{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:23:15Z","timestamp":1788304995816,"version":"build-2803163510"},"reference-count":10,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Reports"],"accepted":{"date-parts":[[2017,5,15]]},"abstract":"<jats:p>A 57-year-old woman with frequent respiratory infections was initially diagnosed with IgG subclass deficiency based on low levels of IgG subclasses 2 and 3. Three years later, she progressed to having IgA deficiency as well. With a normal total IgG level, she does not meet criteria for common variable immunodeficiency (CVID). This may represent a variant of CVID. This also highlights the importance of immunoglobulin subclass estimation in patients where immunodeficiency is suspected clinically. She is being treated with rotational antibiotics the first 10 days of every month, monthly intravenous immunoglobulin (IVIG) infusion and osteopathic manipulation one to two times per month. On this regimen, although she has had several viral respiratory infections, she has avoided further hospitalisation for more than 1\u2009year.<\/jats:p>","DOI":"10.1136\/bcr-2017-219655","type":"journal-article","created":{"date-parts":[[2017,5,27]],"date-time":"2017-05-27T11:45:18Z","timestamp":1495885518000},"page":"bcr-2017-219655","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Novel variant of common variable immunodeficiency"],"prefix":"10.1136","volume":"2017","author":[{"given":"Eileen","family":"Conaway","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2017,5,27]]},"reference":[{"key":"2025042706171495000_2017.may27_1.bcr-2017-219655.1","doi-asserted-by":"publisher","DOI":"10.1080\/00365540600951192"},{"key":"2025042706171495000_2017.may27_1.bcr-2017-219655.2","unstructured":"Selective IgA Deficiency. Primary Immune Deficiency Foundation. http:\/\/primaryimmune.org\/about-primary-immunodeficiencies\/specific-disease-types\/selective-iga-deficiency\/ (Accessed August 6, 2016)."},{"key":"2025042706171495000_2017.may27_1.bcr-2017-219655.3","unstructured":"Wiskott-Aldrich syndrome. NIH Genetics Home Reference. https:\/\/ghr.nlm.nih.gov\/condition\/wiskott-aldrich-syndrome#statistics (Accessed April 17, 2017)."},{"key":"2025042706171495000_2017.may27_1.bcr-2017-219655.4","unstructured":"Agammaglobulinemia. Primary Immune Deficiency Foundation. http:\/\/primaryimmune.org\/about-primary-immunodeficiencies\/specific-disease-types\/agammaglobulinemia-x-linked-autosomal-recessive\/ (Accessed April 17, 2017)."},{"key":"2025042706171495000_2017.may27_1.bcr-2017-219655.5","unstructured":"Haynes BF , Soderberg KA , Fauci AS . \u201cIntroduction to the Immune System\u201d. Harrison\u2019s Principles of Internal Medicine. 19th Edition. New York, NY: BMJ Publishing Group, 2014. http:\/\/accessmedicine.mhmedical.com.ezproxylocal.library.nova.edu\/content.aspx?bookid=1130&sectionid=79749406."},{"key":"2025042706171495000_2017.may27_1.bcr-2017-219655.6","unstructured":"IgG Subclass Deficiency. Primary Immune Deficiency Foundation. http:\/\/primaryimmune.org\/about-primary-immunodeficiencies\/specific-disease-types\/igg-subclass-deficiency\/ (Accessed April 18, 2017)."},{"key":"2025042706171495000_2017.may27_1.bcr-2017-219655.7","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00415"},{"key":"2025042706171495000_2017.may27_1.bcr-2017-219655.8","doi-asserted-by":"publisher","DOI":"10.1006\/clim.1999.4725"},{"key":"2025042706171495000_2017.may27_1.bcr-2017-219655.9","first-page":"406","article-title":"More about the use of OMT during influenza epidemics","volume":"104","author":"Magoun","year":"2004","journal-title":"J Am Osteopath Assoc"},{"key":"2025042706171495000_2017.may27_1.bcr-2017-219655.10","doi-asserted-by":"publisher","DOI":"10.1186\/1750-4732-4-2"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2017-219655","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T13:17:22Z","timestamp":1745759842000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2017-219655"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,27]]},"references-count":10,"alternative-id":["10.1136\/bcr-2017-219655"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2017-219655","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,27]]}}}