oct03_1.bcr-2017-219549.30","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdn033"},{"key":"2025082703284343000_2017.oct03_1.bcr-2017-219549.31","first-page":"134","article-title":"Pigmented villonodular synovitis responsive to imatinib therapy Baylor Sammons Cancer Center at Dallas Site Tumor Conference. ProcBayl Univ Med Cent) Pathol Radiol Oncol (Mennel)","volume":"24","author":"Snoots","year":"2011","journal-title":"Radiat Oncol"},{"key":"2025082703284343000_2017.oct03_1.bcr-2017-219549.32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2010\/174528","article-title":"Therapeutic antibodies targeting CSF1 impede macrophage recruitment in a xenograft model of tenosynovial giant cell tumor","volume":"2010","author":"Cheng","year":"2010","journal-title":"Sarcoma"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2017-219549","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T10:28:55Z","timestamp":1756290535000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2017-219549"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,4]]},"references-count":32,"alternative-id":["10.1136\/bcr-2017-219549"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2017-219549","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,4]]}}}