{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T12:55:06Z","timestamp":1756385706792,"version":"3.44.0"},"reference-count":9,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2018,11,14]]},"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:p>M\u00f6bius syndrome is a neurological disorder involving underdevelopment of the sixth and seventh cranial nerves. Multiple associations have been described including dysfunction of other cranial nerves, limb abnormalities and hypogonadotrophic hypogonadism causing delayed puberty. We present the second reported case of M\u00f6bius syndrome associated with obesity and with precocious puberty. These features may be secondary to dysregulation of the hypothalamic\u2013pituitary axis. We highlight the need to consider extraocular symptoms in these patients and for close liaison with physicians in their management.<\/jats:p>","DOI":"10.1136\/bcr-2017-219590","type":"journal-article","created":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T17:19:47Z","timestamp":1545153587000},"page":"e219590","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["M\u00f6bius syndrome associated with obesity and precocious puberty"],"prefix":"10.1136","volume":"11","author":[{"given":"Samantha Roshani","family":"De Silva","sequence":"first","affiliation":[{"name":"Oxford Eye Hospital, John Radcliffe Hospital, Oxford, Oxfordshire, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sally L","family":"Painter","sequence":"additional","affiliation":[{"name":"Oxford Eye Hospital, John Radcliffe Hospital, Oxford, Oxfordshire, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darius","family":"Hildebrand","sequence":"additional","affiliation":[{"name":"Oxford Eye Hospital, John Radcliffe Hospital, Oxford, Oxfordshire, UK"},{"name":"Eye Unit, Royal Berkshire NHS, Reading, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,12,7]]},"reference":[{"key":"2025082707212166000_11.1.e219590.1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320370432"},{"key":"2025082707212166000_11.1.e219590.2","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/ajmg.a.20500","article-title":"Moebius sequence and hypogonadotrophic hypogonadism","volume":"123A","author":"Jennings","year":"2003","journal-title":"Am J Med Genet A"},{"key":"2025082707212166000_11.1.e219590.3","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1975.00490490084010"},{"key":"2025082707212166000_11.1.e219590.4","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/5.9.1367"},{"key":"2025082707212166000_11.1.e219590.5","doi-asserted-by":"crossref","first-page":"156","DOI":"10.3928\/0191-3913-20010501-09","article-title":"Ocular and clinical manifestations of M\u00f6bius' syndrome","volume":"38","author":"Cronemberger","year":"2001","journal-title":"J Pediatr Ophthalmol Strabismus"},{"key":"2025082707212166000_11.1.e219590.6","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/j.1399-0004.1995.tb03938.x","article-title":"Premature thelarche in M\u00f6bius syndrome","volume":"47","author":"Ichiyama","year":"1995","journal-title":"Clin Genet"},{"key":"2025082707212166000_11.1.e219590.7","first-page":"776","article-title":"[Moebius syndrome associated with obesity, dwarfism, endocrinological abnormalities and various minor anomalies]","volume":"75","author":"Utoh","year":"1986","journal-title":"Nihon Naika Gakkai Zasshi"},{"key":"2025082707212166000_11.1.e219590.8","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8199"},{"key":"2025082707212166000_11.1.e219590.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2003.12.005"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bcr-2017-219590","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2017-219590","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T14:21:28Z","timestamp":1756304488000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2017-219590"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":9,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,12,7]]},"published-print":{"date-parts":[[2018,11]]}},"alternative-id":["10.1136\/bcr-2017-219590"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2017-219590","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2018,11]]}}}